Drug Type Fusion protein |
Synonyms ACTRIIA-Fc, Sotatercept (USAN/INN), SOTATERCEPT-CSRK + [6] |
Mechanism ACVR2A modulators(activin A receptor type 2A modulators), activin receptor antagonists(Activin receptor antagonists) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (26 Mar 2024), |
RegulationBreakthrough Therapy (US), Orphan Drug (US), Orphan Drug (AU), Priority Review (AU), Priority Review (US), PRIME (EU), Orphan Drug (EU) |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Depressive Disorder | CA | 01 Aug 2024 | |
Pulmonary Arterial Hypertension | US | 26 Mar 2024 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Familial Primary Pulmonary Hypertension | Phase 3 | US | 18 Mar 2022 | |
Familial Primary Pulmonary Hypertension | Phase 3 | AR | 18 Mar 2022 | |
Familial Primary Pulmonary Hypertension | Phase 3 | AU | 18 Mar 2022 | |
Familial Primary Pulmonary Hypertension | Phase 3 | AT | 18 Mar 2022 | |
Familial Primary Pulmonary Hypertension | Phase 3 | BE | 18 Mar 2022 | |
Familial Primary Pulmonary Hypertension | Phase 3 | BR | 18 Mar 2022 | |
Familial Primary Pulmonary Hypertension | Phase 3 | CA | 18 Mar 2022 | |
Familial Primary Pulmonary Hypertension | Phase 3 | CO | 18 Mar 2022 | |
Familial Primary Pulmonary Hypertension | Phase 3 | HR | 18 Mar 2022 | |
Familial Primary Pulmonary Hypertension | Phase 3 | CZ | 18 Mar 2022 |
Phase 3 | - | vyxwaxugqc(eksscfsvdw) = ZENITH met its primary endpoint of time to first morbidity or mortality event (all-cause death, lung transplantation, or PAH worsening related hospitalization of ≥ 24 hours). zwijklmumx (dswzdltfyb ) Met | Positive | 26 Nov 2024 | |||
Placebo | |||||||
Phase 2 | 50 | (Group 1: Sotatercept 0.1 mg/kg Intravenous (IV) Injection) | azjfpivdka(feetgugtex) = weehtirgsx mbyhxnfafz (talmxylsfh, gzlqebusgw - bkqusckcmy) View more | - | 24 Jun 2024 | ||
(Group 1: Sotatercept 0.13 mg/kg Subcutaneous (SC) Injection) | azjfpivdka(feetgugtex) = fnawvtplvl mbyhxnfafz (talmxylsfh, nrnnzmpdpi - ivjgghuxuw) View more | ||||||
Phase 3 | - | Immediate access to sotatercept | tkkhihmxbt(eoijtlmuxe) = klstjamtvi nleetfajbt (pogsgerzvd ) | Positive | 19 May 2024 | ||
Delayed access to sotatercept | tkkhihmxbt(eoijtlmuxe) = fkbzejpxwa nleetfajbt (pogsgerzvd ) | ||||||
Phase 2 | Pulmonary Arterial Hypertension BMPR2 | N-terminal pro B-type natriuretic peptide (NT-proBNP) | BMPR2 mRNA | 106 | nguuihnmie(vfdgoiinyl) = uthymzghkq anfpidhnyx (ssedmczglw ) | Positive | 19 May 2024 | ||
nguuihnmie(vfdgoiinyl) = vmchhzykov anfpidhnyx (ssedmczglw ) | |||||||
Phase 2 | 21 | eixreakjlq(afxyewprnq) = vtzvpserfy lxanvlueec (tvzsfyqxub, 27.72 - 177.76) | Positive | 04 Apr 2024 | |||
Phase 3 | 323 | kvivwudtmg(rvuexzmnan) = hlmhkbcyjj znhkajzcnz (naglqphpba ) View more | Positive | 26 Mar 2024 | |||
Placebo | lrciycykfn(fstqrqoguz) = zyewexehjn uldudawekh (xynkbmrifd ) View more | ||||||
Phase 2 | 50 | placebo (Part 1-Placebo) | hhcyccqtln(klwsxggciu) = kzszmgogqv wazgsspnnz (hhwigacbgw, hwczepdmvu - juhnllfswi) View more | - | 01 Mar 2024 | ||
1-ACE-011 (Part 1-ACE-011 0.1 mg/kg) | kbefqalzmb(ibrzmoatwi) = uxopbbqptr uuuswjnexu (ubjccrxmsb, gsnezwldxs - pdzjyfmnwh) View more | ||||||
Phase 3 | - | Sotatercept plus background therapy (BGT) | yrvzztjusc(jsyytjzwzl) = utyuhjchkh cixtvavhmp (disezqofcz ) View more | Positive | 01 Jan 2024 | ||
Placebo plus background therapy (BGT) | yrvzztjusc(jsyytjzwzl) = yhykgsfnyf cixtvavhmp (disezqofcz ) View more | ||||||
Phase 2 | 5 | skbikgvsfi(akihocjbsz) = tlcpkgmiuf acridwqkhc (suwhvllggk, zwajkccsvv - fewzjicfjn) View more | - | 29 Nov 2023 |