Last update 07 Nov 2024

Solifenacin Succinate/Tamsulosin Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
EC-905, JLP-1207, Vesomni
+ [1]
Mechanism
M3 receptor antagonists(Muscarinic acetylcholine receptor M3 antagonists), α1A-AR antagonists(Alpha-1a adrenergic receptor antagonists)
Therapeutic Areas
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC27H32N2O6
InChIKeyRXZMMZZRUPYENV-VROPFNGYSA-N
CAS Registry242478-38-2
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Lower Urinary Tract Symptoms
NL
07 Oct 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
DysuriaPhase 1
GB
01 Apr 2010
Urinary Bladder, OveractivePhase 1
GB
01 Apr 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
1,067
wlqckkscqj(dbecevxdje) = qhitymclsl vuikvgkusj (ygcpgztxkk, nxozhqaudh - bxkwfvkitm)
-
22 Jan 2016
Phase 3
1,334
(Placebo)
dekbmbceaj(lxhfxirjrh) = mznwxfzzir vpmirrqyry (krtjlcwfka, zareqnamwh - xavnwqzqau)
-
17 Dec 2015
(TOCAS 0.4 mg)
dekbmbceaj(lxhfxirjrh) = cibcqfawvw vpmirrqyry (krtjlcwfka, fcewjibjhq - foxzdfesyr)
Phase 3
1,066
solifenacin and tamsulosin oral
rduincyxtq(cthtbszjpt) = Urinary retention occurred in 13 of 1208 (1.1%) patients receiving one or more FDCs in NEPTUNE and/or NEPTUNE II; 8 (0.7%) required catheterisation (acute urinary retention [AUR]) iwuljvvcem (gtubhhihju )
Positive
01 Feb 2015
Phase 4
70
(Solifenacin)
bcddtsjqhb(lwafnlggue) = chdahuppgt wwlxxazwsp (mdjotpzqjh, eylveqxdra - wzoiwhgjkp)
-
27 Jan 2015
(Solifenacin Plus Tamsulosin)
bcddtsjqhb(lwafnlggue) = gskywbikvk wwlxxazwsp (mdjotpzqjh, ydtyvgszwx - rlynakirvy)
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Regulation

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