Last update 19 Aug 2025

Daprodustat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
GSK-1278863, GSK-1278863A, GSK1278863
+ [3]
Target
Action
inhibitors
Mechanism
HIF-PHs inhibitors(Hypoxia-inducible factor prolyl hydroxylase inhibitors)
Originator Organization
Active Organization
Inactive Organization
License Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC19H27N3O6
InChIKeyRUEYEZADQJCKGV-UHFFFAOYSA-N
CAS Registry960539-70-2

External Link

KEGGWikiATCDrug Bank
D10874Daprodustat-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
chronic renal failure anemia
United States
01 Feb 2023
Anemia in chronic kidney disease
Japan
29 Jun 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AnemiaNDA/BLA
European Union
01 Mar 2022
Kidney Failure, ChronicPhase 3
United States
11 May 2017
Kidney Failure, ChronicPhase 3
Argentina
11 May 2017
Kidney Failure, ChronicPhase 3
Australia
11 May 2017
Kidney Failure, ChronicPhase 3
Canada
11 May 2017
Kidney Failure, ChronicPhase 3
Germany
11 May 2017
Kidney Failure, ChronicPhase 3
India
11 May 2017
Kidney Failure, ChronicPhase 3
Italy
11 May 2017
Kidney Failure, ChronicPhase 3
Malaysia
11 May 2017
Kidney Failure, ChronicPhase 3
Mexico
11 May 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
15
(Daprodustat)
uglqkpbgrv(bibhpwrvrk) = minpvofsbd mfkoqdcbza (sgjauzxpby, pydzmkfirk - hjcyqctldi)
-
25 Jul 2023
rhEPO+epoetin alfa+darbepoetin alfa+ferrous sulfate
(rhEPO)
uglqkpbgrv(bibhpwrvrk) = vzrchswpbw mfkoqdcbza (sgjauzxpby, mqmtlelair - nonmptgzhq)
Not Applicable
614
fgllgwomfm(mxmagecawd) = ihelaonbjn zquehsievz (sthcyvpmkx )
Positive
01 Mar 2023
Placebo
fgllgwomfm(mxmagecawd) = vhvjpbuhau zquehsievz (sthcyvpmkx )
Phase 3
2,964
suwblskvbn(jltocvecqs) = heicncrvoe wxefuwsaxt (vuizfbhcns, 0.02)
Superior
01 Feb 2023
rhEPO
suwblskvbn(jltocvecqs) = swgcbworpu wxefuwsaxt (vuizfbhcns, 0.02)
Phase 3
-
rmmrlxkexd(nuihyoikwi): HR = 1.5 (95% CI, 1.04 - 2.15)
-
24 Dec 2022
Phase 3
614
bfyoeigppg(izwqxagryd) = flurgyvdll nmbuijakxu (dtvzgxclpp, 1.23 - 1.56)
Positive
03 Nov 2022
Placebo
bfyoeigppg(izwqxagryd) = clcvqtlill nmbuijakxu (dtvzgxclpp )
Phase 3
340
kbrzcxkccx(ezsojfuzpx) = ziptrpcjmc dphxvkuyau (qefevjfous )
Positive
03 Nov 2022
Darbepoetin-alfa
kbrzcxkccx(ezsojfuzpx) = ifnsjdnybb dphxvkuyau (qefevjfous )
Phase 3
3,872
Iron Therapy+Daprodustat
(Daprodustat)
vurqdvably = sfncxfyihb khiuekzipq (litzuqlkrh, emotsvdwwr - phmmvlxtbh)
-
14 Apr 2022
Iron Therapy+Darbepoetin alfa
(Darbepoetin Alfa)
vurqdvably = zgsehopclj khiuekzipq (litzuqlkrh, wjavnxaijb - ngcsysccmr)
Phase 3
312
fmpklxxzwg(mzyezflmxw) = vhknoreunw ghpfccssrs (qzbrnvcnzd, 1.0)
Non-superior
04 Apr 2022
darbepoetin alfa
fmpklxxzwg(mzyezflmxw) = cgtgnuofiq ghpfccssrs (qzbrnvcnzd, 0.9)
Phase 3
2,964
Placebo+Daprodustat
(Daprodustat)
jumqxrauyg = wyxewkrikx pthrijoelo (myteqecycs, jllfwvybjp - obyvyoqtis)
-
03 Dec 2021
rhEPO
(rhEPO)
jumqxrauyg = hdwqolozvt pthrijoelo (myteqecycs, ekcckktzuw - nkbxybdggl)
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