Drug Type Small molecule drug |
Synonyms Rolofylline (USAN), HMR-4902, KF-15372 + [3] |
Target |
Mechanism A1R agonists(Adenosine A1 receptor agonists) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 3 |
First Approval Date- |
Regulation- |
Molecular FormulaC20H28N4O2 |
InChIKeyPJBFVWGQFLYWCB-UHFFFAOYSA-N |
CAS Registry136199-02-5 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D08989 | Rolofylline | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Heart Failure | Phase 3 | - | 01 Aug 2007 | |
Acute decompensated heart failure | Phase 3 | - | 01 Aug 2006 | |
Acute decompensated heart failure | Phase 3 | - | 01 Aug 2006 | |
Hydrops Fetalis | Phase 3 | - | 01 Aug 2006 | |
Hydrops Fetalis | Phase 3 | - | 01 Aug 2006 | |
Hyperemia | Phase 3 | - | 01 Aug 2006 | |
Hyperemia | Phase 3 | - | 01 Aug 2006 | |
Volume overload | Phase 3 | - | 01 Aug 2006 | |
Volume overload | Phase 3 | - | 01 Aug 2006 | |
Kidney Diseases | Phase 2 | - | 01 Dec 2004 |
Phase 3 | - | (hjmugjiptm) = fnpkbkigba kcxfoydikk (smnutyuenz ) | Negative | 10 May 2011 | |||
Intravenous placebo | (hjmugjiptm) = rygsasnhtv kcxfoydikk (smnutyuenz ) | ||||||
Phase 2 | 59 | ccgxqlxxjl(elvxiayveu) = piyqtylveb humzxdufbc (monjhxjpvy ) View more | - | 01 Nov 2010 | |||
Phase 3 | 2,033 | ksyruwbltg(iqxcefvjml) = ccbopmaytb porpfxzzaw (ljhwhwvdss ) | Negative | 07 Oct 2010 | |||
Placebo | ksyruwbltg(iqxcefvjml) = kwvzyfyhks porpfxzzaw (ljhwhwvdss ) | ||||||
Phase 2 | 32 | qbsquojcvy(qpaopihnst) = jpsaeexsrh axpodvoqtb (uhwxboudjt ) | - | 01 Oct 2007 |