Double-blind, placebo-controlled clinical study to analyze the efficacy of an organic pomegranate polyphenol complex supplementation on bone mineral density, bone turnover markers, inflammatory status, and antioxidant status in post-menopausal women

Start Date02 Sep 2022

Sponsor / Collaborator-

NCT02095145

/ CompletedPhase 2IIT

A Phase IIA Exploratory, Randomized, Placebo-Controlled Trial of Pomegranate Fruit Extract/Pomx™ in Subjects With Clinically Localized Prostate Cancer Undergoing Active Surveillance

This randomized phase II trial studies pomegranate-extract pill in preventing tumor growth in patients with prostate cancer that is limited to a certain part of the body (localized), who have chosen observation as their treatment plan. The use of pomegranate-extract pill may slow disease progression in patients with localized prostate cancer.

Start Date08 May 2014

Sponsor / Collaborator

National Cancer Institute

NCT02949583

/ CompletedNot ApplicableIIT

Clinical Effectiveness and Microbiological Evaluation of a Mouthwash of Pomegranate (Punica Granatum Linn.) in School Children

The mechanical control of supragingival biofilm is accepted as one of the most important measures to prevent dental caries and periodontal diseases. Nevertheless, maintaining dental surfaces biofilm-free is not an easy task. In this regard, numerous studies researches have demonstrated the effectiveness of mouthwashes containing antimicrobial active ingredients that prevent and control both supragingival biofilm and gingivitis, specially when used adjunctively to mechanical oral hygiene regimens.

Start Date01 Mar 2012

Sponsor / Collaborator

Universidade Estadual Da Paraíba

100 Clinical Results associated with Pomegranate Extract

100 Translational Medicine associated with Pomegranate Extract

100 Patents (Medical) associated with Pomegranate Extract

439

Literatures (Medical) associated with Pomegranate Extract

01 Jun 2025·PROSTAGLANDINS & OTHER LIPID MEDIATORS

An updated systematic review and meta-analysis of pomegranate consumption on lipid profile

Review

Author: Cheng, Wengong ; Huang, Aiqiong ; Liang, Kaiqin

Pomegranate, rich in bioactive compounds such as polyphenols and flavonoids, has been studied for its potential lipid-modulating effects, yet evidence remains inconsistent. This systematic review and meta-analysis aimed to evaluate the impact of pomegranate consumption on plasma lipid profiles by synthesizing data from randomized controlled trials (RCTs). Following PRISMA guidelines, 37 RCTs (n = 2695 participants) were included after searching Scopus and MEDLINE databases. Studies assessed pomegranate products (juice, extract, seed oil) administered orally for ≥ 7 days, with lipid parameters, including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) as outcomes. Data were pooled using RevMan 5.3 with random-effects models. Results indicated that pomegranate intake significantly increased HDL-C levels (mean difference: 2.50 mg/dL, 95 % CI: 1.00-4.00, p < 0.05), while no significant changes were observed in TC, LDL-C, or TG. Subgroup analyses revealed pronounced HDL-C elevation in non-alcoholic fatty liver disease (NAFLD) patients, health participants and interventions lasting ≥ 8 weeks. Heterogeneity across studies was attributed to variations in intervention duration, dosage forms, and participant characteristics. Publication bias was nonsignificant (Egger's test, p > 0.05). These findings suggest that pomegranate supplementation may improve HDL-C, potentially through modulation of HDL-associated enzymes like paraoxonase. However, further large-scale, long-term RCTs are warranted to confirm these effects and explore synergistic benefits with standard lipid-lowering therapies.

01 Jun 2025·Data in Brief

Dataset creation of thermal images of pomegranate for internal defect detection

Article

Author: Gaikwad, Ashvini ; Deshpande, Manoj ; Bhole, Varsha

Datasets are crucial in various fields, especially in the context of machine learning, data science and research. Datasets are used to train machine learning models. A model learns patterns and relationships from the data it is exposed to. The dataset used for training a machine learning model shall be diversified and consist sufficient samples of desired categories. This paper presents various steps and its outcome in preparing the dataset of digital and thermal images of pomegranate for recognising internal defects. The defects in fruits are often categorised as surface defects and internal defects. The surface defects are recognised with digital RGB image but fails to give insight about the internal structure of the fruit in which we are often interested. The thermal images can be used to detect the internal defects in fruits. When a fruit is subjected to temperature difference as compared to the surrounding, the thermal emissions from fruit captured through a thermal camera (thermal image) gives the key information about the internal damages in the fruit. The internal defects are reflected in thermal image as variations in temperature of adjacent pixels. The k-mean segmentation is applied for identifying internal defects with thermal images in pomegranates to categorize them viz. No defect, major defect and minor defect. This information is useful for training a machine learning algorithms that are intended for bulk processing in the field of fruit defect detection and classification.

01 Apr 2025·Clinical Nutrition ESPEN

Pomegranate juice ameliorates craving and oxidative stress on patients under medication for opioid addiction treatment with methadone and buprenorphine: A ranzomised controlled trial

Article

Author: Metsios, George S ; Leventelis, Christonikos ; Papageorgiou, Kalliopi ; Tentolouri, Anna ; Barmpas, Petros T ; Kouretas, Demetrios ; Tekos, Fotios ; Ververi, Anastasia ; Makri, Sotiria ; Veskoukis, Aristidis S ; Mountzouridi, Evangelia ; Tasoulis, Sotiris

BACKGROUND & AIMS:

Buprenorphine and methadone are drugs used as medication for addiction treatment for patients with opioid use disorders (OUDs). However, scarce evidence indicates that they induce oxidative stress, which contributes to the deterioration of psychosocial parameters, thus complicating successful rehab. Therefore, a dietary antioxidant intervention such as pomegranate could be beneficial for that group of patients. Therefore, the aim of this study, whose protocol has been registered in the international database ClinicalTrials.gov (Identifier: NCT05861544), was to examine the putative beneficial role of consumption of natural pomegranate juice that possesses potent antioxidant properties on craving, a psychosocial parameter of utmost importance, and blood redox status of patients with OUDs.

METHODS:

The juice was administered at the following dosage: 250 ml/day, 7 days/week, 120 days. The heroine craving questionnaire was completed to assess craving and blood was collected by the volunteers at three time points, namely days 1, 60 and 120 and well-established redox biomarkers were measured in blood.

RESULTS:

Overall, craving of all patients was improved due to the nutritional treatment applied. Moreover, their blood antioxidant potential was enhanced due to pomegranate juice consumption.

CONCLUSIONS:

As a conclusion, the obtained evidence is promising, thus, it appears that pomegranate juice consumption could be considered as an auxiliary nutritional intervention in parallel with medication towards rehab of opioid-addicted patients.

News (Medical) associated with Pomegranate Extract

28 Dec 2023

·www.prnewswire.com

3 Tips to Combat Dry Skin in Winter, including Essential Skin Food From ActivatedYou By Maggie Q

A Skin Nourishing Collagen Support Complex For a Clear, Hydrated, and Healthy-looking Complexion LOS ANGELES, Dec. 28, 2023 /PRNewswire/ -- With winter here, the drop in temperature often brings along a common problem: dry, dehydrated skin. The cold air outside, combined with the warm, dry air indoors, can strip the skin of its natural moisture, leaving it feeling dry, itchy, and patchy. Actor and wellness advocate Maggie Q recognizes the challenges that winter poses to our skin and shares these tips to help combat this seasonal skin struggle. Continue Reading ActivatedYou Essential Skin Food is a skin-nourishing collagen support complex designed to deliver smooth, tight, and youthful-looking skin regardless of age or season, making it particularly beneficial during winter. This dietary supplement operates internally, promoting healthy collagen production—the essential foundation of your skin. Hydrate from Within: As soon as you wake up, drink at least a full glass of water to start your day off hydrated. Hydration comes from the inside, and maintaining a good water intake helps your skin stay moisturized. Herbal teas and water-rich foods, like fruits and vegetables, can also contribute to your overall hydration. Use a Humidifier: Combat the dry indoor air by incorporating a humidifier into your living or working space. Central heating systems tend to sap the moisture from the air, leading to drier skin. A humidifier helps maintain the humidity levels, preventing your skin from becoming excessively dry. Take a Daily Skin Health Supplement: Skin health supplements such as ActivatedYou Essential Skin Food® are designed to support healthy collagen production, the key to firmer and plumper-looking skin. This formulation is crafted with six plant-based skin-nourishing compounds that work synergistically to support the production of collagen – the fundamental building blocks of the skin. These compounds not only aid in collagen synthesis but also combat skin-damaging free radicals, helping to promote a clear, hydrated, and healthy-looking complexion.†* What is ActivatedYou Essential Skin Food?†* ActivatedYou Essential Skin Food is a skin-nourishing collagen support complex designed to deliver smooth, tight, and youthful-looking skin regardless of age or season, making it particularly beneficial during winter. This dietary supplement operates internally, promoting healthy collagen production—the essential foundation of your skin. Crafted with six plant-based skin-nourishing compounds, each ingredient helps facilitate healthy cell turnover, combat elastin breakdown that causes the appearance of sagging skin, and fight skin-damaging free radicals. The result is a clear, hydrated, and healthy complexion, ideal for combating the harsh effects of winter weather. Unlike conventional collagen supplements, ActivatedYou Essential Skin Food distinguishes itself as a natural collagen builder without any animal-based collagen. Completely derived from plant-based ingredients, it actively supports the natural growth of collagen within your body. This winter, fortify your skin from head to toe with an innovative approach to skincare that enhances your skin's resilience and radiance. ActivatedYou Essential Skin Food Key Ingredients† Vitamin C: a natural antioxidant that promotes a more radiant and bright complexion, contributing to healthier-looking skin by fending off free radicals that can harm the skin.* Amino Acid Complex: a combination of Lysine and L-Proline, essential building blocks of collagen. These components work in harmony to help tighten and enhance the look of skin's plumpness over time.* Dermaval™: a natural collagen booster that harnesses the power of phytonutrient compounds like pomegranate extract, camu camu, coffeeberry, and quercetin to combat the breakdown of elastin in the body, supporting skin elasticity and firmness.* Cosmythic™: an elixir infused with polyphenols that help support collagen production for more youthful-looking skin.* Where to Purchase ActivatedYou Essential Skin Food ActivatedYou Essential Skin Food can be purchased on the ActivatedYou website for $69.95 with a 90-day money-back guarantee. About Maggie Q As a health advocate, animal rights activist, founder of fitness apparel brand Qeep Up, ActivatedYou founder, and actor—best known for her roles in Nikita, Designated Survivor, and Mission: Impossible III, Maggie Q uses her name to advocate for those in need. Maggie's personal health struggles led her to do extensive research in the world of nutrition and inspired her to create her own line of wellness supplements, ActivatedYou. Follow @maggieq on Instagram. About ActivatedYou ActivatedYou was founded by health advocate, animal rights activist, and actor Maggie Q, with Dr. Frank Lipman, a renowned gut-health expert and a pioneer of integrative medicine. ActivatedYou's unique formulas blend the latest in cutting-edge health and nutrition with age-old Eastern traditions and healthy ingredients for unique, effective formulas designed to help revolutionize health and improve lives. ActivatedYou's best-selling products include Advanced Restorative Probiotic, AdrenaLife, and Active Enzyme. To learn more about Maggie Q's ActivatedYou line, visit and follow @activatedyou on Instagram, @ActivatedYou on Twitter, and ActivatedYou on YouTube. *All individuals are unique. Your results can and will vary. Press Contact: Laura Baumgartner - Asylum PR [email protected] SOURCE ActivatedYou

11 Dec 2023

·www.prnewswire.com

A Delicious Way to Support Your Immune System

MISSION, Kan., Dec. 11, 2023 /PRNewswire/ -- (Family Features) Bolstering your immune system during winter, when coughs and colds seem to take control, is a must for the entire family. Supporting your wellness can start in a simple place – with the foods you eat and drink. Continue Reading Orange Juice and Coconut Chickpea Soup Superfruit Breakfast Smoothie Consider an easy choice for any season like Florida Orange Juice, which can help you and your loved ones get the vitamins and minerals you need all winter long. With 100% of the daily recommended value of vitamin C in every 8-ounce serving along with key nutrients like potassium and magnesium, there's a reason it's referred to as the "Original Wellness Drink." With no added sugar or artificial flavor, it provides the benefits you need without the additives you don't. It contains natural sugar from the whole fruit for a delicious solution that's one of nature's nutrient-rich foods with vitamins, minerals and phytonutrients. Plus, it's easy to use as a nutritional ingredient in wintertime favorites like this comforting Orange Juice and Coconut Chickpea Soup or to start your day strong with a Superfruit Breakfast Smoothie. Paired with a healthy lifestyle, 8 ounces of 100% orange juice may help support a healthy immune system as an excellent source of vitamin C and a good source of vitamin D in fortified juices. Vitamin C is commonly associated with helping maintain and strengthen healthy immune systems by protecting cells and promoting the production and function of immune cells. Meanwhile, vitamin D also plays an important role in regulating immune response by helping immune cells fight off bacteria and viruses. "Safeguarding your health against the spread of illness is important year-round, especially during colder months when reports of cold and flu increase," said Dr. Rosa Walsh, director of scientific research at the Florida Department of Citrus. "A key step in supporting your immune system is maintaining a well-balanced diet that is high in essential nutrients. Incorporating an 8-ounce glass of 100% orange juice can help you meet the recommended daily value of vitamin C and support your hydration." Beneficial plant compounds, like those in Florida Orange Juice, along with flavonoids and colorful carotenoids work to support the immune system by fighting inflammation and helping cells communicate, which can help strengthen immune responses when encountering infections. Additionally, 100% orange juice is a source of phytonutrients like hesperidin, which has been shown in clinical studies to have antioxidant-like properties, heart health benefits and may help reduce inflammation. Hesperidin has also been linked with benefits related to cognitive function, immune system function and bone health. To find more information and immunity-boosting winter recipes, visit FloridaJuice.com. Orange Juice and Coconut Chickpea Soup Servings: 8 1 tablespoon olive oil 1 cup diced yellow onion 1 red bell pepper, diced 1 1/2 cups diced carrots 1 1/2 teaspoons kosher salt 3 cloves garlic, finely grated 1/2 teaspoon ground cardamom 1 quart vegetable broth 1 can (14 ounces) light coconut milk 1 can (14 ounces) chickpeas, drained and rinsed 1/2 cup Florida Orange juice chopped cilantro (optional) In medium saucepan over medium high, heat olive oil until it shimmers. Add onions, bell pepper, carrots and salt; cook until onions are translucent, 5-7 minutes. Add garlic and cardamom; cook 1-2 minutes, or until garlic is fragrant. Do not brown. Add vegetable broth, coconut milk and chickpeas; bring to simmer. Decrease heat to low and cook until carrots are tender, about 10 minutes. Add orange juice, remove from heat and stir. Taste and adjust seasoning as desired. Serve garnished with cilantro, if desired. Superfruit Breakfast Smoothie Servings: 2 8 ounces Florida Orange Juice 4 ounces dark sweet cherries 2 ounces pomegranate juice In blender, puree orange juice, cherries and pomegranate juice then serve. Michael French [email protected] 1-888-824-3337 editors.familyfeatures.com About Family Features Editorial Syndicate A leading source for high-quality food, lifestyle and home and garden content, Family Features provides readers with topically and seasonally relevant tips, takeaways, information, recipes, videos, infographics and more. Find additional articles and information at Culinary.net and eLivingToday.com. SOURCE Family Features Editorial Syndicate

30 Nov 2023

·www.prnewswire.com

Astral Tequila and The Sculpt Society Unite to Launch the 'Good Energy Movement' Nationwide

Created in collaboration with fitness trainer and Founder of The Sculpt Society, Megan Roup, the two brands are brightening the holiday season and ushering in the New Year through the power of movement and connection. NEW YORK, Nov. 30, 2023 /PRNewswire/ -- As we enter the holiday season and prepare to welcome the New Year, Astral Tequila and The Sculpt Society are joining forces to ignite a 'Good Energy Movement.' It's proven important to embrace a positive mindset in the winter months, according to a study by the International Journal of Wellbeing1, and with the days getting shorter and the weather turning colder, it's a vital time to foster connections, continue to uplift one another, and keep the good energy circulating well into 2024. Continue Reading Astral Tequila and The Sculpt Society unite to launch the ‘Good Energy Movement’ nationwide, harnessing and spreading the power of positive energy through movement and connection. Experience the full interactive Multichannel News Release here: Created in partnership with fitness trainer and The Sculpt Society Founder, Megan Roup, the 'Good Energy Movement' offers a variety of virtual and in-person experiences to make spreading good energy more accessible. Participants wanting to get into a positive mindset can join in with 'Good Energy Movement' workouts, Astral Tequila get-togethers organized for moments of connection, and an exclusive holiday cocktail kit that serves as the perfect gift that gives back. Through these elements, the 'Good Energy Movement' aims to harness and spread the power of positive energy to your inner circle and beyond. "At Astral Tequila, spreading good energy is at the heart of everything we do, from harnessing the energy of the sun to grow our agave, to upcycling our spent agave fibers into adobe bricks used to build homes for people in Mexico," says Christina Choi, Senior Vice President of Tequila, Diageo North America. "With The Sculpt Society, we've found a like-minded partner who shares our passion for spreading positivity and connection." The series of 'Good Energy Movement' in-person sessions featuring workouts and post-workout Astral Tequila get-togethers are available exclusively through The Sculpt Society App and popping up in Dallas, Texas, and Charleston, South Carolina. If you're participating virtually from home, you can treat yourself and your loved ones (must be 21+) to a limited-edition 'Good Energy Movement' kit, featuring Megan's picks for creating a good energy oasis for you and your inner circle. In the spirit of giving back, the kit includes a one-month subscription to The Sculpt Society for you and one to gift a friend, a limited-edition co-branded exercise ball, ideal for your 'Good Energy Movement' workouts, and all the ingredients needed to make Megan's Mistletoe Margarita, featuring a winter twist on the classic cocktail. The kit is available starting today through December 30th for consumers 21+ on Cocktailcourier.com/product/astral-x-tss for an SRP of $69.99 while supplies last. "The 'Good Energy Movement' is all about coming together and sharing positive energy, and I'm thrilled to partner with Astral Tequila to make this happen," said Megan Roup, Founder of The Sculpt Society. "Through movement, connection, and some fantastic cocktails, we aim to bring people together during this time of year." Check out Astral Tequila and The Sculpt Society's Instagram pages for updates all season long and become part of the 'Good Energy Movement.' And as you do, please remember to enjoy Astral Tequila responsibly. Make Megan's favorite Astral Tequila recipe at home! Mistletoe Margarita 1.5oz Astral Tequila Blanco 0.75oz Lime Juice 0.75oz Pomegranate Juice 0.5oz Agave Garnish: Toasted Rosemary Instructions: Combine all ingredients in a cocktail shaker, add ice, shake and strain into an ice-filled rocks glass. Garnish with a sprig of toasted rosemary. About Astral Tequila Astral Tequila is a super-premium tequila crafted using 100% Blue Weber agave nourished by the sun and stars in Jalisco, Mexico. Using a tahona and bagazo during fermentation, Astral Tequila's unique recipe uses traditional, time-intensive processes to create a radiant tequila that brightens every cocktail. Each bottle of Astral Tequila produced helps continue the circular flow of good energy – leftover agave fibers are upcycled into adobe bricks to be used to construct buildings in local communities in Mexico to create more places to gather with loved ones and feel connected. Astral Tequila launched in April 2021 with its first expression, Blanco, followed by Reposado and Añejo in April 2023. For more information on Astral Tequila, please visit . About The Sculpt Society The Sculpt Society is the #1 Sculpt and Dance Cardio workout designed to empower women through movement. Created by celebrity trainer Megan Roup, The Sculpt Society app offers fun and effective low-impact sculpt workouts to tone your entire body, easy-to-follow dance cardio classes + yoga, stretch and meditation videos. With 600+ on-demand workouts, weekly live classes and guided programs, The Sculpt Society's results-driven fitness method will help you see and feel the difference. 1 Journal of Wellbeing Study SOURCE Diageo North America

100 Deals associated with Pomegranate Extract

R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Localized Prostate Carcinoma	Phase 2	United States	National Cancer Institute	08 May 2014
Salivary Gland Adenoma, Pleomorphic	Phase 2	United States	National Cancer Institute	08 May 2014
Erectile Dysfunction	Phase 2	United States	POM Wonderful LLC	01 Aug 2011

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02095145 (CTgov)	Phase 2	Salivary Gland Adenoma, Pleomorphic \| Localized Prostate Carcinoma	38	Pharmacological Study+Pomegranate-Extract Pill (Group I (Pomegranate-extract Pill))	lduoiffgpe(qzxzjleggu) = fcydhezydh owpahhkehl (tgyiufyfqi, 21.22) View more	-	05 Feb 2020
				Placebo (Group II (Placebo))	lduoiffgpe(qzxzjleggu) = ppknvhuqfw owpahhkehl (tgyiufyfqi, 23.11) View more
NCT01102140 (ImPrOVE, CTgov)	Phase 2	Cardiomyopathies \| Renal Insufficiency \| Heart Failure ... View more	20	POMx, pomegranate polyphenol extract (POMx)	apmtzwwhqq(udisbzanlb) = qzaywjuegg sbofohvvpx (mwvhalimxn, ygkhgyobsx - dyjnsjtwmm) View more	-	14 Jul 2017
				sugar pill (Control- Sugar Pill)	apmtzwwhqq(udisbzanlb) = leokmrdmas sbofohvvpx (mwvhalimxn, rkkfbniaoz - vympcayzvv) View more
Pubmed \| Atherosclerosis	Not Applicable	Hypercholesterolemia LDL-cholesterol \| thiols concentration \| reactive oxygen species (ROS) ... View more	23	Simvastatin + Vegan Placebo Pill	qqcygtlgwb(dpzcgybqzm) = wgetqllcfk mistqkaarv (uhaqpnojwb )	Positive	01 Jan 2014
				Simvastatin + POMx Pill	ubkeizvqig(bloiirppye) = spjgdwkwhb awzoxuljdj (usspwbmadb )

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