Last update 11 Jul 2024

9MW-2821

Overview

Basic Info

Drug Type
Antibody drug conjugate (ADC)
Synonyms
Anti-nectin-4 IgG1 monoclonal antibody conjugated to monomethyl auristatin E (Mabwell)
+ [1]
Mechanism
Tubulin inhibitors, nectin-4 inhibitors(Nectin-4 inhibitors)
Inactive Indication-
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (US), Orphan Drug (US)

Structure

Molecular FormulaC37H48F2N6O14
InChIKeyFDMCGECBOYCLOR-XBURZOHBSA-N
CAS Registry-
View All Structures (2)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Transitional Cell CarcinomaPhase 3
CN
31 Dec 2023
Triple Negative Breast CancerPhase 2-01 Jul 2024
Advanced Malignant Solid NeoplasmPhase 2
CN
11 Jun 2022
Uterine Cervical CancerPhase 2
CN
-
Solid tumorPhase 1
US
29 Jul 2022
Esophageal CarcinomaPreclinical
US
06 May 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
190
9MW2821 at 1.25mg/kg or above
(UC)
(dtccqbgilu) = xetiownygh tpslkwxzse (fnqaiofaae, 44.76-77.54)
Positive
25 May 2024
9MW2821 at 1.25mg/kg or above
(CC)
(dtccqbgilu) = kchsukbpji tpslkwxzse (fnqaiofaae, 23.77-53.46)
Phase 1/2
20
(hlidynembf) = xgvirgfovg tvzdfpwots (vmtqgblrkm )
Positive
13 May 2024
Phase 1/2
40
(phuplpdmdp) = bvxputocos qhvooeezpt (anlsrmtzdh )
Positive
18 Mar 2024
NEWS
ManualManual
Phase 2
-
9MW2821 1.25mg/kg
(mujznsavjl) = trfbxgvpxr qauhlwzixo (fquoiikvgl, 44.8 - 77.5)
Positive
07 Dec 2023
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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