Delving into the Latest Updates on Arginine Butyrate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

HQK-1004, VX-105

Target

thymidine kinase

Mechanism

thymidine kinase stimulants(Thymidine kinase stimulants)

Therapeutic Areas

Digestive System DisordersEndocrinology and Metabolic DiseaseOther Diseases

Active Indication

Short Bowel Syndrome

Inactive Indication

Anemia, Sickle CellBeta-ThalassemiaEpstein-Barr virus positive Lymphoma+ [2]

Originator Organization

Boston University

Active Organization

Baxter Healthcare Corp.

Inactive Organization

Boston UniversityHemaQuest Pharmaceuticals, Inc.

Drug Highest PhasePreclinical

First Approval Date-

RegulationOrphan Drug (US)

Login to view timeline

Structure/Sequence

Molecular FormulaC10H22N4O4

InChIKeyHTWPXGKLFMPZHG-WCCKRBBISA-N

CAS Registry80407-72-3

OBJECTIVES: I. Determine whether arginine butyrate with or without epoetin alfa can stimulate gamma-globin chain production to a degree that decreases anemia and results in hematologic improvement in patients with thalassemia intermedia.
II. Determine whether a proportional increase in gamma-globin synthesis and mRNA and an improvement in nonalfa and alfaglobin chain imbalance by at least 10% over baseline correlate with improved hematologic response in these patients when treated with this regimen.
III. Determine whether a decrease in hemolysis, as assayed by a decrease in LDH, compared to baseline levels correlates with improved hematologic response in these patients when treated with this regimen.
IV. Determine whether any particular genotypes are more responsive than others to this therapy in these patients.
V. Determine whether baseline epoetin alfa levels, gender, and/or baseline reticulocyte counts (or percent circulating nucleated erythroblasts) correlate with improved hematologic response in these patients when treated with this regimen.

Start Date01 Mar 1999

Sponsor / Collaborator

Boston University

100 Clinical Results associated with Arginine Butyrate

Login to view more data

100 Translational Medicine associated with Arginine Butyrate

Login to view more data

100 Patents (Medical) associated with Arginine Butyrate

Login to view more data

111,037

Literatures (Medical) associated with Arginine Butyrate

31 Dec 2025·INTERNATIONAL JOURNAL OF FOOD PROPERTIES

FTIR characteristics of sweet flour as affected by particle size distribution and in vitro digestibility of gluten-free sweet potato noodles

Author: Mohamed Ahmed, Isam A. ; Aljobair, Moneera O. ; Anees Ur Rehman, Muhammad ; Azeem, Muhammad ; Wadood, Syed Abdul ; Qureshi, Tahir Mahmood ; Ali, Asmahan A.

There is a need to explore the influence of particle size of sweet potato flour on physicochem. properties and in vitro starch digestibility of gluten free sweet potato noodles.The aim of this work was to examine the influence of purple-fleshed sweet potato flour (PFSPF) having different particle size distribution (355 μm to 75μ m) on physicochem. properties and in vitro starch digestibility of gluten-free purple sweet potato noodles.Pasting properties and sugar contents were pos. correlated toward the finest particle fraction.The hardness of noodles was pos. and significantly correlated to the finest particle size fraction.Sweet potato flour (SPF) noodles prepared with particle size of 75 μm retained lower hardness 5.74 N.An abrupt increase in yellowness was observed with decreasing particle size that might be attributed to the reduction of protein.The results of FTIR suggested that with the reduction of particle size, protein and carbohydrates decreased that much associated with crystallization and retrogradation of starch.Among all the amino acids, aspartic acid and glutamic acid were observed to be more abundant, i.e. approx. 13.33 and 29.05‰, resp.In this way, PFSPF with particle size 75 μm exhibited significant application potential for producing gluten free noodles due to high resistant starch and lower hardness.It may be concluded that particle sizes of sweet potato flour influenced pasting properties, textural characteristics, sugar contents, protein contents, amino acid contents, carbohydrate contents of prepared noodles.

31 Dec 2025·Journal of the International Society of Sports Nutrition

Investigation of the effect of nitrate and L-arginine intake on aerobic, anaerobic performance, balance, agility, and recovery in elite taekwondo athletes

Article

Author: Ozan, Murat ; Buzdağlı, Yusuf ; Kavcı, Zafer ; Savaş, Adem ; Uçar, Halil

BACKGROUND:

Taekwondo is a complex martial art that requires speed, balance, agility, and endurance. This study aims to examine the effects of nitrate and L-arginine supplementation on acute aerobic and anaerobic performance, balance, agility, and recovery in elite taekwondo athletes.

METHOD:

This study was conducted as a double-blind, randomized, crossover study with the participation of 15 experienced taekwondo athletes aged 19.06 ± 0.96 years and 8.93 ± 1.27 years of training experience. Participants visited the laboratory a total of nine times, including a practice session and anthropometric measurements. These visits consisted of eight experimental sessions conducted at 72-hour intervals. The experimental sessions were conducted with nitrate, L-arginine, and a combination of both supplements (NIT*L-ARG) and placebo. Nitrate supplementation was provided by homogenizing fresh spinach (837.40 mg/kg), while L-ARG was given as a single dose of 6 g in powder form three hours before exercise.

RESULTS:

NIT*L-ARG supplementation significantly improved the anaerobic performance of athletes in Wingate peak power and peak power (w/kg) compared to placebo and in mean power compared to NIT, L-ARG, and PLA. In addition, NIT*L-ARG supplementation significantly improved blood lactate levels and agility performance immediately after Wingate and Shuttle run tests.

CONCLUSION:

The combined intake of NIT*L-ARG was found to be effective in improving aerobic, anaerobic, and agility performances as well as fatigue levels of athletes. It was determined that taking NIT and L-ARG supplements alone contributed to the improvement of improving athletes' performance in Wingate mean power values and subsequent fatigue level compared to PLA.

01 Dec 2025·Nano-Micro Letters

3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

Article

Author: Hong, Gaoying ; Chen, Yuewei ; Yuan, Ximin ; Kong, Weicheng ; He, Yong ; Yao, Ke ; Liu, Nian ; Zhou, Yanyan ; He, Jing ; Li, Yuanrong ; Xia, Pengcheng ; Hu, Zihe ; Xie, Zhijian ; Shi, Jue

Abstract:

Hydrogel scaffolds have numerous potential applications in the tissue engineering field. However, tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical properties. Inspired by Chinese ramen, we propose a universal fabricating method (printing-P, training-T, cross-linking-C, PTC & PCT) for tough hydrogel scaffolds to fill this gap. First, 3D printing fabricates a hydrogel scaffold with desired structures (P). Then, the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance (T). Finally, the training results are fixed by photo-cross-linking processing (C). The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa (622-fold untreated) and have excellent biocompatibility. Furthermore, this scaffold possesses functional surface structures from nanometer to micron to millimeter, which can efficiently induce directional cell growth. Interestingly, this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt, and many hydrogels, such as gelatin and silk, could be improved with PTC or PCT strategies. Animal experiments show that this scaffold can effectively promote the new generation of muscle fibers, blood vessels, and nerves within 4 weeks, prompting the rapid regeneration of large-volume muscle loss injuries.

100 Deals associated with Arginine Butyrate

Login to view more data

R&D Status

10 top R&D records.

Login

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Epstein-Barr virus positive Lymphoma	Phase 2	US	HemaQuest Pharmaceuticals, Inc.	01 May 2010
Epstein-Barr Virus-Related Lymphoma	Phase 2	US	HemaQuest Pharmaceuticals, Inc.	01 Sep 2008
Anemia, Sickle Cell	Phase 2	US	Boston University	01 Sep 1997
Beta-Thalassemia	Phase 2	US	Boston University	01 Sep 1997
Leg Ulcer	Phase 2	US	Boston University	01 Sep 1997
Short Bowel Syndrome	Preclinical	US	Baxter Healthcare Corp.	09 Mar 2023

Login to view more data

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00004412 (CTgov)	Phase 2	Beta-Thalassemia \| Leg Ulcer \| Anemia, Sickle Cell	23	Standard local care dressing (Standard Local Care Dressing)	aeccmttyxk(mylueqtzyw) = uciuweoifo gaunqlvexu (sbdmgjmcjt, xjrefzaaxw - mxxvytmtjv) View more	-	31 Mar 2015
NCT00004412 (CTgov)	Phase 2	Beta-Thalassemia \| Leg Ulcer \| Anemia, Sickle Cell	23	Standard local care dressing+Arginine Butyrate (Arginine Butyrate)	aeccmttyxk(mylueqtzyw) = anigumzhbc gaunqlvexu (sbdmgjmcjt, fyltitnqlc - lvtdtewxhp) View more	-	31 Mar 2015
Pubmed \| Br J Haematol	Phase 2	Leg Ulcer	-	Arginine Butyrate (Standard local care)	qwyfsrsvno(dyimsbsidq) = ljahjrqzwu zbxjwtvzqz (rhtlsedpte )	-	01 Dec 2010
Pubmed \| Br J Haematol	Phase 2	Leg Ulcer	-	Standard care with Arginine Butyrate	qwyfsrsvno(dyimsbsidq) = asisespsic zbxjwtvzqz (rhtlsedpte )	-	01 Dec 2010
Pubmed \| Blood	Phase 1/2	Epstein-Barr virus associated Neoplasms	15	Arginine butyrate	cclyzewdxo(byvzewijga) = btrnckhrqb lsiqdvomlt (umcsvsocrc )	-	15 Mar 2007
ASCO2006	Phase 1/2	Epstein-Barr virus associated Neoplasms	-	Arginine Butyrate	rdgmwavfyn(fhfydkpyhm) = leqbhzekti fsksppugyx (ighryxpvub )	-	20 Jun 2006