EGFR modulators(Epidermal growth factor receptor erbB1 modulators), MAPKs modulators(Mitogen-activated protein kinase modulators), Proto-oncogene proteins c-akt modulators(Proto-oncogene proteins c-akt modulators)

Therapeutic Areas

Infectious DiseasesDigestive System DisordersNeoplasms+ [1]

Active Indication

Hepatitis B, ChronicSecondary malignant neoplasm of pancreas

Inactive Indication

Colorectal CancerCOVID-19Dermatitis, Atopic+ [5]

Originator Organization

Golden Biotechnology Corp.

Active Organization

Golden Biotechnology Corporation

Inactive Organization

Golden Biotechnology Corp.China Sky One Medical, Inc.

Drug Highest PhasePhase 2

First Approval Date-

RegulationOrphan Drug (US), Orphan Drug (EU)

Structure

Molecular FormulaC24H38O4

InChIKeyLJTSIMVOOOLKOL-FNRDIUJOSA-N

CAS Registry1010081-09-0

Clinical Trials associated with Antroquinonol

NCT04523181 / CompletedPhase 2

A Phase 2 Randomized, Double-blind, Placebo-controlled, Proof of Concept Study to Evaluate the Safety and Efficacy of Antroquinonol in Hospitalized Patients With Mild to Moderate Pneumonia Due to COVID-19

To evaluate the safety and efficacy of antroquinonol treatment of mild to moderate pneumonia due to COVID-19, as measured by the proportion of patients alive and free of respiratory failure.

Start Date15 Oct 2020

Sponsor / Collaborator

Golden Biotechnology Corporation

NCT03823352 / CompletedPhase 2

Open-label, Non-randomized, Phase IIa Study to Evaluate Efficacy and Safety/Tolerability Profiles of Antroquinonol in Adult Patients With Relapsed Acute Myeloid Leukemia (AML) or at Initial Diagnosis When no Intensive Treatment is Possible

This is a IIa phase IIa open-label, non-randomized clinical trial of Antroquinonol, capsule, 100 mg (Golden Biotechnology Corporation, Taiwan) in patients with AML.

Start Date20 Feb 2019

Sponsor / Collaborator

Golden Biotechnology Corporation

NCT04112147 / Unknown statusPhase 2IIT

A Randomized, Double-Blind, Dosing-Ranging, Placebo-controlled Trial of Antroquinonol in Patients With Chronic Hepatitis B

Primary Objective:
To evaluate the activity of Antroquinonol in patients with chronic hepatitis B
Secondary Objective:
To assess the mechanism and cytokines change of Antroquinonol in patients with chronic hepatitis B

Start Date10 Aug 2018

Sponsor / Collaborator

Chung Shan Medical University

[+1]

100 Clinical Results associated with Antroquinonol

100 Translational Medicine associated with Antroquinonol

100 Patents (Medical) associated with Antroquinonol

Literatures (Medical) associated with Antroquinonol

19 Jul 2023·Life (Basel, Switzerland)

A Review of the Potential Benefits of Herbal Medicines, Small Molecules of Natural Sources, and Supplements for Health Promotion in Lupus Conditions.

Review

Author: Kozuharova, Ekaterina ; Tavakoli, Ali ; Hamedi, Azadeh ; Hassani, Bahareh ; Pasdaran, Ardalan

The Latin word lupus, meaning wolf, was in the medical literature prior to the 1200s to describe skin lesions that devour flesh, and the resources available to physicians to help people were limited. The present text reviews the ethnobotanical and pharmacological aspects of medicinal plants and purified molecules from natural sources with efficacy against lupus conditions. Among these molecules are artemisinin and its derivatives, antroquinonol, baicalin, curcumin, emodin, mangiferin, salvianolic acid A, triptolide, the total glycosides of paeony (TGP), and other supplements such as fatty acids and vitamins. In addition, medicinal plants, herbal remedies, mushrooms, and fungi that have been investigated for their effects on different lupus conditions through clinical trials, in vivo, in vitro, or in silico studies are reviewed. A special emphasis was placed on clinical trials, active phytochemicals, and their mechanisms of action. This review can be helpful for researchers in designing new goal-oriented studies. It can also help practitioners gain insight into recent updates on supplements that might help patients suffering from lupus conditions.

16 Feb 2023·Natural product researchQ3 · CHEMISTRY

Chemical investigations and cytotoxic effects of metabolites from Antrodia camphorata against human hepatocellular carcinoma cells

Q3 · CHEMISTRY

Article

Author: Chen, Yih-Fung ; Wu, Ho-Cheng ; Chang, Hsun-Shuo ; Lin, Chu-Hung ; Ko, Horng-Huey ; Chang, Jia-Min

Antrodia camphorata is used as a medicinal fungus in Taiwan to treat fatigue, food intoxication, and enhance liver function. Here we identified fermented metabolic components from the mycelium of A. camphorata KH37 and explored their anti-hepatoma potentials with study models of human hepatoblastoma cell lines. Bioassay-guided fractionation of the solid fermentation powder of A. camphorata KH37 led to the isolation of one new quinonol, antroquinonol Z (1), and nine known compounds (2-10). Treatment with 10 μM antrocamols LT1 (2) or LT3 (3) reduced cell viability of HepG2 and Huh-7 cells to about 60% in 48 hours. Antroquinonol Z (1) exhibited mild cytotoxicity against Huh-7 cells in 48 and 72 hours. Interestingly, two fractions showed cytotoxicity in HepG2 and Huh-7 cells, even better than compounds isolated from these fractions. The significant cytotoxicity of partially purified samples from A. camphorata KH37 exhibited a potential for developing alternative or complementary therapeutics against hepatoma.

01 May 2022·Brain, behavior, & immunity - health

Antroquinonol administration in animal preclinical studies for Alzheimer's disease (AD): A new avenue for modifying progression of AD pathophysiology

Article

Author: Sarah, Lye ; Caitlin, Aust ; Robyn, Griffiths Lyn ; Francesca, Fernandez

Despite the rise of Alzheimer's disease (AD) in an ageing population, no cure is currently available for this disorder. This study assessed the role of a natural compound, Antroquinonol, in modifying the progression of AD when administered at the start and/or before appearance of symptoms and when the disease was well established, in a transgenic animal model. Antroquinonol was administered daily for 8 weeks, in 11 week (early stage) and 9 month (late stage) male transgenic mice (3 times Transgenic mice PS1_M146V, APP_Swe, and tau_P301L, 3 Tg XAD) and their respective aged controls. Behavioural testing (including Elevated Plus Maze Watermaze, Recognition object testing and Y maze) was performed at the end of the drug administration. In addition AD biomarkers (Amyloid beta 42 (Aβ42), tau and phospho-tau levels), oxidative stress and inflammatory markers, were assessed in tested mice brains after their sacrifice at the end of the treatment. When administered before the start of symptoms at 11 weeks, Antroquinonol treatment at 34 mg/kg (D2) and more consistently at 75 mg/kg (D3), had a significant effect on reducing systemic inflammatory markers (Interleukin 1, IL-1β and TNF-α) and AD biomarker (Amyloid Beta 42, Aβ42 and tau) levels in the brain. The reduction of behavioural impairment reported for 3TgXAD mice was observed significantly for the D3 drug dose only and for all behavioural tests, when administered at 11 weeks. Similarly, beneficial effects of Antroquinonol (at higher dose D3) were noted in the transgenic mice in terms of AD biomarkers (tau and phosphorylated-tau), systemic inflammatory (IL-1β), brain anti-inflammatory (Nrf2) and oxidative (3-Nitrotyrosine, 3NT) markers. Improvement of memory impairment was also reported when Antroquinonol (D3) was administered at late stage (9 months). Since Antroquinonol has been used without adverse effects in previous successful clinical trials, this drug may offer a new avenue of treatment to modify AD development and progression.

News (Medical) associated with Antroquinonol

18 Jan 2024

·www.fiercebiotech.com

Mushroom-derived drug posts improved survival data in Golden Biotech’s pancreatic cancer trial

Pancreatic cancer. Golden Biotechnology has shared updated data on its mushroom-derived drug candidate in metastatic pancreatic cancer, linking first-line use of the molecule to median overall survival (OS) of 14.1 months. People with metastatic pancreatic cancer lack good options, to the extent that the National Institutes of Health recommends that all newly diagnosed patients should consider enrolling in clinical trials. Chemotherapy remains the least bad option for many patients, with the FOLFIRINOX cocktail and gemcitabine-nab-paclitaxel combination respectively chalking up median OS figures of 11.1 months and 8.5 months. Another chemotherapy regimen, NALIRIFOX, also achieved a median OS of 11.1 months last year. Golden Biotech is presenting data on its attempt to clear that OS bar at the American Society of Clinical Oncology Gastrointestinal Cancers Symposium this week. The median OS in metastatic pancreatic cancer patients who received its drug antroquinonol, along with gemcitabine and nab-paclitaxel as a first-line treatment was 14.1 months. Median progression-free survival clocked in at 5.3 months. The OS has increased since an earlier look at the data, when it came in at 12.6 months. In 2014, an ASCO committee said a 4-5 month improvement over FOLFIRINOX, or 3-4 month edge over gemcitabine-nab-paclitaxel, would be clinically meaningful. Research suggests more patients are eligible for gemcitabine-nab-paclitaxel than the more effective FOLFIRINOX. In the absence of a control arm, it is impossible to tell whether adding antroquinonol to the treatment mix improves on the OS achieved by chemotherapy. Investors appeared unmoved, with little change in the Taiwanese biotech’s share price on the Taipei Exchange. Golden Biotech’s statement lacks a close look at the safety and tolerability results. An earlier cut of the data showed the rates of neutropenia, thrombocytopenia and anemia were lower in the antroquinonol group than in an earlier chemotherapy trial, although the rates of vomiting and diarrhea were higher. Antroquinonol is a ubiquinone derivative found in a mushroom that grows on a tree of Taiwan. Evidence that the molecule blocks RAS signaling has spurred Golden Biotech to advance the molecule in pancreatic cancer. Other biotechs are going after the cancer by targeting KRAS, NTRK fusions, RET and other drivers of pancreatic tumors.

Clinical ResultASCOPhase 3

18 Jan 2024

·www.biospace.com

ASCO GI 2024: Golden Biotech's Antroquinonol Shows Significantly Prolonged Survival in Untreated Metastatic Pancreatic Cancer Patients

TAIPEI, Jan. 18, 2024 /PRNewswire/ -- Golden Biotechnology Corp.(TPEX 4132) ("GoldenBiotech", GBC), an advanced biopharmaceutical drug development company, had unveiled the findings of its Phase II clinical trial investigating Antroquinonol (HOCENA) in combination with the standard of care (SOC): nab-paclitaxel + gemcitabine, as first-line treatment for metastatic pancreatic cancer. The trial showed a positive median overall survival (mOS) of 14.1 months, which is a substantial increase compared to 8.5 months mOS observed in the standard of care Phase III clinical study (nab-paclitaxel + gemcitabine). Notably, when compared to current first-line treatment options for this very difficult to treat cancer, there was a highly significant survival advantage of patients treated with oral Antroquinonol in combination with SOC. Metastatic Pancreatic Cancer remains a devastating disease with very low survival rate and significant unmet medical needs in terms of treatment options. The ASCO Gastrointestinal Cancers Symposium 2024 Committee has selected Golden Biotech's Phase 2 Study, titled "A Phase I/II study of Antroquinonol in combination with Nab-Paclitaxel and Gemcitabine for patients with metastatic pancreatic cancer," for poster presentation. This multinational study, registered under NIH Clinical Trial Registration Number NCT03310632, employed a single-arm, open-label design with participating sites in the United States, South Korea, and Taiwan. The study revealed clinically meaningful responses in subjects treated with Antroquinonol in combination with the standard of care. The treatment demonstrated significantly longer overall survival (median OS) and OS rates at both 6 and 12 months when compared to the standard of care Phase III study. The OS figures were 14.1, 8.5, and 6.7 months for (Antroquinonol + nab-paclitaxel + gemcitabine), (nab-paclitaxel + gemcitabine), and gemcitabine alone, respectively. The corresponding OS rates at 6 months were 85.5%, 67%, and 55%, while the rates at 12 months were 62.2%, 35%, and 22%. In addition, Antroquinonol in combination with the standard of care surpassed the efficacy of another chemotherapy regimen, FOLFIRINOX, in terms of median OS and OS rates (Antroquinonol + standard of care vs FOLFIRINOX: OS= 14.1 vs 11.1 months; OS rate at 6 months=85.5% vs 76%; OS rate at 12 months=62.2% vs 48%). The trial results also showed an mPFS of 5.3 months and a 6-month PFS rate of 41.7% for Antroquinonol in combination with the standard of care drugs. The American Society of Clinical Oncology (ASCO) Committee have defined Clinically Meaningful Goals for clinical trials in Pancreas, Breast, Lung, and Colorectal Cancers. For Pancreatic Cancer patients eligible for treatment with Gemcitabine or Gemcitabine/Nab-paclitaxel, the current baseline median overall survival is estimated to range from 8 to 9 months. It is considered "clinically meaningful" if the minimum improvement over current overall survival is between 3 to 4 months. Golden Biotech's Antroquinonol has gained recognition for its groundbreaking work in the field of cancer treatment. It has been granted Orphan Drug Designation (ODD) by the FDA for the treatment of Pancreatic Cancer, Acute Myeloid Leukemia (AML), and Hepatocellular Carcinoma (liver cancer), as well as ODD by the EMA for Pancreatic Cancer. These acknowledgments underscore the potential of Antroquinonol in addressing the high-unmet medical needs associated with these challenging diseases. When compared to gemcitabine and other existing first-line therapies for metastatic pancreatic cancer, Antroquinonol in combination with the standard of care exhibited a significant survival advantage. Additionally, hematological adverse events (AEs) induced by nab-paclitaxel and gemcitabine, such as neutropenia, thrombocytopenia, anemia, and leukopenia, were substantially improved across all grade levels. No additional safety concerns were observed during the study. By combining nab-paclitaxel and gemcitabine with Antroquinonol, the incidence of hematological side effects also decreased across all grades. The results of this clinical trial may be a potential game changer for metastatic pancreatic cancer. Antroquinonol in combination with the standard of care may provide patients with significantly improved median overall survival and reduced hematological side-effects. Providing new hope for patients everywhere, for this very difficult to treat cancer FORWARD-LOOKING STATEMENTS: The statements contained herein may contain certain forward-looking statements relating to Golden Biotechnology Corporation (the "Company") that are based on the current beliefs and expectations of the Company's management as well as assumptions made by and information currently available to the Company's management. These forward-looking statements include, but are not limited to, statements relating to the Company's business prospects, future developments, trends and conditions in the industry and geographical markets in which the Company operates; the Company's inventions, patents, patent applications, strategies, plans, objectives and goals; the Company's ability to control costs; and statements relating to prices, volumes, operations, margins, overall market trends, risk management and exchange rates. These statements can be identified by the use of words such as "anticipate," "estimate," "believe," "continue," "could," "intend," "may," "plan," "potential," "predict," "should," "seek," "will," "expect," "objective," "projection," "forecast," "goal," "guidance," "outlook," "effort," "target" or the negative of these terms or other comparable terms. However, the absence of these words does not mean that the statements are not forward-looking. These forward-looking statements are, by their nature, subject to significant risks and uncertainties. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements. These forward-looking statements speak only as of the date hereof, and the Company undertakes no obligation to update or reflect subsequent events or circumstances, changes in expectations or the occurrence of unanticipated events. All forward-looking statements herein are qualified by these cautionary statements and there can be no assurance that the actual results or anticipated developments will be realized or, even if substantially realized, that they will have the expected consequence to or effects on the Company's business or operations. View original content to download multimedia: SOURCE Golden Biotechnology Corp. Company Codes: Gretai:4132, Taiwan:4132.TWO, Taiwan:4132

Clinical ResultASCOOrphan DrugPhase 2Phase 3

05 May 2023

·www.drugs.com

Phase 2 Trial Results for Antroquinonol as 1st Line Treatment for Stage 4 Metastatic Pancreatic Cancer

TAIPEI, May 5, 2023. Golden Biotechnology Corp. ("GoldenBiotech," GBC), an advanced biopharmaceutical drug development company, announces the release of positive interim results from its Phase II clinical trial of Antroquinonol (HOCENA) in combination with the standard of care (SOC) nab-paclitaxel + gemcitabine for first-line treatment of metastatic pancreatic cancer. The median overall survival (mOS) was 12.6 months, which was 48% better than the 8.5 months mOS in the Phase III clinical study of the standard of care (nab-paclitaxel + gemcitabine). Compared to the current first-line treatments for this difficult-to-treat cancer, this study demonstrated that Antroquinonol in combination with SOC showed a significant survival advantage. The Phase II Antroquinonol clinical trial is a single-arm Phase I/II study to evaluate the safety and efficacy of Antroquinonol in combination with SOC (nab-paclitaxel + gemcitabine) as a first-line treatment for stage IV metastatic pancreatic cancer. The first stage of the study focused on treating pancreatic cancer with oral Antroquinonol at doses of 200 mg three times daily and 300 mg three times daily for a duration of 4 weeks; to determine the maximum tolerated dose regimen for Antroquinonol in combination with SOC. The expanded Phase II trial will focus on the efficacy of Antroquinonol in combination with SOC. This is a multi-national and multi-center clinical trial enrolling patients in the United States, Taiwan and South Korea. The interim report on the metastatic pancreatic cancer trial (Full Analysis Set) demonstrated clear clinical benefits for patients treated with Antroquinonol together with SOC. Key Results : * Median progression-free survival (mPFS): 5.3 months * Median overall survival (mOS): 12.6 months * Six-month overall survival rate (OS rate): 86% * Twelve-month overall survival rate (OS rate): 60% Compared to the results of the Phase III study for the SOC (nab-paclitaxel + gemcitabine combination), Antroquinonol in combination with SOC has much better median overall survival (mOS), six-month and twelve-month overall survival rates (OS rates). The overall survival rates for Antroquinonol combination therapy, standard treatment (nab-paclitaxel + gemcitabine), and gemcitabine monotherapy were 12.6, 8.5 and 6.7 months respectively; six-month overall survival rates were 86%, 67% and 55% respectively; and twelve-month overall survival rates were 60%, 35% and 22% respectively. In comparison to the FOLFIRINOX treatment for metastatic pancreatic cancer, in terms of median overall survival and six-months overall survival rates; again the Antroquinonol in combination with SOC demonstrated superiority. Data showed that the overall survival (OS) between Antroquinonol combination with SOC and FOLFIRINOX were 12.6 and 11.1 months respectively; six-month overall survival rates were 86% and 76% respectively; twelve-month overall survival rates were 60% and 48% respectively. Compared to current first-line treatments, Antroquinonol in combination with SOC has also demonstrated better survival advantage. Existing SOC for pancreatic cancer frequently causes adverse events that can result in disruptions to treatments. For Antroquinonol combination with SOC, blood-related adverse events, including neutropenia, thrombocytopenia, anemia and leukopenia, were significantly reduced in all grades in this trial. For non-hematologic adverse events such as fatigue, hair loss, peripheral neuropathy and dehydration; the events were similarly reduced in the Antroquinonol combination. The phase 2 study of Antroquinonol in combination with SOC demonstrates the high possibility of a new first-line agent for the treatment of Stage 4 metastatic pancreatic cancer. With its oral formulation and low side-effects, Antroquinonol can be an exciting addition to the current IV chemotherapies and immediately offer patients the possibilities of better treatment outcomes. Alex Liu, Chairman of Golden Biotech, said: " The results of this interim analysis is exceptionally encouraging. Antroquinonol in combination with standard treatment appears to have a significant survival advantage over current first-line treatments for metastatic pancreatic cancer. Patients on Antroquinonol also demonstrated reduced adverse event which significantly improve their quality of life. We look forward to continuously monitoring the patients to evaluate if the results can be sustained. Overall, for many years, there have been no new treatments for this difficult-to-treat cancer. Antroquinonol may be the treatment that offers new hope to pancreatic cancer patients." Antroquinonol is a new chemical entity (NCE) with multiple functions. It has been developed that shows promising results in the treatment of cancers. Antroquinonol inhibited Ras and Ras-related GTP-binding protein activation through inhibition of protein isoprenyl transferase activity, leading to activation of autophagy and associated mode of cell death in cancer cells. More than 30 percent of all human cancers including 95% of pancreatic cancers are driven by mutations of the RAS family of genes. Antroquinonol also has impacts on the PI3K/ AKt / mTOR pathway, affecting the autophagy and apoptosis of cancer cells. Its ability to target cancer cells without harming normal cells reduces the likelihood of drug resistance and increases its safety profile. Additionally, it can be taken orally, providing a convenient treatment option for patients. It may represent a significant advancement in the treatment of pancreatic cancer with its multiple functions and high safety profile. The global pancreatic cancer treatment market size was $2.15 billion in 2021 and is expected to grow from $2.48 billion in 2022 to $6.85 billion in 2029 at a compound annual growth rate of 15.7%. This growth is being driven by the increasing incidence of pancreatic cancer, the growing demand for personalized cancer therapies, and the rising adoption of innovative therapies. The results of this clinical trial could have a major impact on the treatment of metastatic pancreatic cancer. If these results are confirmed in future studies, Antroquinonol in combination with standard treatment could challenge to be the new standard of care for this devastating disease. SOURCE Golden Biotechnology Corp. Posted: May 2023

Clinical ResultPhase 2Phase 3ASCO

100 Deals associated with Antroquinonol

External Link

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB12326

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
COVID-19	Phase 2	US	Golden Biotechnology Corporation	15 Oct 2020
COVID-19	Phase 2	AR	Golden Biotechnology Corporation	15 Oct 2020
COVID-19	Phase 2	PE	Golden Biotechnology Corporation	15 Oct 2020
Relapsing acute myeloid leukemia	Phase 2	RU	Golden Biotechnology Corporation	20 Feb 2019
Hepatitis B, Chronic	Phase 2	TW	Golden Biotechnology Corporation	01 Aug 2018
Hepatitis B	Phase 2	TW	Golden Biotechnology Corp.	13 Jul 2018
Dermatitis, Atopic	Phase 2	TW	Golden Biotechnology Corp.	30 Jun 2018
Pancreatic Cancer	Phase 2	CN	Golden Biotechnology Corp.	01 Dec 2017
Secondary malignant neoplasm of pancreas	Phase 2	US	Golden Biotechnology Corporation	01 Dec 2017
Secondary malignant neoplasm of pancreas	Phase 2	KR	Golden Biotechnology Corporation	01 Dec 2017

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NEWS Manual	Phase 2	Pancreatic Cancer	-	Antroquinonol+白蛋白结合型紫杉醇+吉西他滨	nsnlgikvkz(lvdrqjzbpi) = pjkqppafhj bdhlfbxols (bpzzwijkgc ) View more	Positive	19 Jan 2024
				白蛋白结合型紫杉醇+吉西他滨	nsnlgikvkz(lvdrqjzbpi) = tiophhuopr bdhlfbxols (bpzzwijkgc ) View more
NCT04523181 (CTgov)	Phase 2	COVID-19	124	Antroquinonol (Antroquinonol With SOC)	wgflbrjrld(vrpjgfkoui) = rziuzvvrzv hncsnwwrvy (kuiuzmvhbg, kjschxnary - yonyslbyhw) View more	-	13 Dec 2023
				Placebo (Placebo With SOC)	wgflbrjrld(vrpjgfkoui) = bmpcrzvbvo hncsnwwrvy (kuiuzmvhbg, zlnxgjdhrd - hhdojkpfgj) View more
PRNewswire Manual	Phase 2	COVID-19	124	Antroquinonol	xwhkasgbsc(tpvfblycul) = hyztlrjmtq jlxzhnuqlu (jaoceozqpe ) View more	Positive	07 Jan 2022
				Placebo	-
NCT03823352 (GHAML-2-001, ASCO2021)	Phase 2	Relapsing acute myeloid leukemia	12	Antroquinonol 200 mg BID	cwdmbjleny(gxwxbpxtta) = wruapecxnb edsedyaseu (qtstqqytym )	Positive	28 May 2021
NCT02719028 (CTgov)	Phase 2	Hypercholesterolemia	120	placebo (Placebo)	ioanjuhpqc(wdyttkevzy) = gqvmmphsgz oapwckqidf (wdlbtbvqgp, nbeyibfgtg - mmgjkinclg) View more	-	20 Dec 2019
				placebo+Antroquinonol (Antroquinonol 50 mg PO)	ioanjuhpqc(wdyttkevzy) = uuynqqtkst oapwckqidf (wdlbtbvqgp, yqkkcxpteb - dfalpoakob) View more
NCT02047344 (ASCO2019) Manual	Phase 2	Non-Small Cell Lung Cancer Last line	30	antroquinonol (2 prior chemotherapy)	grcriexnuc(ygzupateaz) = enowsmiuyf dlgqivtazh (eynqffeaiz, 5.0 - 31.1)	Positive	31 May 2019
				antroquinonol (more than 2 prior chemotherapy)	grcriexnuc(ygzupateaz) = lhhrywuetq dlgqivtazh (eynqffeaiz, 6.0 - 14.1) View more

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