Double-blind Randomized Placebo Controlled Study on the Effect of Enoxolone ( 11-beta Hydroxysteroid-dehydrogenase Type 2 Inhibitor) on the RAAS, Autonomic and Imaging Biomarkers and the Outcome of Depression

Many different forms of depression exist. It is difficult to predict to what treatment a given patient with depression responds. Studies demonstrate that biomarkers can help to distinguish different forms of depression. Simple markers, like aldosterone/cortisol in body fluids, blood pressure and inflammation markers , have been identified as predictors of therapy resistance in depression. Enoxolone is a molecule derived from the licorice plant and has demonstrated an effect on these biomarkers, which may imply an improved response. The current randomized placebo controlled study is assessing whether the presence of markers of therapy resistance can predict a preferential effect of enoxolone vs. placebo on clinical outcome. Secondarily, it is tested whether these markers change differentially in the treatment groups. Finally, the relationship between the change of the markers and clinical change will be assessed.

Start Date23 Sep 2022

Sponsor / Collaborator

Philipps University Marburg Medical Center

[+1]

NCT05555004 / TerminatedNot Applicable

Evaluation of Probiotic (L.Reuteri) Survival in Presence of Prebiotic Galacto-oligosaccharides

This research study will compare the effect of test product #1 (containing a probiotic with the Galacto-OligoSaccharides fiber. GOS) and test product #2 (containing a probiotic without the GOS fiber) to understand how they can contribute to healthy digestion in toddlers between the age of 24 - 36 months. The hypothesis is that L. reuteri from TEST#1 will demonstrate an improved survival in the GIT of toddlers compared to that of TEST#2.
This study is a single-centre, randomized, double-blind, comparator-controlled, parallel group study. The study will be conducted at the Clinical Innovation Lab (CIL) at Nestlé Research.

Start Date30 Jun 2022

Sponsor / Collaborator

Société des Produits Nestlé SA

100 Clinical Results associated with Glycyrrhetinic Acid

100 Translational Medicine associated with Glycyrrhetinic Acid

100 Patents (Medical) associated with Glycyrrhetinic Acid

1,614

Literatures (Medical) associated with Glycyrrhetinic Acid

01 Jan 2025·COLLOIDS AND SURFACES B-BIOINTERFACES

Glycyrrhizic acid and glycyrrhetinic acid loaded cyclodextrin MOFs with enhanced antibacterial and anti-inflammatory effects for accelerating diabetic wound healing

Article

Author: Khan, Md. Zaved H. ; Ma, Fanyi ; Zhan, Mengke ; Lei, Lijing ; Zhu, Jinhua ; Khan, Md Zaved H ; Liu, Xiuhua ; Zhou, Danyang

A water stable cyclodextrin MOF (Cu-SD) was synthesized with γ-cyclodextrin derivative as organic ligand and Cu²⁺ as metal center to co-crystallizely load glycyrrhizic acid (GL) and glycyrrhetinic acid (GA). Cu-SD has a high drug loading capacity for GL (499.91 μg/mg) and GA (112.37 μg/mg), and the drug-loaded materials had a controlled release in different meadiums. In addition, Cu-SD and its drug loaded materials demonstrated better inhibiting α-glucosidase activity than the control drug acarbose. Furthermore, Cu-SD presented excellent antibacterial activity, and the antibacterial activity was significantly enhanced after GA and GL being encapsulated by Cu-SD. Moreover, both free and drug-loaded materials had good anti-inflammatory activities, and the anti-inflammatory effects of GL@Cu-SD and GA@Cu-SD were superior to those of their corresponding free drugs. Cu-SD, GL@Cu-SD and GA@Cu-SD demonstrated good biocompatibility and were applied to treat the wounds of diabetic rats. The experimental results showed that GL@Cu-SD and GA@Cu-SD had good promoting effects on the recovery of chronic diabetic wounds by suppressing wound inflammation.

01 Jan 2025·COLLOIDS AND SURFACES B-BIOINTERFACES

Novel targeting liposomes with enhanced endosomal escape for co-delivery of doxorubicin and curcumin

Article

Author: Wu, Wenlan ; Zhang, Mengyi ; Liang, Ju ; Liang, Ying ; Yan, Fuqing

Effective endosomal escape is crucial for enhancing the efficiency of nanodrug delivery systems. In this study, we developed a novel liposomal system utilizing acid-sensitive N-(3-amino-propyl) imidazole cholesterol (IM-Chol), specifically designed for the targeted co-delivery of doxorubicin (DOX) and curcumin (CUR) to hepatocellular carcinoma (HCC). Designated as GA-IM-LIP@DOX/CUR, this liposomal system incorporates glycyrrhetinic acid (GA) to improve target specificity toward HCC cells. Notably, both drugs exhibited pH-sensitive release profiles, facilitating precise drug release within acidic environments. Our investigation into cellular uptake demonstrated that modified liposomes, GA-IM-LIP@FITC and IM-LIP@FITC, achieved progressively enhanced intracellular accumulation of FITC compared to unmodified liposomes. Competitive inhibition assays utilizing free GA further validated the targeting efficacy of GA. Moreover, the GA-IM-LIP@FITC and IM-LIP@FITC groups exhibited rapid endosomal escape of FITC within the first two hours, in contrast to delayed escape observed in the LIP@FITC group, confirming that the protonation of IM-Chol promotes drug release into the cytosol. In vivo studies substantiated that GA-IM-LIP@DOX/CUR effectively inhibited tumor growth. This research provides significant insights into the design and functionality of the GA-IM-LIP@DOX/CUR liposomal system, underscoring its potential to enhance drug delivery strategies in the treatment of HCC.

01 Nov 2024·Infectious disorders drug targets

Insight into the Natural Biomolecules (BMs): Promising Candidates as Zika Virus Inhibitors

Review

Author: Semwal, Amit ; Garg, Ruchika ; Dobhal, Kiran ; Singh, Alka

Abstract::

Zika virus (ZIKV) is among the relatively new infectious disease threats that include SARS-CoV2, coronavirus, monkeypox (Mpox) virus, etc. ZIKV has been reported to cause severe health risks to the fetus. To date, satisfactory treatment is still not available for the treatment of ZIKV infection. This review examines the last five years of work using natural biomolecules (BMs) to counteract the ZIKV through virtual screening and in vitro investigations. Virtual screening has identified doramectin, pinocembrin, hesperidins, epigallocatechin gallate, pedalitin, and quercetin as potentially active versus ZIKV infection. In vitro, testing has shown that nordihydroguaiaretic acid, mefloquine, isoquercitrin, glycyrrhetinic acid, patentiflorin-A, rottlerin, and harringtonine can reduce ZIKV infections in cell lines. However, in vivo, testing is limited, fortunately, emetine, rottlerin, patentiflorin-A, and lycorine have shown in vivo anti- ZIKV potential. This review focuses on natural biomolecules that show a particularly high selective index (>10). There is limited in vivo and clinical trial data for natural BMs, which needs to be an active area of investigation. This review aims to compile the known reference data and discuss the barriers associated with discovering and using natural BM agents to control ZIKV infection.

News (Medical) associated with Glycyrrhetinic Acid

25 Oct 2022

·www.biospace.com

New Journal of Pharmaceutical Analysis Articles Highlight Progress in the Search for Therapies to Treat Challenging Diseases

XI'AN, China, Oct. 25, 2022 /PRNewswire/ -- Although medicine and pharmacology have tremendously progressed over the past few decades, there are still no effective treatment options for certain complex diseases, including cancer, diabetes, and hepatic fibrosis. Researchers, however, continue to reveal mechanisms contributing to the development of these diseases, as well as potential drug targets, helping us develop better therapies. The latest issue of the Journal of Pharmaceutical Analysis features three articles on cutting-edge research targeting challenging diseases. The first study, published in Volume 12, Issue 4 of the journal in August 2022, was conducted by researchers from China and Singapore. They focused on 18beta-glycyrrhetinic acid (18β-GA), a compound naturally occurring in the plant Glycyrrhiza uralensis Fisch, whose root is widely used in traditional Asian medicine to treat hepatic diseases. Through multiple experiments, they demonstrated that 18β-GA can induce cell death in hepatic stellate cells, which are drivers of hepatic fibrosis, by targeting the antioxidants peroxiredoxin 1 and 2 and triggering oxidative stress in the cells. This has important medical implications, as the researchers commented: "Our findings provide strong evidence for the further development of 18β-GA as a therapeutic drug for the treatment of hepatic fibrosis. Understanding the underlying mechanisms of disease development have helped develop better therapeutics for liver diseases, which lead to almost 2 million deaths worldwide every year." In the second article, a review which was published in Volume 12, Issue 4 of the journal in August 2022, researchers from India summarized the latest knowledge on the role of human islet amyloid polypeptide (hIAPP) in the progression of type-2 diabetes mellitus (T2DM). The misfolding and aggregation of hIAPP into amyloid fibrils in the pancreas is one of the pathological hallmarks of T2DM and understanding why it happens, how it affects pancreatic cells, and how it can be stopped or reverted is essential in the context of T2DM. "Designing drugs that prevent hIAPP aggregation or that can eliminate already formed amyloid aggregates would likely help in the management of T2DM. Moreover, these drugs could be repurposed in the future for targeting other protein-misfolding disorders because of the common mechanism underlying these pathologies," the researchers remarked. In the final study, published in Volume 12, Issue 4 of the journal in August 2022, researchers from China screened 43 fluoroquinolone derivatives and tested them as microRNA-21 inhibitors to find a promising anti-cancer compound. Many types of tumor cells overexpress microRNA-21, making it a potential drug target in cancer therapy. Out of all the compounds tested, one named 'A36' proved to be the best microRNA-21 inhibitor. Cell culture experiments showed that A36 produced many of the outcomes that one would hope for in a cancer drug. "At the cellular level, A36 displayed moderate antiproliferative activity against six tumor cell lines, significantly induced apoptosis, arrested cell division, and inhibited colony formation of cancer cells, but exhibited no cytotoxic effects in healthy cell lines," the researchers highlighted. In summary, these studies help explain the pathogenesis of complex diseases like diabetes, cancer, and liver fibrosis while exploring new approaches of treatment and drug targets. Further research in this field will eventually help doctors treat people who suffer from these complex diseases. Reference DOI: Title of original paper: 18beta-glycyrrhetinic acid induces ROS-mediated apoptosis to ameliorate hepatic fibrosis by targeting PRDX1/2 in activated HSCs Journal: Journal of Pharmaceutical Analysis Contact: Fen Qiu +86-131-5206-8068 347162@email4pr.com

21 Jun 2021

·www.globenewswire.com

Electric Bus Charging System Market is expected to Grow at

New York, US, June 21, 2021 (GLOBE NEWSWIRE) -- The global electric bus charging system market is expected to reach from USD 945.3 million in 2019 to USD 2185 million in 2029 as per a new research report by Straits Research. The electric bus charging system market is anticipated to witness significant growth due to the increasing demand for electric vehicles. There is a surge in the utilization of electric bus charging system, owing to the decreasing cost of batteries. The growing efforts to reduce greenhouse gas (GHG) emissions, along with the rise in favorable government regulations have surged its application across the globe. However, the lack of necessary infrastructure and the lack of present resources to meet electricity demand hampers the growth of the market. The electric bus charging system market size is expected to grow USD 2185 million in 2029, with a CAGR of 13.9% in the forecast period 2021 to 2029. Request for a sample of this research report @ Onboard Charging Segment Caters to the Maximum Share in the Electric Bus Charging System MarketThe global electric bus charging system market has been segmented majorly on the basis of charging type, battery type, charging platform, and region. Based on charging type, the market is segmented into on-board charging and off-board charging. Based on battery type market is segmented into lithium iron phosphate, nickel cobalt manganese lithium-ion, and others. Based on charging platform, electric bus charger manufacturers, EV bus manufacturers, Canadian, Chinese electric bus manufacturers, and electric bus charging station cost is segmented majorly impacted on the market. COVID-19 Impact on Automobile Industry The pandemic wreaked havoc on all primary sectors when there was a temporary shutdown of all the events. Industries, such as construction, automobile and aviation, and aerospace and defense, were among the hit majorly, and the damages suffered by companies due to temporary shutdowns impaired production capability, restricting new deployments. Apart from this, the consequences of COVID-19, such as lockdown and social distancing, significantly decreased the automobile sales of electric vehicles and electric bus charging system. In addition, most main players have successfully strategized with other companies and increased their R&D activities to deploy new, effective, hybrid bus, electric bus, and inexpensive solutions. Get Details Insight @ Recent Developments China, India, Japan, and South Korea to Develop Their Charging Infrastructure to Boost the Use of Electric Vehicles (EV) Regionally, Asia-Pacific dominates the electric bus charging system market on account of the rapid technological advancements, presence of industry leaders, and favorable government regulations. Europe is considered a thriving market across the globe and is anticipated to exhibit the fastest growth due to the high adoption of EV by the European countries, massive investments, and the deployments of the latest technology view the details on the regional analysis. Get Regional Analysis and Trends @ Detailed Table of Content 1 Introduction2 Clinical Management Systems Methodology2.1 Primary Research2.2 Research Methodology2.3 Assumptions & Exclusions2.4 Secondary Data Sources3 Market Overview 3.1 Report Segmentation & Scope3.2 Value Chain Analysis: Electric Bus Charging System Market3.3 Key Market Trends3.3.1 Drivers3.3.2 Restraints3.3.3 Opportunities3.4 Porter’s Five Forces Analysis 3.7 Impact of COVID-19 on Electric Bus Charging System Market4 Charging Type Overview 4.1 Introduction4.2 On board charging4.3 Off board charging5 Battery Type Overview 5.1 Introduction5.2 Lithium iron phosphate5.3 Nickel cobalt manganese lithium-ion5.4 Others6 Charging Platform Overview 6.1 Introduction6.2 Depot charging (Plug based)6.3 Opportunity based charging 7 Regional Overview7.1 Introduction7.2 North America7.3 Europe7.4 Asia-Pacific8 Company Profile8.1 ABB8.2 ALSTOM8.3 Furrer+Frey AG.8.4 Heliox8.5 PROTERRA8.6 Siemens8.7 Others The EV sales had been increased by a whopping 63 % in 2017 as compared to 2016. By 2040, it has been estimated that the number of EVs to reach 35% of all vehicles. This is mainly attributed to the steep reduction in the cost of battery technology and decarbonized policies of governments worldwide. As per the Bloomberg New Energy Finance estimates, the sale of electric buses is expected to reach 1.25 million units by 2025. Electric Bus Charging System Market: Information by Charging Type, Battery Type (Lithium Iron Phosphate), Charging Platform (Depot Charging), and Region — Forecast till 2029 Buy Full Research Report of Electric Bus Charging System @ Have a Look at Related Research Report Battery Materials Market: Information by Battery Type (Lead-acid), Material Type (Cathode), Application (Portable Devices, Automotive), and Region-Forecast till 2029 Electric Bus Market: Information by Vehicle (Battery, Plug-In, and Hybrid), Consumer (Public and Private), and Region—Forecast till 2029 Wireless Car Charging Market: Information by Charging Type (Dynamic Wireless Charging Systems), Vehicle Type (Hybrid Electric Cars), and Technology, and Region — Forecast till 2029 Electric Utility Vehicle Market: Information by Type (Battery Acid, Gel Lead) Application (Logistics & Delivery Industry, Public Sector, Agriculture) Regional Outlook — Forecast Till 2026 Electronic Components Market: Information by Type (Passive, Active, and Electro mechanic), Application (Automotive, Computing Application, Others), and Region–Forecast till 2029 Battery Management IC Market: Information by Type (Battery Charger IC, Fuel Gauge IC, and Authentication IC), Application (Healthcare and Automotive), and Region — Forecast till 2029 About Straits Research StraitsResearch is a market intelligence company providing global business information reports and services. Our exclusive blend of quantitative forecasting and trends analysis provides forward-looking insight for thousands of decision-makers. Straits Research provides the actionable market research data specially designed and presented for decision-making and ROI. Regardless of whether you're looking at business sectors in the next town or crosswise over continents, we understand the significance of being acquainted with what customers purchase. We overcome the issues of our customers by recognizing and deciphering just the target group, while simultaneously generating leads with the highest precision. We seek to collaborate with our customers to deliver a broad spectrum of results through a blend of market and business research approaches. So let's put our minds together. We'll make your vision a reality and help you grow.

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16 Jun 2021

·www.globenewswire.com

Metallic Powder Coatings Market to Reach USD 2.91 billion by 2028; Increasing Demand for Eco-friendly Coatings to Stimulate Growth: Fortune Business Insights™

Pune, India, June 16, 2021 (GLOBE NEWSWIRE) -- The global metallic powder coating market size is expected to experience considerable growth by reaching USD 2.91 billion by 2028 while exhibiting a CAGR of 6.5% between 2021 and 2028. Fortune Business Insights in its report, titled “Metallic Powder Coating Market Size, Share & COVID-19 Impact Analysis, By Resin Type (Epoxy Polyester, Polyester, Epoxy, Polyurethane, and Others), By Process (Bonding, Dry Blending, and Co-Extrusion), By Pigment (Aluminum, Mica, and Others), By Application (Architectural, Automotive, Appliance, Furniture, Leisure Equipment, and Others), and Regional Forecast, 2021-2028.”, mentions that the market stood at USD 1.75 billion in 2020. The increasing demand for eco-friendly powder coatings worldwide is expected to propel the market’s growth in the forthcoming years. The drastic effect of the global pandemic, COVID-19, has been felt across several economies facing unprecedented loss. The lockdown imposed by the government agencies has led to several industries facing halted industrial operations. However, a collective effort from the government and the industries is likely to bring the economy back on track and aid in the resumption of industrial activities. Get Sample PDF Brochure with Impact of COVID19: Market Segmentation: Based on the resin type, the market is classified into epoxy polyester, polyester, epoxy, polyurethane, and others. On the basis of resin type, the epoxy polyester segment is anticipated to hold significant global metallic powder coatings market share in the forthcoming years. This is owing to the several benefits of epoxy polyester such as high chemical and corrosion tolerance to ant powder and wide availability of the product worldwide. Based on the process, the market is trifurcated into bonding, dry blending, and co-extrusion. On the basis of pigment, the market is divided into aluminum, mica, and others. Furthermore, based on application, the market is segmented into architectural, automotive, appliance, furniture, leisure equipment, and others. Lastly, on the basis of region, the market is segregated into Asia-Pacific, Europe, North America, Latin America, and the Middle East and Africa. What does the Report Provide? The global market report provides an in-depth analysis of several factors such as the key drivers and restraints that will impact growth. Additionally, the report provides insights into the regional analysis that covers different regions, contributing to the growth of the market. It includes the competitive landscape that involves the leading companies and the adoption of strategies by them to introduce new products, announce partnerships, and collaboration that will further contribute to the market growth. Moreover, the research analyst has adopted several research methodologies such as PESTEL and PORTER’s Five Point Analysis to obtain information about the current trends and industry developments that will drive the market growth in the forthcoming years. DRIVING FACTORS Increasing Demand for Eco-friendly Coatings to Augment Growth According to the American Lung Association, volatile organic compounds (VOCs) that are present in coatings, paints, adhesives, etc., can lead to adverse health effects such as nausea, difficulty to breathe, irritation of eyes, throat, and nose, among others. Moreover, ozone pollution due to excessive adoption of such compounds is leading to air pollution worldwide. Therefore, to reduce the harmful effect of solvent-based coatings, there is a high demand for eco-friendly coatings across several industrial applications. These coatings are manufactured without using petroleum solvents and do not emit toxic VOCs. Moreover, they comply with environmental standards and their growing adoption is expected to contribute to the global metallic powder coating market growth in the forthcoming years. Inquire Before Buying This Research Report: REGIONAL INSIGHTS Asia-Pacific to Remain Dominant; Rising Automotive Sector to Aid Growth Among all the regions, Asia-Pacific is expected to remain at the forefront and hold the highest position in the market in the forthcoming years. This is attributable to the rising automotive and electronics industries in countries such as Thailand, China, South Korea, India, and Taiwan. According to Reuters, the overall vehicle sales in China in December 2020 reached around 2.83 million vehicles, a gradual rise of over 6.4% compared to the same period last year. Asia Pacific stood at USD 0.90 billion in 2020. The market in North America is expected to showcase considerable growth backed by the growing awareness regarding the adverse effects of solvent-based coatings that is expected to boost the adoption of eco-friendly metallic powder coatings in the region between 2021 and 2028. COMPETITIVE LANDSCAPE Contract Signing by Major Companies to Expand Their Product Portfolio and Boost Sales Revenue The market comprises small, medium, and large companies striving to maintain their presence by signing strategic contracts with government agencies and private companies to expand their metallic powder coatings product portfolio. Moreover, other key players are adopting strategies such as merger and acquisition, the introduction of new products, partnership, and facility expansion that will favor the growth of the market in the forthcoming years. List of the Companies Operating in the Global Market for Metallic Powder Coatings: Browse Detailed Summary of Research Report with TOC: Key Industry Development: Detailed Table of Content: TOC Continued…! Speak to Our Expert: Have a Look at Related Research Insights: Activated Carbon Market Size, Share & Industry Analysis, By Form (Powdered, Granular, and Others), By Application (Water Treatment, Air & Gas Purification, Food & Beverage, Others), and Regional Forecast, 2019-2026 Castor Oil Derivatives Market Size, Share & COVID-19 Impact Analysis, By Product Type (Sebacic Acid, Ricinoleic Acid, Hydrogenated Castor Oil, 12-Hydroxy Stearic Acid, Dehydrated Castor Oil and Others), Application (Cosmetic & Pharmaceuticals, Plastic & Resins, Lubricants, Biodiesel, and Others) and Regional Forecast, 2020-2027 Cold Chain Packaging Refrigerants Market Size, Share & COVID-19 Impact Analysis, By Product type (Gel Packs, Foam Bricks, and Others), By Application (Pharmaceuticals, Food, and Industrial) and Regional Forecast, 2020-2027 Self-Adhesive Labels Market Size, Share & COVID-19 Impact Analysis, By Type (Linerless, Release Liner), By Label Type (Permanent, Removable), By Application (Food & Beverages, Pharmaceutical, Household & Personal Care, Consumer Goods, Others), and Regional Forecast, 2020-2027 About Us: Fortune Business Insights™ delivers accurate data and innovative corporate analysis, helping organizations of all sizes make appropriate decisions. We tailor novel solutions for our clients, assisting them to address various challenges distinct to their businesses. Our aim is to empower them with holistic market intelligence, providing a granular overview of the market they are operating in. Contact Us: Fortune Business Insights™ Pvt. Ltd. 308, Supreme Headquarters, Survey No. 36, Baner, Pune-Bangalore Highway, Pune - 411045, Maharashtra, India. Phone: US :+1 424 253 0390 UK : +44 2071 939123 APAC : +91 744 740 1245 Email: sales@fortunebusinessinsights.com Connect us via Social Media Channels: LinkedIn: Facebook: Twitter:

Acquisition

100 Deals associated with Glycyrrhetinic Acid

External Link

KEGG	Wiki	ATC	Drug Bank
D00156	Glycyrrhetinic Acid	D03AX10	DB13089

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Eczema	JP	Mayado Pharmaceutical Co., Ltd.	19 Aug 1965
Neurodermatitis	JP	Mayado Pharmaceutical Co., Ltd.	19 Aug 1965
Pruritus	JP	Mayado Pharmaceutical Co., Ltd.	19 Aug 1965

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01576783 (CTgov)	Phase 4	Obstetric Labor, Premature	377	Arachidonic Acid+Docosahexaenoic Acid (Docosahexaenoic Acid + Arachidonic Acid)	jaaiumrexc(qoqejwgcep) = azqrcmmyve wxjunsrwdu (hhsxsptxhg, qsiekjlyxz - oncsedssai) View more	-	24 May 2019
				Placebo (Placebo)	jaaiumrexc(qoqejwgcep) = qgmegjljhg wxjunsrwdu (hhsxsptxhg, hgjzwudnxf - fwpenkjquw) View more
NCT01661764 (CTgov)	Phase 2	Adenomatous Polyposis Coli	141	Eicosapentanoic acid+docosahexanoic acid (rs174535 (GG), Fish Oil Supplements)	mtgqxcsgxs(xdfodfiieu) = xtcwjyhldc usbmuvbdjq (zbqawtczhx, hrnyomoxfy - euntmfmwvh) View more	-	08 May 2018
				Oleic Acid (rs174535 (GG), Placebo)	mtgqxcsgxs(xdfodfiieu) = rmctybqhum usbmuvbdjq (zbqawtczhx, edfseuirql - pbvriwdgpz) View more

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