According to the randomized self-controlled double 3×3 Latin square experimental design, oral allantoin aluminum granules, allantoin aluminum granules (sold) and placebo were administered. The allantoin blood concentration in plasma after oral administration of the two preparations was measured, the pharmacokinetic parameters were calculated, and the absorption rate and absorption extent were compared to evaluate the bioequivalence of the two preparations.

Start Date18 Aug 2012

Sponsor / Collaborator

Northern Pharmaceutical Industry Co.,Ltd.

[+1]

100 Clinical Results associated with Aldioxa

100 Translational Medicine associated with Aldioxa

100 Patents (Medical) associated with Aldioxa

Literatures (Medical) associated with Aldioxa

01 Jun 2009·Quintessence international (Berlin, Germany : 1985)Q4 · MEDICINE

Anticalculus efficacy of a new dentifrice.

Q4 · MEDICINE

Article

Author: Vento, Cristina ; Llena, Carmen ; Forner, Leopoldo

OBJECTIVEThe Volpe and Manhold Index (VMI) was used to evaluate the anticalculus efficacy of the dentifrice Fluor Kin antisarro, used on adults twice a day for 2 minutes over 3 months, in comparison with the dentifrice Lacer.METHOD AND MATERIALSA clinical study in which 48 adults took part was designed. The presence of calculus was determined at baseline (VMI), a tartrectomy was performed, and the patients were instructed to brush their teeth twice a day for 2 minutes, using a medium-bristled toothbrush with a commercial dentifrice containing 0.2% aldioxa and 1.9% sodium monofluorophosphate. Three months later, VMI was determined again. After 2 weeks, a new tartrectomy was performed on the same patients, and the subjects were instructed to brush their teeth as before, this time with the study dentifrice based on 0.32% sodium fluoride, 4.1% tetrapotassium pyrophosphate, 2.0% PVM/MA (methylvinylether/maleic acid) copolymer (Gantrez S), 1.0% provitamin B5, and 0.2% vitamin B3. After an additional 3 months, dental calculus was determined again.RESULTSThe study dentifrice showed a significant reduction in VMI in relation to the initial situation (P = .009). There were also significant differences in VMI values between the 2 dentifrices (P = .010). VMI differences were not significant for either dentifrice when analyzed by gender, tobacco use, and toothbrushing frequency before starting the study.CONCLUSIONSBrushing twice a day for 2 minutes with Fluor Kin antisarro effectively reduces supragingival calculus.

01 Jan 1994·Folia Pharmacologica Japonica

Acidified aspirin-induced gastric lesion in rats with hepatic cirrhosis produced by N-nitrosodiethylamine or carbon tetrachloride. Effect of aldioxa on gastric lesions.

Article

Author: Uchida, Masayuki ; Hamura, Hiroki ; Shibata, Hiroko ; Takagi, Satoshi ; Honda, Hideo ; Noguchi, Yuji

Gastric lesion was induced by the oral administration of acidified aspirin in rats with hepatic cirrhosis produced by N-nitrosodiethylamine (NDA) or carbon tetrachloride (CCl4). Gastric lesion by acidified aspirin was aggravated in NDA-induced cirrhosis, but not in CCl4-cirrhotic rats. To clarify this difference in the susceptibility of the gastric mucosa, gastric mucosal blood flow and gastric emptying were measured by the hydrogen gas clearance method and beads method, respectively. Gastric mucosal blood flow was lower and gastric emptying was significantly delayed in NDA-induced cirrhotic rats as compared with the controls, but not in CCl4-induced cirrhotic rats. Gastric mucosal blood flow in NDA-induced cirrhotic rats was significantly decreased by the oral administration of acidified aspirin as compared with the controls. Aldioxa dose-dependently inhibited the gastric lesion formation by acidified aspirin and inhibited the decrease of gastric mucosal blood flow in NDA-induced cirrhotic rats. These results suggest that aggravation of gastric lesion induced by acidified aspirin in NDA-induced cirrhotic rats would be due to the decrease of gastric mucosal blood flow and delay of gastric emptying. In addition, aldioxa showed a protective effect against gastric lesions induced by acidified aspirin in NDA-induced cirrhotic rats, suggesting that this compound would have an inhibitory effect on gastric lesions that are accompanied by hepatic cirrhosis.

01 Jan 1990·Folia Pharmacologica Japonica

The effect of aldioxa on the formation of gastritis induced with sodium hydroxide.

Article

Author: Misaki, Noriyuki ; Bando, Kazuyoshi ; Uchida, Masayuki ; Ohbayashi, Shigeo ; Kawano, Osamu

The effects of aldioxa and cetraxate hydrochloride on the formative process of gastritis induced with intragastric application of 2% sodium hydroxide were studied. Rats were given food including either aldioxa or cetraxate hydrochloride for 6 weeks after the sodium hydroxide application. After sacrifice, the stomachs were removed, and the gastric mucosa were observed macroscopically and histologically. Gastric mucosal injury was widely induced with sodium hydroxide, being histologically characterized by mucosal hypertrophy, cell infiltration and intestinal metaplasia. These lesions seem to be the early stage of chronic gastritis. The aldioxa group showed a decrease of mucosal hypertrophy and cell infiltration as compared with the control group. In the cetraxate hydrochloride group, the mucosal surface of white gray color and the mucosal bosselation were observed macroscopically. Histologically, these were found to be cell infiltration and cyst formation. Moreover, intestinal metaplasia occurred at high incidence in this group. These findings in the cetraxate hydrochloride group are recognized to be an aggravation of chronic gastritis. From the above results, it is suggested that aldioxa promotes good regeneration of mucosa and should be useful for the clinical therapy of chronic gastritis.

100 Deals associated with Aldioxa

External Link

KEGG	Wiki	ATC	Drug Bank
D02033	Aldioxa	A02B	-

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Duodenal Ulcer	CN	-	-
Stomach Ulcer	CN	-	-

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Duodenal Ulcer	Phase 1	CN	Northern Pharmaceutical Industry Co.,Ltd.	18 Aug 2012
Duodenal Ulcer	Phase 1	CN	Taisho Pharmaceutical Co., Ltd.	18 Aug 2012
Gastritis	Phase 1	CN	Northern Pharmaceutical Industry Co.,Ltd.	18 Aug 2012
Gastritis	Phase 1	CN	Taisho Pharmaceutical Co., Ltd.	18 Aug 2012
Stomach Ulcer	Phase 1	CN	Taisho Pharmaceutical Co., Ltd.	18 Aug 2012
Stomach Ulcer	Phase 1	CN	Northern Pharmaceutical Industry Co.,Ltd.	18 Aug 2012

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