Last update 01 Nov 2024

Tinea Versicolor

Last update 01 Nov 2024

Basic Info

Synonyms

Infection by Malassezia furfur, Infection by Pityrosporum furfur, Infection, Malassezia furfur

+ [41]

Introduction

A common chronic, noninflammatory and usually symptomless disorder, characterized by the occurrence of multiple macular patches of all sizes and shapes, and varying in pigmentation from fawn-colored to brown. It is seen most frequently in hot, humid, tropical regions and is mostly caused by MALASSEZIA FURFUR (formerly Pityrosporum orbiculare).

Drugs associated with Tinea Versicolor

Bifonazole

Target

fungal CYP51A1

Mechanism

fungal CYP51A1 inhibitors

Active Org.

Originator Org.

Active Indication

Inactive Indication

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date08 May 2009

Tolnaftate

Target

Ergosterol

Mechanism

Ergosterol biosynthesis inhibitors

Active Org.

Choseido Pharmaceutical Co., Ltd.

Originator Org.

Choseido Pharmaceutical Co., Ltd.

Active Indication

Psoriasis [+2]

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date22 Mar 2007

Luliconazole

Target

fungal CYP51A1

Mechanism

fungal CYP51A1 inhibitors

Active Org.

Hainan Hailing Chemipharma Corp. Ltd. [+8]

Originator Org.

Nihon Nohyaku Co., Ltd.

Active Indication

Tinea Manus [+9]

Inactive Indication

Candidiasis, Chronic Mucocutaneous

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date11 Apr 2005

Clinical Trials associated with Tinea Versicolor

CTRI/2024/09/074285 / Not yet recruitingPhase 2IIT

A Comparative Clinical Trial on the Efficacy of Joshanda-e-Aftimoon orally along with Sheetraj and Sirka vs Khatmi and Sirka topically in Bahaq (Pityriasis Versicolor). - NIL

Start Date15 Oct 2024

Sponsor / Collaborator-

CTRI/2024/08/072927 / Not yet recruitingPhase 2/3IIT

Clinical Assessment Of Effect Of Cold Press Extracted Jyotishmati Taila (Seed Oil Of Celastrus Paniculatus Willd.) In Sidhma Kushta (Tinea Versicolour) And It’s Comparative Quality Standards Evaluation With Market Samples - NIL

Start Date01 Oct 2024

Sponsor / Collaborator-

IRCT20210823052264N8 / RecruitingPhase 3IIT

Efficacy of itraconazole in the prevention of recurrence of Pityriasis Versicolor

Start Date21 Aug 2024

Sponsor / Collaborator-

100 Clinical Results associated with Tinea Versicolor

100 Translational Medicine associated with Tinea Versicolor

0 Patents (Medical) associated with Tinea Versicolor

1,268

Literatures (Medical) associated with Tinea Versicolor

01 Dec 2024·Veterinary and Animal Science

Synergistic effect of essential oils and chlorhexidine against planktonic and biofilm-forming cells of Malassezia pachydermatis

Article

Author: Malinovská, Zuzana ; Čonková, Eva ; Váczi, Peter

Malassezia (M.) pachydermatis, is often associated with secondary infection of the skin and external auditory canal in dogs and cats. The treatment of Malassezia infections is based on the local application of antifungals often combined with antiseptics. Due to increased resistance of yeast to commonly used antimycotics, especially in biofilm-forming cells, the use of natural substances, e.g. plant essential oils, appears as a new promised option. In this study, the efficacy of selected plant essential oils (EO) - oregano, rosemary, bergamot, clove, cinnamon, and thyme - in combination with chlorhexidine on both planktonic and biofilm-forming cells of M. pachydermatis, was investigated. The checkerboard test was used to determine the effect of chlorhexidine combined with individual EOs. According to the FICI (fractional inhibitory concentration index) in planktonic cells, most combinations showed additive effect, except for thyme and rosemary EO, where a synergistic effect was found (33.3 % and 16.7 % respectively). In the biofilm-forming cells, a synergistic effect was noted in chlorhexidine combined with bergamot EO, recorded in 6 isolates (33.3 %), and with thyme and oregano EO, detected in 3 isolates (16.7 %). A significant decrease (p ˂ 0.05) was found in FIC (fractional inhibitory concentration) compared to MIC (minimum inhibitory concentration), for both planktonic and biofilm-forming cells. Based on the obtained results, we can conclude that the combination of chlorhexidine with EOs achieved better efficiency than when using each agent alone and made it possible to reduce the concentration of both, and a sufficient antifungal and antibiofilm effect was achieved in M. pachydermatis strains.

01 Dec 2024·IJID Regions

Skin mycosis distribution, and burden of visits over a decade in Colombia: ecological study

Article

Author: Teherán, Aníbal A ; Díaz, Laura C ; Camero-Ramos, Gabriel ; Hamann-Echeverri, Otto ; Pombo, Luis M. ; Zuluaga-Ortiz, Carol A ; Díaz, Laura C. ; Martínez, Nataly V ; Teherán, Aníbal A. ; Pombo, Luis M ; Ayala, Karen P ; Ayala, Karen P. ; Zuluaga-Ortiz, Carol A. ; Martínez, Nataly V.

ObjectivesTo describe the sociodemographic distribution of dermatomycosis and the visits burden over a 10-year period of care.MethodsAn ecological study was conducted using data on visits and people treated in the Colombian Health System during 2010-2019 using the International Classification of Diseases, Tenth Revision codes (ICD-10). Departments and geopolitical regions were the units of analysis, and visit burden was reported as frequency, intensity (visits per person), and rate of dermatomycosis visits (per 10,000 visits; 95% confidence interval).ResultsA total of 4,570,593 visits were analyzed. The most used ICD-10 codes were B369 (superficial mycosis, unspecified), B360 (pityriasis versicolor), B354 (Tinea corporis), B359 (dermatophytosis), and B351 (Tinea unguium) (56.5%), with visits primarily involving the adult population (27-59 years; 32.2%), women (43.4%), and urban populations (57.3%). Amazonas department had the highest rate of visits (2.36 per 10,000), while Nariño had the highest intensity of visits (1.94 visits per person). Caribbean region had the highest rate of visits (17.0 per 10,000 visits; 17.0-17.0), followed by the Amazon region (16.3 per 10,000 visits; 16.2-16.4).ConclusionsThe annual visits burden of dermatomycosis in Colombia is high and concentrated in susceptible geographic areas, possibly due to socio-environmental factors. This health problem is overshadowed by chronic diseases and trauma but is often recurrent, and chronic, and induces out-of-pocket costs for treatment.

01 Dec 2024·Fitoterapia

A greener side of health care: Revisiting phytomedicine against the human fungal pathogen Malassezia

Review

Author: Das, Shankar Prasad ; Sasikumar, Jayaprakash ; Keerthana, P.P. ; Naik, Bharati ; Jayaprakash ; P P, Keerthana

Malassezia species are commensal fungi residing on the skin and in the gut of humans and animals. Yet, under certain conditions, they become opportunistic pathogens leading to various clinical conditions including dermatological disorders. The emergence of drug resistance and adverse effects associated with conventional antifungal agents has propelled the search for alternative treatments, among which phytomedicine stands out prominently. Phytochemicals, including phenolic acids, flavonoids, and terpenoids, demonstrate potential antifungal activity against Malassezia by inhibiting its growth, adhesion, and biofilm formation. Furthermore, the multifaceted therapeutic properties of phytomedicine (including anti-fungal and, antioxidant properties) contribute to its efficacy in alleviating symptoms associated with Malassezia infections. Despite these promising prospects, several challenges hinder the widespread adoption of phytomedicine in clinical practice mostly since the mechanistic studies and controlled experiments to prove efficacy have not been done. Issues include standardization of herbal extracts, variable bioavailability, and limited clinical evidence. Hence, proper regulatory constraints necessitate comprehensive research endeavors and regulatory frameworks to harness the full therapeutic potential of phytomedicine. In conclusion, while phytomedicine holds immense promise as an alternative or adjunctive therapy against Malassezia, addressing these challenges is imperative to optimize its efficacy and ensure its integration into mainstream medical care. In this review we provide an update on the potential phytomedicines in combating Malassezia-related ailments, emphasizing its diverse chemical constituents and mechanisms of action.

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Tinea Versicolor

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