Last update 20 Mar 2025

XYF19 CAR-T cell therapy (Xi'An Yufan Biotechnology)

Overview

Basic Info

Drug Type
Autologous CAR-T
Synonyms
CRISPR (HPK1) edited CD19specific CART cell therapyXiAn Yufan Biotechnology
+ [1]
Target
CD19 x HPK1
Action
inhibitors
Mechanism
CD19 inhibitors(B-lymphocyte antigen CD19 inhibitors), HPK1 inhibitors(Mitogen-activated protein kinase kinase kinase kinase 1 inhibitors)
Therapeutic Areas
NeoplasmsImmune System DiseasesHemic and Lymphatic Diseases
Active Indication-
Inactive Indication
B-Cell LymphomaCD19 Positive B-Cell LeukemiaCD19 Positive Lymphoma+ [1]
Originator Organization
Xi'an Yufan Biotechnologies Co., Ltd.Xi'an Yufan Biotechnologies Co., Ltd.Startup
Active Organization-
Inactive Organization
Xi'an Yufan Biotechnologies Co., Ltd.Xi'an Yufan Biotechnologies Co., Ltd.Startup
Drug Highest PhasePendingPhase 1
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with XYF19 CAR-T cell therapy (Xi'An Yufan Biotechnology)
NCT04037566
/ Unknown statusPhase 1IIT
A Safety Study of Autologous T Cells Engineered to Target CD19 and CRISPR Gene Edited to Eliminate Endogenous HPK1 (XYF19 CAR-T Cells) for Relapsed or Refractory Haematopoietic Malignancies.
100 Clinical Results associated with XYF19 CAR-T cell therapy (Xi'An Yufan Biotechnology)
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100 Translational Medicine associated with XYF19 CAR-T cell therapy (Xi'An Yufan Biotechnology)
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100 Patents (Medical) associated with XYF19 CAR-T cell therapy (Xi'An Yufan Biotechnology)
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100 Deals associated with XYF19 CAR-T cell therapy (Xi'An Yufan Biotechnology)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
B-Cell LymphomaPhase 1
China
Xi'an Yufan Biotechnologies Co., Ltd.Xi'an Yufan Biotechnologies Co., Ltd.Startup
01 Aug 2019
CD19 Positive B-Cell LeukemiaPhase 1
China
Xi'an Yufan Biotechnologies Co., Ltd.Xi'an Yufan Biotechnologies Co., Ltd.Startup
01 Aug 2019
CD19 Positive LymphomaPhase 1
China
Xi'an Yufan Biotechnologies Co., Ltd.Xi'an Yufan Biotechnologies Co., Ltd.Startup
01 Aug 2019
Refractory acute lymphoid leukemiaPhase 1
China
Xi'an Yufan Biotechnologies Co., Ltd.Xi'an Yufan Biotechnologies Co., Ltd.Startup
01 Aug 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NCT04037566 (ASCO2022)
ManualManual
Phase 1
Refractory B Acute Lymphoblastic Leukemia
11
(qyldbssgla) = gusjuxjkff hulvdhxubx (vutgaeopex )
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Positive
02 Jun 2022
Tecartus
(qyldbssgla) = hjlrklcpan hulvdhxubx (vutgaeopex )
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Approval

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Regulation

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