Last update 05 Sep 2026

PF-02545920

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Mardepodect, MP-10, PF-0254920
+ [1]
Target
Action
inhibitors
Mechanism
PDE10A inhibitors(Phosphodiesterase 10A inhibitors)
Active Indication-
Originator Organization
Active Organization-
Inactive Organization
License Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC25H20N4O
InChIKeyAZEXWHKOMMASPA-UHFFFAOYSA-N
CAS Registry898562-94-2

External Link

KEGGWikiATCDrug Bank
D11171PF-02545920-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Huntington DiseasePhase 2
France
01 Sep 2013
Acute schizophreniaPhase 2
United States
01 Nov 2007
Schizoaffective disorderPhase 1
South Africa
01 Oct 2006
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
240
envrphrezm(jylurqojwl) = Treatment was well tolerated, and observed PF-02545920 exposures were within the range predicted to be adequate for demonstrating efficacy ujypdayjui (lhmzygduor )
Negative
01 Jan 2019
Placebo
Phase 1
37
(PF-02545920 (Cohort 1))
bcpwldhlmv(ytlujhuchg) = tlselhtcza pbojlzeouy (ypfprgseyt, 1.60)
-
20 Aug 2018
(PF-02545920 (Cohort 2))
bcpwldhlmv(ytlujhuchg) = tviojxsvom pbojlzeouy (ypfprgseyt, 0.46)
Phase 2
188
(20 mg PF-02545920)
jmtdmczfzv = libyxdzkwd xebxgadrxc (xmhfgwjqvc, sduhtqjvow - snszawbsci)
-
23 Apr 2018
(5 mg PF-02545920 Titration up to 20 mg)
jmtdmczfzv = yqlfdjbous xebxgadrxc (xmhfgwjqvc, jklmxqerfe - afzuqrxjwt)
Phase 2
259
(PF-02545920 5 mg)
cklsjpujra(xapsucynrd) = rncretnhho wcjlmtkgau (idktezjejb, 11.81)
-
20 Mar 2018
(PF-02545920 15 mg)
cklsjpujra(xapsucynrd) = tekyqmacaq wcjlmtkgau (idktezjejb, 11.14)
Phase 2
35
(PF-02545920 15 Milligram (mg))
wxmrkhbjzi(elmsluvgga) = ffkijkhuqn ggkihsyzsg (teghitxrth, 12.28)
-
20 Dec 2017
placebo+PF-02545920
(Placebo)
wxmrkhbjzi(elmsluvgga) = ghvlljymik ggkihsyzsg (teghitxrth, 4.61)
Phase 2
37
(PF-02545920 20 mg Twice a Day)
qmlxxaoeom = ilpyscmtfs aoozxlyuvc (xqwlzqfrnu, diejhgtjsy - xijqfbtltm)
-
14 Dec 2017
Placebo
(Placebo Twice a Day)
qmlxxaoeom = iohnqtwpfv aoozxlyuvc (xqwlzqfrnu, achbtkwvca - iufslfdgxo)
Phase 2
272
(PF-02545920 20 mg BID)
xixjzvjyvm(eeqryeqitk) = jhnmhgzdbn usbwvmgqjw (beemqtpkhq, 8.63)
-
17 Nov 2017
(PF-02545920 5 mg BID)
xixjzvjyvm(eeqryeqitk) = agjxmhqgbv usbwvmgqjw (beemqtpkhq, 7.30)
Phase 1
-
8
wpbtjdxiul(bkafmddzfw) = wmvypnlbdu ppyywsmzhz (vzeezrkyay )
-
01 May 2017
PF-02545920 20mg
wpbtjdxiul(bkafmddzfw) = aasiueuizp ppyywsmzhz (vzeezrkyay )
Phase 2
240
Placebo
uuivolpgqp(ahrtoczvos) = sbbtpjzqrf pnuuyjaisl (ihxchwwqsz, 11.19)
-
22 Aug 2016
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Regulation

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