Last update 13 Aug 2025

AntiALPP CART cells (TCRCure Biotech)

Overview

Basic Info

Drug Type
Autologous CAR-T
Synonyms
CARsT therapy TCRCure Biotech, Retroviral vector-transduced anti-ALPP CARs-T therapy, TC-A101
Target
ALPP
Action
inhibitors
Mechanism
ALPP inhibitors(alkaline phosphatase, placental inhibitors), Gene transference(Gene transference), T lymphocyte replacements
Therapeutic Areas
NeoplasmsRespiratory DiseasesUrogenital Diseases
Active Indication
Advanced Malignant Solid NeoplasmFemale Genital NeoplasmsLung Cancer
Inactive Indication
Endometrial CarcinomaOvarian Epithelial CarcinomaTesticular Neoplasms+ [1]
Originator Organization
Guangdong Tcrcure Biopharma Technology Co. Ltd.Guangdong Tcrcure Biopharma Technology Co. Ltd.
Active Organization
Guangdong Tcrcure Biopharma Technology Co. Ltd.Guangdong Tcrcure Biopharma Technology Co. Ltd.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Related

3
Clinical Trials associated with AntiALPP CART cells (TCRCure Biotech)
NCT07108140
/ RecruitingEarly Phase 1
A Single-Arm, Single-Center, Open-Label Pilot Study of Patients With ALPP-Positive Advanced Solid Tumors
NCT04627740
/ RecruitingPhase 1/2IIT
A Single-Arm, Single-Center, Open-Label Pilot Study of Anti-ALPP CART-cells in Patient With Alkaline Phosphatase, Placental (ALPP)-Positive Advanced Solid Tumor
NCT06556108
/ RecruitingPhase 1/2IIT
A Single-Arm, Single-Center, Open-Label Pilot Study of Anti-ALPP CAR-T Cells for Alkaline Phosphatase, Placental (ALPP)-Positive Advanced Solid Tumors
100 Clinical Results associated with AntiALPP CART cells (TCRCure Biotech)
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100 Translational Medicine associated with AntiALPP CART cells (TCRCure Biotech)
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100 Patents (Medical) associated with AntiALPP CART cells (TCRCure Biotech)
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100 Deals associated with AntiALPP CART cells (TCRCure Biotech)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 2
China
Guangdong Tcrcure Biopharma Technology Co. Ltd.Guangdong Tcrcure Biopharma Technology Co. Ltd.
01 Dec 2020
Female Genital NeoplasmsPhase 1
China
Guangdong Tcrcure Biopharma Technology Co. Ltd.Guangdong Tcrcure Biopharma Technology Co. Ltd.
-
Lung CancerPhase 1
China
Guangdong Tcrcure Biopharma Technology Co. Ltd.Guangdong Tcrcure Biopharma Technology Co. Ltd.
-
Endometrial CarcinomaPreclinical
China
Guangdong Tcrcure Biopharma Technology Co. Ltd.Guangdong Tcrcure Biopharma Technology Co. Ltd.
30 Dec 2020
Ovarian Epithelial CarcinomaPreclinical
China
Guangdong Tcrcure Biopharma Technology Co. Ltd.Guangdong Tcrcure Biopharma Technology Co. Ltd.
30 Dec 2020
Testicular NeoplasmsPreclinical
China
Guangdong Tcrcure Biopharma Technology Co. Ltd.Guangdong Tcrcure Biopharma Technology Co. Ltd.
30 Dec 2020
Uterine Cervical CancerPreclinical
China
Guangdong Tcrcure Biopharma Technology Co. Ltd.Guangdong Tcrcure Biopharma Technology Co. Ltd.
30 Dec 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NCT04627740 (ESMO2022)
ManualManual
Phase 1
Endometrioid carcinoma ovary
ALPP
3
ppdvgoomxu(psxorkmjqf) = none gwlppfggqf (xlhmlycpwq )
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Positive
10 Sep 2022
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Clinical Trial

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Approval

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Regulation

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