Delving into the Latest Updates on Bovine lactoferrin (University of Queensland) with Synapse

Overview

Basic Info

Drug Type

Recombinant protein

Synonyms-

Target

LTF

Action

stimulants

Mechanism

LTF stimulants(Lactotransferrin stimulants)

Therapeutic Areas

Infectious DiseasesOther Diseases

Active Indication

Infectious DiseasesInflammation

Inactive Indication-

Originator Organization

The University of Queensland

Active Organization

The University of Queensland

Inactive Organization-

License Organization-

Drug Highest PhaseClinical

First Approval Date-

Regulation-

Bovine viral diarrhea virus (BVDV) infection represents a significant economic challenge to the global cattle industry, leading to considerable losses in productivity and increased management costs. This underscores the urgent need for effective antiviral strategies to combat BVDV infection. In this study, we demonstrated that bovine lactoferrin (bLF), a multifunctional glycoprotein with known antimicrobial properties, exhibited potent inhibitory activity against BVDV infection. Importantly, the antiviral effect of bLF was not mediated by cytotoxicity towards host cells, indicating its safety for potential applications. Mechanistic investigations revealed that bLF did not interfere with viral RNA translation or replication, nor did it impair viral assembly or release. Instead, bLF effectively blocked BVDV infection during the early stages of the viral lifecycle, likely by competitively binding to cellular receptor molecules involved in viral entry. These findings identify bLF as a promising candidate for the development of antivirals targeting BVDV infection, offering a novel and effective approach to managing BVDV-associated diseases.

01 Apr 2025·Poultry Science

Bamboo leaf flavonoids ameliorate cyclic heat stress-induced oxidative damage in broiler liver through activation of Keap1-Nrf2 signaling pathway

Article

Author: Miao, Jiajun ; Xiong, Yongjie ; Zhang, Xueqi ; Yuan, Junjun ; Li, Yan ; He, Shaojun ; Ma, Feiyang ; Ding, Jinxue

Heat stress (HS) induces oxidative stress in the liver and affects health and production attributes in poultry birds. Bamboo leaf flavonoid (BLF) is a natural plant flavonoid that is effective in controlling oxidative stress. Therefore, the aim of current study was to investigate the impact of BLF on growth performance, liver index, serum biochemical parameters of liver function, liver antioxidant enzyme activities, and expression of genes and proteins related to the liver Keap1-Nrf2 system in cyclic heat stress (CHS) broilers. Twenty-eight-day old Arbor Acres broilers (n = 200) were randomly assigned to 5 groups. TN group fed basal diet was reared in a thermoneutral environment (24 ± 1 °C); CHS, 400 mg/kg BLF + CHS, 800 mg/kg BLF + CHS, and 1600 mg/kg BLF + CHS groups were reared in high temperature conditions (33 ± 1 °C, 8 h/day), with the basal diet supplemented with 0, 400, 800, and 1600 mg/kg BLF. The results indicated that ADG and ADFI of broilers in 28 to 35d and 36 to 42d CHS groups were significantly lower compared to the TN group. BLF improves growth performance of CHS broilers by increasing ADG, ADFI and decreasing F:G. BLF improved live weight, liver weight, liver index and reduced serum AST, ALP, ALT, T-BIL levels and increased TP levels in CHS broilers. Meanwhile, BLF supplementation enhanced the activity of hepatic antioxidant enzymes, resulting in higher T-AOC, CAT, GSH-PX and T-SOD levels than those of CHS broilers, and significantly reduced MDA levels. In addition, BLF down-regulated the protein levels of Keap1 and P62, increased the expression levels of Nrf2 genes and proteins, and activated the expression of its downstream NQO1, HO-1, and SOD-1 antioxidant genes compared to CHS broilers. In summary, BLF regulates the expression of key genes and proteins in the Keap1-Nrf2 signaling pathway to alleviate liver injury in broilers by inhibiting oxidative stress, thereby promoting the growth performance of broilers with CHS.

01 Mar 2025·Food Chemistry

Structural characteristics and antioxidant activity of binary compounds formed by covalent modification of plant derived recombinant lactoferrin (OsrhLF) with four typical carbohydrates

Article

Author: Guan, Xiaoyan ; Wu, Yeting ; Xia, Zixian ; Xu, Jing ; Liu, Rui ; Lu, Youyou ; Wang, Kexin ; Shao, Yanchun

Lactoferrin is crucial for the mammalian immune system, but the extraction of bovine lactoferrin (bLF) is low, and human lactoferrin in breast milk is costly. Although there are some reports on heterologous expression of lactoferrin, limited knowledge is available. In this study, structural characteristics and antioxidant activity of binary compounds formed by covalent modification of plant derived recombinant human lactoferrin (OsrhLF) with four typical carbohydrates including sodium alginate (SA), maltodextrin (Mal), pectin (Pec), and lactose (Lac). Results indicated that the structure of both bLF and OsrhLF unfolded, with side chain lysine or terminal amino acids forming CN bonds with aldehydes, altering their structure and improving stability and hydrophilicity. Compared with OsrhLF, the thermal denaturation temperatures of H-OsrhLF-Mal and H-OsrhLF-Lac increased by 56.8 °C and 58.4 °C, respectively. OsrhLF exhibited superior surface hydrophilicity and thermal stability compared to bLF, with Mal showing the most significant effect, aiding future functional food applications.

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