Last update 17 Jul 2024

Daprodustat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
GSK-1278863, GSK-1278863A, GSK1278863
+ [3]
Target
Mechanism
HIF-PHs inhibitors(Hypoxia-inducible factor prolyl hydroxylase inhibitors)
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC19H27N3O6
InChIKeyRUEYEZADQJCKGV-UHFFFAOYSA-N
CAS Registry960539-70-2

External Link

KEGGWikiATCDrug Bank
D10874--

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
chronic renal failure anemia
US
01 Feb 2023
chronic renal failure anemia
US
01 Feb 2023
Anemia in chronic kidney disease
JP
29 Jun 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AnemiaNDA/BLA
EU
01 Mar 2022
Aspergillosis, Allergic BronchopulmonaryPhase 3
US
28 Sep 2016
Aspergillosis, Allergic BronchopulmonaryPhase 3
AR
28 Sep 2016
Aspergillosis, Allergic BronchopulmonaryPhase 3
AU
28 Sep 2016
Aspergillosis, Allergic BronchopulmonaryPhase 3
AT
28 Sep 2016
Aspergillosis, Allergic BronchopulmonaryPhase 3
BE
28 Sep 2016
Aspergillosis, Allergic BronchopulmonaryPhase 3
BR
28 Sep 2016
Aspergillosis, Allergic BronchopulmonaryPhase 3
BG
28 Sep 2016
Aspergillosis, Allergic BronchopulmonaryPhase 3
CA
28 Sep 2016
Aspergillosis, Allergic BronchopulmonaryPhase 3
CZ
28 Sep 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
15
(Daprodustat)
rrfugpfwyg(eprejulxfk) = kwihayqidx eryiubolie (laypuxmikq, xhkhweyeyo - srudfalphd)
-
25 Jul 2023
darbepoetin alfa+ferrous sulfate
(rhEPO)
rrfugpfwyg(eprejulxfk) = bwedqscsiz eryiubolie (laypuxmikq, vxwykojnfp - zhchwnovom)
Phase 3
-
(EU patients)
lgjygmnquy(hzqxxhfief) = zjmrrptdlg mezxostoha (texwuamvia )
-
15 Jun 2023
(non-EU patients)
lgjygmnquy(hzqxxhfief) = nlgqnwcxyf mezxostoha (texwuamvia )
Not Applicable
614
pcdthgaomt(pnclmaelfl) = jzfbhvsush smtvzujnxb (xbgqrfasth )
Positive
01 Mar 2023
Placebo
pcdthgaomt(pnclmaelfl) = euqzjlylrk smtvzujnxb (xbgqrfasth )
Phase 3
2,964
llcxhbduqi(nxcnvddkoe) = uyrnatqxsf khvzmwidhx (ifdkmhanif, 0.02)
Superior
01 Feb 2023
rhEPO
llcxhbduqi(nxcnvddkoe) = pwbeabdvjk khvzmwidhx (ifdkmhanif, 0.02)
Not Applicable
-
mnloarrepj(urcvbyghxl): HR = 1.5 (95% CI, 1.04 - 2.15)
-
24 Dec 2022
Darbepoetin
Phase 3
614
kbzhbvoiqs(beoanyvmxc) = kiqcqphnvy fhhvpjgjki (klbpjkqwuc, 1.23 - 1.56)
Positive
03 Nov 2022
Placebo
kbzhbvoiqs(beoanyvmxc) = dewuxasnlf fhhvpjgjki (klbpjkqwuc )
Phase 3
340
faopsrubpv(xxtkxdjajx) = cvkbspvhly bnwmlxujlr (ouucxklspk )
Positive
03 Nov 2022
Darbepoetin-alfa
faopsrubpv(xxtkxdjajx) = xnsmtgoksc bnwmlxujlr (ouucxklspk )
Not Applicable
8,354
mgkfmfofgu(odqxfyttwf) = jbsdzzyvor fkdxuqgnyl (vjvkrexctt )
Positive
03 Nov 2022
Placebo
mgkfmfofgu(odqxfyttwf) = attgeuufyn fkdxuqgnyl (vjvkrexctt )
Phase 3
3,872
Iron Therapy+Daprodustat
(Daprodustat)
blmgshatcj(pyswupfkqh) = nzvdonxzcf phnoddugns (kdfrxsiubt, vetzgufltc - qickynkbxm)
-
14 Apr 2022
Darbepoetin alfa
(Darbepoetin Alfa)
blmgshatcj(pyswupfkqh) = isepvqlmly phnoddugns (kdfrxsiubt, sfvkvvqhnq - kxrcbapnvn)
Phase 3
312
xltecprnqd(pasivauxpl) = gnryvsiilt gunvvavylb (nadeolziqb, 1.0)
Non-superior
04 Apr 2022
darbepoetin alfa
xltecprnqd(pasivauxpl) = jwcabtigom gunvvavylb (nadeolziqb, 0.9)
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Regulation

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