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Last update 08 Nov 2025
Mosperafenib
Last update 08 Nov 2025
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms RG-6344, RG6344, RO 7276389 + [1] |
Target |
Action inhibitors |
Mechanism BRAF inhibitors(Serine/threonine-protein kinase B-raf inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhasePhase 1 |
First Approval Date- |
Regulation- |
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Structure/Sequence
Molecular FormulaC20H17F2N5O4S |
InChIKeyZUXPFTYMSHPRQX-GFCCVEGCSA-N |
CAS Registry2649372-20-1 |
R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Solid tumor | Phase 1 | Switzerland | 10 Mar 2025 | |
| BRAF V600 mutation-positive Melanoma | Phase 1 | United States | 01 Jun 2022 | |
| BRAF Mutation colorectal cancers | Preclinical | Switzerland | 29 Apr 2025 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Phase 1 | BRAF V600 mutant Colorectal Cancer BRAF V600 allele frequency (AF) | 51 | qydugvooqx(daxhqatuvx) = CFB at C1D15 showed a significant association with longer PFS (CFB ≥ -75%; HR = 0.27; Pval < 0.01, mPFS 9.2 vs 3.6 months) qxxiakgudv (ghjsdqrbqx ) View more | Positive | 17 Oct 2025 | ||
Phase 1 | BRAF V600E mutant Colorectal Cancer BRAF V600E mutation | 51 | qawiwkbonv(biukubzfsr) = 23.6% nbcsijariv (qlcyzkmmpj ) View more | Positive | 30 May 2025 |
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