Delving into the Latest Updates on Pramiconazole with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Azoline, Pramiconazole (USAN/INN), R 126638

+ [1]

Target

fungal CYP51A1

Action

inhibitors

Mechanism

fungal CYP51A1 inhibitors(Fungal CYP51A1 inhibitors)

Therapeutic Areas

Infectious DiseasesSkin and Musculoskeletal Diseases

Active Indication

OnychomycosisTinea Versicolor

Inactive Indication-

Originator Organization

Johnson & Johnson

Active Organization

GSK Plc

Johnson & Johnson

Inactive Organization-

License Organization-

Drug Highest PhasePhase 2

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC35H39F2N7O4

InChIKeyAEKNYBWUEYNWMJ-QWOOXDRHSA-N

CAS Registry219923-85-0

Abstract: Enhancing photocatalytic selectivity is essential for the effective and efficient utilization of catalysts.In this study, a molecularly imprinted polymer POPD/Bi₂O₃/CeO₂, designated as MIP-POPD/Bi₂O₃/CeO₂, was successfully synthesized via photopolymerization using pyridine as a template.The resulting MIP-POPD/Bi₂O₃/CeO₂ was characterized through Fourier transform IR spectroscopy, SEM, X-ray diffraction, XPS, N₂ adsorption-desorption isotherms, and UV-vis diffuse reflectance spectroscopy.MIP-POPD/Bi₂O₃/CeO₂ exhibited enhanced charge transfer and efficient separation of photogenerated carriers, as confirmed by photoluminescence measurements, electrochem. impedance spectroscopy anal., and photocurrent response (I-t) curve evaluations.When the concentration of pyridine in simulated oil reached 80 μg/g, with an amount of 1.6 g/L for MIP-POPD/Bi₂O₃/CeO₂ and an illumination time of 120 min, the degradation rate of pyridine achieved 80%, which is 1.57 times greater than that observed using NMIP-POPD/Bi₂O₃/CeO₂.After an adsorption for 30 min, MIP-POPD/Bi₂O₃/CeO₂ exhibited the adsorption capacity of 5 mg/g, attributed to the large number of molecularly imprinted pores on its surface.In various mixed systems, the selectivity coefficients for pyridine using MIP-POPD/Bi₂O₃/CeO₂ consistently exceeded 1.5, which can be attributed to the selective adsorption properties of the imprinted pores within the polymers that preferentially recognize and remove pyridine.Furthermore, after five cycles, the photocatalytic degradation rate of pyridine by MIP-POPD/Bi₂O₃/CeO₂ can still reach 77%, indicating that MIP-POPD/Bi₂O₃/CeO₂ possesses good stability.Trapping experiments demonstrated that superoxide radicals (·O₂^-) and holes (h⁺) were the predominant active species in photocatalytic reactions.Addnl., a proposed mechanism for photocatalytic denitrification utilizing MIP-POPD/Bi₂O₃/CeO₂ was presented.This study provides a promising strategy for designing Bi-based mol. imprinting photocatalysts aimed at efficiently removing low-concentration, highly toxic target pollutants from mixed samples.

01 Dec 2022·Bulletin of the National Research Centre

In silico prediction and structure-based multitargeted molecular docking analysis of selected bioactive compounds against mucormycosis

Article

Author: Ramprabhu, Nagarjun ; Madanagopal, Premnath ; Jagadeesan, Rahul

Abstract:

Background:

During the second wave of the COVID-19 pandemic, an unusual increase in cases of mucormycosis was observed in India, owing to immunological dysregulation caused by the SARS-CoV-2 and the use of broad-spectrum antibiotics, particularly in patients with poorly controlled diabetes with ketoacidosis to have contributed to the rise, and it has been declared an epidemic in several states of India. Because of the black colouring of dead and dying tissue caused by the fungus, it was dubbed "black fungus" by several Indian media outlets. In this study, attempts were taken to unmask novel therapeutic options to treat mucormycosis disease. Rhizopus species is the primary fungi responsible for 70% of mucormycosis cases.

Results:

We chose three important proteins from the Rhizopus delemar such as CotH3, Lanosterol 14 alpha-demethylase and Mucoricin which plays a crucial role in the virulence of Mucorales. Initially, we explored the physiochemical, structural and functional insights of proteins and later using AutoDock Vina, we applied computational protein–ligand binding modelling to perform a virtual screening around 300 selected compounds against these three proteins, including FDA-approved drugs, FDA-unapproved drugs, investigational-only drugs and natural bioactive compounds. ADME parameters, toxicity risk and biological activity of those compounds were approximated via in silico methods. Our computational studies identified six ligands as potential inhibitors against Rhizopus delemar, including 12,28-Oxamanzamine A, vialinin B and deoxytopsentin for CotH3; pramiconazole and saperconazole for Lanosterol 14 alpha-demethylase; and Hesperidin for Mucoricin. Interestingly, 12,28-Oxamanzamine A showed a maximum binding affinity with all three proteins (CotH3: − 10.2 kcal/mol Lanosterol 14 alpha-demethylase: − 10.9 kcal/mol Mucoricin: − 8.6 kcal/mol).

Conclusions:

In summary, our investigation identified 12,28-Oxamanzamine A, vialinin B, deoxytopsentin, pramiconazole, saperconazole and hesperidin as potent bioactive compounds for treating mucormycosis that may be considered for further optimisation techniques and in vitro and in vivo studies.

17 Nov 2022·Microbiology resource announcements

Complete Genome Sequences of Two Rhizobium Strains Producing Azol(in)e-Modified Antibiotics

Article

Author: Severinov, Konstantin ; Travin, Dmitrii Y. ; Sutormin, Dmitry ; Mergaert, Peter

Rhizobia are known for their ability to establish symbiotic relationships with plants. The specialized metabolism of these bacteria remains understudied. Here, we report whole-genome sequences of two rhizobia producing narrow-spectrum antirhizobial azol(in)e-modified peptides: that of Rhizobium sp. Pop5, a phazolicin producer, and another of Rhizobium anhuiense T24, a trifolitoxin producer.

100 Deals associated with Pramiconazole

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