Last update 20 Mar 2025

AntiALPP CART cells (TCRCure Biotech)

Overview

Basic Info

Drug Type
Autologous CAR-T
Synonyms
CARsT therapy TCRCure Biotech, Retroviral vector-transduced anti-ALPP CARs-T therapy
Target
ALPP
Action
inhibitors
Mechanism
ALPP inhibitors(alkaline phosphatase, placental inhibitors), Gene transference, T lymphocyte replacements
Therapeutic Areas
Neoplasms
Active Indication
Advanced Malignant Solid Neoplasm
Inactive Indication
Endometrial CarcinomaOvarian Epithelial CarcinomaTesticular Neoplasms+ [1]
Originator Organization
Beijing TCR CURE Biopharma Technology Co., LtdBeijing TCR CURE Biopharma Technology Co., Ltd
Active Organization
Beijing TCR CURE Biopharma Technology Co., LtdBeijing TCR CURE Biopharma Technology Co., Ltd
Inactive Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with AntiALPP CART cells (TCRCure Biotech)
NCT04627740
/ RecruitingPhase 1/2IIT
A Single-Arm, Single-Center, Open-Label Pilot Study of Anti-ALPP CART-cells in Patient With Alkaline Phosphatase, Placental (ALPP)-Positive Advanced Solid Tumor
100 Clinical Results associated with AntiALPP CART cells (TCRCure Biotech)
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100 Translational Medicine associated with AntiALPP CART cells (TCRCure Biotech)
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100 Patents (Medical) associated with AntiALPP CART cells (TCRCure Biotech)
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100 Deals associated with AntiALPP CART cells (TCRCure Biotech)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 2
China
Beijing TCR CURE Biopharma Technology Co., LtdBeijing TCR CURE Biopharma Technology Co., Ltd
01 Dec 2020
Endometrial CarcinomaPhase 1
China
Beijing TCR CURE Biopharma Technology Co., LtdBeijing TCR CURE Biopharma Technology Co., Ltd
30 Dec 2020
Ovarian Epithelial CarcinomaPhase 1
China
Beijing TCR CURE Biopharma Technology Co., LtdBeijing TCR CURE Biopharma Technology Co., Ltd
30 Dec 2020
Testicular NeoplasmsPhase 1
China
Beijing TCR CURE Biopharma Technology Co., LtdBeijing TCR CURE Biopharma Technology Co., Ltd
30 Dec 2020
Uterine Cervical CancerPhase 1
China
Beijing TCR CURE Biopharma Technology Co., LtdBeijing TCR CURE Biopharma Technology Co., Ltd
30 Dec 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NCT04627740 (ESMO2022)
ManualManual
Phase 1
Endometrioid carcinoma ovary
ALPP
3
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Positive
10 Sep 2022
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Approval

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Regulation

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