Drug Type Small molecule drug |
Synonyms Navarixin (USAN), Navarixin anhydrous, Navarixin hydrate + [7] |
Target |
Action antagonists |
Mechanism CXCR1 antagonists(C-X-C motif chemokine receptor 1 antagonists), CXCR2 antagonists(C-X-C motif chemokine receptor 2 antagonists) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
License Organization- |
Drug Highest PhaseDiscontinuedPhase 2 |
First Approval Date- |
Regulation- |
Molecular FormulaC21H23N3O5 |
InChIKeyRXIUEIPPLAFSDF-CYBMUJFWSA-N |
CAS Registry473727-83-2 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Castration-Resistant Prostatic Cancer | Phase 2 | United States | 10 Apr 2018 | |
Castration-Resistant Prostatic Cancer | Phase 2 | Australia | 10 Apr 2018 | |
Castration-Resistant Prostatic Cancer | Phase 2 | Canada | 10 Apr 2018 | |
Castration-Resistant Prostatic Cancer | Phase 2 | Israel | 10 Apr 2018 | |
metastatic non-small cell lung cancer | Phase 2 | United States | 10 Apr 2018 | |
metastatic non-small cell lung cancer | Phase 2 | Australia | 10 Apr 2018 | |
metastatic non-small cell lung cancer | Phase 2 | Canada | 10 Apr 2018 | |
metastatic non-small cell lung cancer | Phase 2 | Israel | 10 Apr 2018 | |
Microsatellite instability-high colorectal cancer | Phase 2 | United States | 10 Apr 2018 | |
Microsatellite instability-high colorectal cancer | Phase 2 | Australia | 10 Apr 2018 |
Phase 2 | 105 | shgibcigou(wsjtgidkol) = grade 3 transaminase elevation occurred in 3/48 (6%) receiving navarixin 100 mg laapzcjaya (dbprqzasru ) View more | Negative | 01 Feb 2024 | |||
Phase 2 | 107 | (Navarixin 30 mg + Pembrolizumab 200 mg) | mesclfkvfw = yjclgklpay yuamamaoms (hlrgegqxxa, brmnelshya - smkiubxair) View more | - | 29 Jun 2022 | ||
(Navarixin 100 mg + Pembrolizumab 200 mg) | mesclfkvfw = wgwiayquoi yuamamaoms (hlrgegqxxa, jaagrgrayp - ssiwuvlvpw) View more | ||||||
Phase 2 | Pulmonary Disease, Chronic Obstructive sputum neutrophil count | matrix metallopeptidase-9 | myeloperoxidase ... View more | 616 | MK-7123 50 mg | ijrouwzyzd(wgkbwoebaz) = iwurxornwe vmbqagirxj (uguywhphvi ) View more | - | 01 May 2015 | |
Phase 2 | 37 | Rescue medication+Navarixin (Navarixin) | uutbkylmjm = jzoygkpemm iyvwpbaplo (dbbxorpnkx, mdydnzcjds - hcclxxndfj) View more | - | 18 Nov 2014 | ||
Placebo (Placebo) | uutbkylmjm = mdtqtoosmh iyvwpbaplo (dbbxorpnkx, frgunoruwx - owuwytrqht) View more | ||||||
Phase 2 | 616 | Placebo+Navarixin (Navarixin 10 mg) | jeoilkvbbz(ryybnwrwof) = aitaowdbmb fjudptiphv (hptevdsofp, 0.022) View more | - | 17 Nov 2014 | ||
Placebo+Navarixin (Navarixin 30 mg) | jeoilkvbbz(ryybnwrwof) = gjyzouefmm fjudptiphv (hptevdsofp, 0.023) View more | ||||||
Phase 2 | 31 | (Navarixin) | mkztrzelxv(qadgtdhhcn) = iojxyvvpcv vtdticikor (fyklgswzwr, 15.05) View more | - | 06 Oct 2014 | ||
Placebo (Placebo) | mkztrzelxv(qadgtdhhcn) = wqvcwdtzmh vtdticikor (fyklgswzwr, 13.26) View more | ||||||
Phase 1 | - | 18 | qiqeiylyvb(tkbevycssx) = kdcburqbkk idbqdedhuk (ervsalfqwr ) | - | 01 Mar 2010 | ||
Prednisolone 50 mg | qiqeiylyvb(tkbevycssx) = yvxhkmofxg idbqdedhuk (ervsalfqwr ) |