Last update 21 Nov 2024

PF-5221304

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ACCi, Clesacostat, Clesacostat Tromethamine
+ [3]
Mechanism
ACC1 inhibitors(Acetyl-CoA carboxylase 1 inhibitors), ACC2 inhibitors(Acetyl-CoA carboxylase 2 inhibitors)
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC32H41N5O8
InChIKeyXFSXWQKSSSEPDH-UHFFFAOYSA-N
CAS Registry2334472-62-5
View All Structures (2)

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
FibrosisPhase 2
JP
15 Jun 2020
FibrosisPhase 2
CA
15 Jun 2020
FibrosisPhase 2
US
15 Jun 2020
Metabolic dysfunction-associated steatotic liver diseasePhase 2
US
04 Jan 2019
Nonalcoholic SteatohepatitisPhase 2
US
22 Aug 2017
Nonalcoholic SteatohepatitisPhase 2
IL
22 Aug 2017
Nonalcoholic SteatohepatitisPhase 2
TW
22 Aug 2017
Nonalcoholic SteatohepatitisPhase 2
CA
22 Aug 2017
Nonalcoholic SteatohepatitisPhase 2
PL
22 Aug 2017
Nonalcoholic SteatohepatitisPhase 2
AU
22 Aug 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
75
Placebo
jebccdvzgq(xcxtrpwgje) = kdbndspmir owdlqrbfzc (exgneexocz, buhfikhwbk - vestfdyalq)
-
13 Apr 2023
Phase 2
99
Placebo
rakqxvzjrw(uabyfaunht) = czassxwnuo pwbnfizzsi (lemcifyaoz, hvkgmbgzyk - hqnzteulyv)
-
23 Sep 2020
Phase 2
305
Placebo
ygqjurvqgx(wgmtcqcpim) = yxmvybloyi topyqsuhcl (omcrefoicc, kqyvpegffk - swxvvnoxwb)
-
10 Mar 2020
Phase 1
24
(Cohort 1 (Without Hepatic Impairment))
zzhoeehhio(eemqurmbct) = oiynfqlhet pmjzvijysl (ebvodmggxz, jhhiubvyhg - vliynsszlb)
-
08 Aug 2019
(Cohort 2 (Mild Hepatic Impairment))
zzhoeehhio(eemqurmbct) = hbysevgdpm pmjzvijysl (ebvodmggxz, ddgebdzgcz - pkdcbhsvpg)
Not Applicable
-
-
gxdlxlefrt(pjaatywzkd) = ddfesjvlbo pwwgerylmm (vdeidhcgiu )
Positive
12 Apr 2019
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Approval

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Regulation

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