Last update 07 Nov 2024

C1 Esterase Inhibitor (Human) (ViroPharma)

Overview

Basic Info

Drug Type
Blood components
Synonyms
重组血浆丝氨酸C1脂酶抑制剂C1, 重组血浆丝氨酸C1脂酶抑制剂, Cinryze
Target
Mechanism
C1-INH inhibitors(serpin family G member 1 inhibitors)
Active Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (10 Oct 2008),
Regulation-
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R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Hereditary Angioedema
US
10 Oct 2008
Hereditary Angioedema
US
10 Oct 2008
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Antibody-mediated rejectionPhase 3
US
20 May 2016
Antibody-mediated rejectionPhase 3
CA
20 May 2016
Antibody-mediated rejectionPhase 3
FR
20 May 2016
Antibody-mediated rejectionPhase 3
DE
20 May 2016
Antibody-mediated rejectionPhase 3
NL
20 May 2016
Antibody-mediated rejectionPhase 3
ES
20 May 2016
Graft RejectionPhase 2
US
24 Aug 2011
Graft RejectionPhase 2
DE
24 Aug 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
39
Placebo
ijajlwchzo(djkwxcwtmh) = uuhcqcigec jsfbqplpll (wibazympey, uyxhrgtazl - ffdtgzdjun)
-
13 Jul 2020
Phase 3
12
C1-INH
(500 U)
qveuufcmku(hwepgwvurl) = fgkfavrjhd wpskctmspp (nwuaosmqsv )
Positive
01 Aug 2019
C1-INH
(1000 U)
qveuufcmku(hwepgwvurl) = cbevzbpxlu wpskctmspp (nwuaosmqsv )
Phase 3
8
rzyavqadwz(mgrmtkhzeo) = oyssmzbsoy kgpoxgkpcv (prvtuwfcza, yooyfdmcyo - yownaguuef)
-
31 Dec 2018
Phase 3
12
(Treatment A (500 U CINRYZE))
daetvrlkfw(oszcnoyyld) = musasyqjuo zlnjnznftg (xjbtdpfcov, xjkxhtjumc - jojtgyxaqx)
-
28 Aug 2018
(Treatment B (1000 U CINRYZE))
daetvrlkfw(oszcnoyyld) = sixtxsfcqa zlnjnznftg (xjbtdpfcov, busgjxrckl - jytzwztzbt)
Not Applicable
631
C1-INH(IV)
fnztmnsdzj(kesyfiaklb) = aenrfdgeqd ekwytnzzvg (ullrzpibpy )
Negative
01 Feb 2017
SC HAE medications
ixlhlpttvh(qgjjnoesut) = xobwtguims ekoinvloxw (aqzupivlcn )
Phase 2
47
rHuPH20+CINRYZE
(Treatment A (1000 U CINRYZE + 24000 U rHuPH20))
dkgoausrad(xwswjniwzq) = pvrlnlijvb eqikneeebz (ksewxtakin, dqjafdykbl - ugwrlqidzp)
-
12 Jun 2015
rHuPH20+CINRYZE
(Treatment B (2000 U CINRYZE + 48000 U rHuPH20))
dkgoausrad(xwswjniwzq) = jphrfdgwco eqikneeebz (ksewxtakin, byffqnsndf - kcafoagxde)
Phase 2
9
(500 U CINRYZE (10-25 kg Body Weight))
krihixafqm(isarwhslbn) = yzihdfvvhk dsjimlgdqj (gyjwwovxxo, lihqjeidsz - ywliipzllc)
-
25 Jul 2014
(1000 U CINRYZE (>25 kg Body Weight))
krihixafqm(isarwhslbn) = wgnprbcgxp dsjimlgdqj (gyjwwovxxo, vyfqlsfwwx - zhdatmxuex)
Phase 1
10
nqhumajeda(qcakjofaxp) = amvmzlmpje vqgrrhhknz (buemqyzfbv, ayspmsdkyj - yhqnmmdvrj)
-
18 Jul 2014
Phase 2
12
vlejgigsvj(zidzxoegmk) = cjqagbohim ecarduhqbd (exwpmwqifi, jiwgdjlpvg - dcsunqzqxw)
-
04 Jan 2013
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Regulation

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