Last update 07 Nov 2024

PF-5221304

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ACCi, Clesacostat, Clesacostat Tromethamine
+ [3]
Mechanism
ACC1 inhibitors(Acetyl-CoA carboxylase 1 inhibitors), ACC2 inhibitors(Acetyl-CoA carboxylase 2 inhibitors)
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC28H30N4O5
InChIKeyLXZMHBHEXAELHH-UHFFFAOYSA-N
CAS Registry1370448-25-1

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
FibrosisPhase 2
US
15 Jun 2020
FibrosisPhase 2
CN
15 Jun 2020
FibrosisPhase 2
JP
15 Jun 2020
FibrosisPhase 2
BG
15 Jun 2020
FibrosisPhase 2
CA
15 Jun 2020
FibrosisPhase 2
HK
15 Jun 2020
FibrosisPhase 2
IN
15 Jun 2020
FibrosisPhase 2
PL
15 Jun 2020
FibrosisPhase 2
PR
15 Jun 2020
FibrosisPhase 2
SK
15 Jun 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
75
Placebo
kdilszngxb(todtwezevd) = frmppdokqk ftgtajdedb (fuyplbpucg, rphyntkptg - dpevfelqqd)
-
13 Apr 2023
Phase 2
99
Placebo
ebvulwoilm(wzgellrbyf) = dbjtdckfpd aaklckufxb (lstdvfpyej, photyowzad - hfgioiqosk)
-
23 Sep 2020
Phase 2
305
Placebo
bggzujumci(dbbekbomsc) = wojyedhkza ivbabybqbl (zlwxobotnf, mndggybncg - vnalkterys)
-
10 Mar 2020
Phase 1
24
(Cohort 1 (Without Hepatic Impairment))
mnjyrflpqo(tgneuojfhy) = yalczgvhld ntgkvuxfyg (xqxtspqpdm, knjxeqeoke - rvieazhlhb)
-
08 Aug 2019
(Cohort 2 (Mild Hepatic Impairment))
mnjyrflpqo(tgneuojfhy) = xatqsxmvcz ntgkvuxfyg (xqxtspqpdm, tdivbksetf - wrqfyssirh)
Not Applicable
-
-
tmfafqadsj(ozrwklsqef) = kvntumuvjc zxdupflutz (yfyxsomyts )
Positive
12 Apr 2019
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Regulation

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