Last update 30 Nov 2024
PF-6263276
Last update 30 Nov 2024
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms PF 6263276, PF-06263276 |
Target |
Mechanism JAK inhibitors(Janus kinase inhibitors) |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePreclinical |
First Approval Date- |
Regulation- |
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Structure
Molecular FormulaC31H31FN8O2 |
InChIKeyXDJGNPSZQSWJCV-UHFFFAOYSA-N |
CAS Registry1421502-62-6 |
Related
2
Clinical Trials associated with PF-6263276A Phase 1, Single- Center, Randomized, Double-blind, Vehicle And Active Comparator-controlled Trial To Evaluate The Antipsoriatic Activity And Safety Of A Topically Applied Pf-06263276 Formulation In A Psoriasis Plaque Test
A Phase 1, Randomized, Third-Party Open, Placebo-Controlled, Multiple Dose Escalation, Parallel Group Study To Evaluate Local Tolerability, Safety And Pharmacokinetics Of Topically Applied PF-06263276 In Healthy Subjects
100 Clinical Results associated with PF-6263276
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100 Translational Medicine associated with PF-6263276
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100 Patents (Medical) associated with PF-6263276
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1
Literatures (Medical) associated with PF-626327626 Jan 2017Journal of medicinal chemistryQ1 · MEDICINE
Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin
Q1 · MEDICINE
Article
Author: Coe, Jotham W. ; Chrencik, Jill E. ; Kortum, Steve W. ; Mukaiyama, Takasuke ; Sabnis, Yogesh A. ; England, Katherine S. ; Yeoh, Thean ; Brown, David G. ; Whitlock, Gavin A. ; Morgan, Paul ; Storer, R. Ian ; Dehnhardt, Christoph M. ; Wakenhut, Florian M. ; Murphy, John R. ; Jones, Peter ; Jones, Rhys M. ; Kilty, Iain
By use of a structure-based computational method for identification of structurally novel Janus kinase (JAK) inhibitors predicted to bind beyond the ATP binding site, a potent series of indazoles was identified as selective pan-JAK inhibitors with a type 1.5 binding mode. Optimization of the series for potency and increased duration of action commensurate with inhaled or topical delivery resulted in potent pan-JAK inhibitor 2 (PF-06263276), which was advanced into clinical studies.
100 Deals associated with PF-6263276
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Psoriasis vulgaris | Phase 1 | DE | 01 Sep 2014 | |
| Plaque psoriasis | Phase 1 | BE | 01 Nov 2013 | |
| Dermatitis | Preclinical | US | 04 Jan 2017 | |
| Pneumonia | Preclinical | US | 04 Jan 2017 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
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Phase 1 | 15 | (PF-06263276 4% Solution) | owktfsopec(ncsyennsme) = lgqiyrbjwi hkhzdctsjq (vkegvsfnqc, iaetxxgauq - olqxbucvka) View more | - | 09 Jun 2016 | ||
(PF-06263276 Vehicle) | owktfsopec(ncsyennsme) = nntojqggii hkhzdctsjq (vkegvsfnqc, ieikpnbesq - wetcdnwkel) View more |
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