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Last update 08 May 2025

Tinea Versicolor

Last update 08 May 2025

Basic Info

Synonyms

Infection by Malassezia furfur, Infection by Pityrosporum furfur, Infection, Malassezia furfur

+ [41]

Introduction

A common chronic, noninflammatory and usually symptomless disorder, characterized by the occurrence of multiple macular patches of all sizes and shapes, and varying in pigmentation from fawn-colored to brown. It is seen most frequently in hot, humid, tropical regions and is mostly caused by MALASSEZIA FURFUR (formerly Pityrosporum orbiculare).

Drugs associated with Tinea Versicolor

Bifonazole

Target

fungal CYP51A1

Mechanism

fungal CYP51A1 inhibitors

Active Org.

Originator Org.

Active Indication

Inactive Indication

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

Japan

First Approval Date08 May 2009

Tolnaftate

Target

Ergosterol

Mechanism

Ergosterol biosynthesis inhibitors

Active Org.

Choseido Pharmaceutical Co., Ltd.

Originator Org.

Choseido Pharmaceutical Co., Ltd.

Active Indication

Psoriasis [+2]

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

Japan

First Approval Date22 Mar 2007

Luliconazole

Target

fungal CYP51A1

Mechanism

fungal CYP51A1 inhibitors

Active Org.

Bausch Health US LLC [+7]

Originator Org.

Nihon Nohyaku Co., Ltd.

Active Indication

Tinea Manus [+9]

Inactive Indication

Candidiasis, Chronic Mucocutaneous

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

Japan

First Approval Date11 Apr 2005

Clinical Trials associated with Tinea Versicolor

NCT06922344

/ RecruitingPhase 4IIT

Comparison of Efficacy of Oral Fluconazole Versus Oral Itraconazole in the Treatment of Pityriasis Versicolor

This study compares the efficacy of two drugs, namely flucanazole and itraconazole for the treatment of a common fungal infection of skin.

Start Date01 Mar 2025

Sponsor / Collaborator

Khyber Teaching Hospital

IRCT20241028063523N4

/ RecruitingPhase 4IIT

Comparative efficacy of combined treatment with ketoconazole 2% cream and adapalene 0.1% gel versus ketoconazole 2% cream monotherapy in pityriasis versicolor.

Start Date19 Nov 2024

Sponsor / Collaborator-

IRCT20241028063523N1

/ RecruitingPhase 4IIT

Comparative efficacy of bifonazole and clotrimazole in the treatment of pitryasis versicolor

Start Date01 Nov 2024

Sponsor / Collaborator-

100 Clinical Results associated with Tinea Versicolor

100 Translational Medicine associated with Tinea Versicolor

0 Patents (Medical) associated with Tinea Versicolor

1,259

Literatures (Medical) associated with Tinea Versicolor

01 May 2025·Dermatology and Therapy

Risk of Superficial Fungal Infections in WHIM Syndrome

Article

Author: Meltzer, Jasmine C ; Castelo-Soccio, Leslie ; Martinez, Sophia ; Adhanom, Rutha ; McDermott, David H ; Brownell, Isaac ; Strong, Jennifer ; Salancy, Abigail ; Murphy, Philip M ; Hallaert, Patrick ; Kong, Heidi H ; Kim, Caleb S ; Cowen, Edward W ; Saito, Yoshine

INTRODUCTIONWHIM syndrome is a rare autosomal dominant inborn error of immunity caused by gain-of-function mutations in the chemokine receptor CXCR4. Patients with WHIM syndrome frequently suffer from an increased risk for bacterial and viral infections, especially warts due to human papillomavirus. Associations between WHIM syndrome and fungal infections have not been previously identified. The objective of this study was to estimate the prevalence of superficial fungal infections in patients with WHIM syndrome.METHODSThis retrospective single-institution cohort study assessed patients with genotype-confirmed WHIM syndrome evaluated between March 2007 and March 2024.RESULTSOf 45 patients with WHIM syndrome, 18 (40%) were diagnosed with at least one superficial fungal infection. These infections included dermatophytosis (n = 14, 78%), pityriasis versicolor (n = 6, 33%), and pityrosporum folliculitis (n = 1, 6%). No correlation was detected between superficial fungal infection risk and the degree of peripheral neutropenia, lymphopenia, or hypogammaglobulinemia. The median time to resolution of the longest episode of superficial dermatophytosis (skin or hair) was 171.5 (range 53-3650) days, and several patients experienced prolonged courses requiring serial retreatments.CONCLUSIONSThese findings suggest that frequent or prolonged superficial fungal infections may be a useful clinical sign to prompt consideration of a WHIM syndrome diagnosis, especially in patients with numerous cutaneous warts or other history to suggest immunodeficiency.TRIAL REGISTRATIONParticipants were enrolled in a natural history trial registered with ClinicalTrials.gov (NCT00128973).

01 May 2025·Diagnostic Microbiology and Infectious Disease

PCR sequencing and re-evaluation of pathologic findings revealed invasive fungal sinusitis caused by Malassezia restricta

Article

Author: Kim, Da Young ; Lim, Sung-Chul ; Lee, You Mi ; Seo, Jun-Won ; Kim, Choon-Mee ; Yun, Na Ra ; Kim, Hyun-Chul ; Kim, Dong-Min

OBJECTIVETo describe a rare case of invasive fungal sinusitis caused by Malassezia restricta in a patient with diabetes and emphasize the diagnostic difficulties and significance of molecular techniques.STUDY DESIGNAn 85-year-old man with diabetes presented with unresolved left sphenoiditis despite a sphenoidotomy and antibiotics. Imaging findings indicated invasive fungal sinusitis. Pan-fungal polymerase chain reaction and sequencing along with special stains (Gomori methenamine silver and Periodic acid-Schiff) were used for the diagnosis.RESULTSAn initial pathological examination revealed necrotic tissue without visible fungal elements; fungal cultures were negative. Pan-fungal polymerase chain reaction identified M. restricta, and subsequent staining confirmed fungal invasion. The patient was treated with voriconazole, which led to a complete recovery and vision restoration.CONCLUSIONThis case highlights the value of molecular diagnostics and detailed pathological analysis in diagnosing rare fungal infections. The early and accurate identification of Malassezia infections allows effective treatment, ultimately improving patient outcomes.

18 Mar 2025·Skin Health and Disease

Erythematous variant of inverse pityriasis versicolor in skin of colour

Article

Author: Dodeja, Ajay ; Deoghare, Shreya

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