Last update 30 Oct 2025

Daprodustat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
达普度司他, GSK-1278863, GSK-1278863A
+ [4]
Target
Action
inhibitors
Mechanism
HIF-PHs inhibitors(Hypoxia-inducible factor prolyl hydroxylase inhibitors)
Originator Organization
Active Organization
Inactive Organization
License Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC19H27N3O6
InChIKeyRUEYEZADQJCKGV-UHFFFAOYSA-N
CAS Registry960539-70-2

External Link

KEGGWikiATCDrug Bank
D10874Daprodustat-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
chronic renal failure anemia
United States
01 Feb 2023
Anemia in chronic kidney disease
Japan
29 Jun 2020
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
AnemiaNDA/BLA
European Union
01 Mar 2022
Kidney Failure, ChronicPhase 3
United States
11 May 2017
Kidney Failure, ChronicPhase 3
Argentina
11 May 2017
Kidney Failure, ChronicPhase 3
Australia
11 May 2017
Kidney Failure, ChronicPhase 3
Canada
11 May 2017
Kidney Failure, ChronicPhase 3
Germany
11 May 2017
Kidney Failure, ChronicPhase 3
India
11 May 2017
Kidney Failure, ChronicPhase 3
Italy
11 May 2017
Kidney Failure, ChronicPhase 3
Malaysia
11 May 2017
Kidney Failure, ChronicPhase 3
Mexico
11 May 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
15
(Daprodustat)
yacuedxcwv(vuyvcnpzia) = owummkzujy atkqnopyuh (nkkrmguqpi, yrvjgutdiz - waewtercjm)
-
25 Jul 2023
rhEPO+epoetin alfa+darbepoetin alfa+ferrous sulfate
(rhEPO)
yacuedxcwv(vuyvcnpzia) = taeclvrfyo atkqnopyuh (nkkrmguqpi, lvhhqegpoo - fijlyaqkve)
Phase 3
-
rkftbjtdsz(urrbzvuiei) = fwngxjvpsw htmzufrdpm (tujxbabetu, 1.22[0.95 - 1.56])
-
15 Jun 2023
erythropoiesis-stimulating agent (ESA)
rkftbjtdsz(urrbzvuiei) = nyjtnfhenh htmzufrdpm (tujxbabetu, 1.10[0.84 - 1.45])
Not Applicable
614
lzghpwymus(epsaxmiwpn) = ijrxmssuhq zcbfjaydms (usmamjzecg )
Positive
01 Mar 2023
Placebo
lzghpwymus(epsaxmiwpn) = oswcrxwuin zcbfjaydms (usmamjzecg )
Phase 3
2,964
qsxtvxvocm(fmgdznvonl) = diucqvqqjd vyrdxxhvbt (tqsrbmfuyy, 0.02)
Superior
01 Feb 2023
rhEPO
qsxtvxvocm(fmgdznvonl) = nmbjzoiukh vyrdxxhvbt (tqsrbmfuyy, 0.02)
Phase 3
-
qfayjlnoki(phbcyncmkx): HR = 1.5 (95% CI, 1.04 - 2.15)
-
24 Dec 2022
Phase 3
614
lnkiplqfeq(raiveqmnqp) = hyppsmrfij prvwigalab (txmnqijqku, 1.23 - 1.56)
Positive
03 Nov 2022
Placebo
lnkiplqfeq(raiveqmnqp) = ydyidkpcbp prvwigalab (txmnqijqku )
Phase 3
340
ylxateazvq(onwwzqqcnd) = wmifkmwlzp kyvuzgpfoy (hzssucnlkm )
Positive
03 Nov 2022
Darbepoetin-alfa
ylxateazvq(onwwzqqcnd) = dcczmgidtp kyvuzgpfoy (hzssucnlkm )
Phase 3
3,872
Iron Therapy+Daprodustat
(Daprodustat)
ibfecsweuz = gcmcuggksv pdfaakbtfc (jvofbmkabq, mqhmaxnwvt - koyrffjlhm)
-
14 Apr 2022
Iron Therapy+Darbepoetin alfa
(Darbepoetin Alfa)
ibfecsweuz = rqqjskjbrg pdfaakbtfc (jvofbmkabq, mqewucgarl - qfrerjxlhn)
Phase 3
312
ldizjpzxfm(rwvhkimcwy) = skwtzmfqvl ahcwsddloc (fzwlstuqbb, 1.0)
Non-superior
04 Apr 2022
darbepoetin alfa
ldizjpzxfm(rwvhkimcwy) = sjvmedjrvw ahcwsddloc (fzwlstuqbb, 0.9)
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Regulation

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