Delving into the Latest Updates on Methacholine Chloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Kenbran Powder, Methacholine chloride (JAN/USP/INN), Provocholine Powder

+ [10]

Target

mAChRs

Mechanism

mAChRs agonists(Muscarinic acetylcholine receptor agonists)

Therapeutic Areas

Immune System DiseasesRespiratory DiseasesOther Diseases

Active Indication

Diagnostic agentsRespiratory HypersensitivityAsthma

Inactive Indication-

Originator Organization

Methapharm, Inc.

Active Organization

Santen Pharmaceutical Co., Ltd.

Sanwa Kagaku Kenkyusho Co., Ltd.

Methapharm, Inc.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

US (31 Oct 1986),

Asthma

Regulation-

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Structure

Molecular FormulaC8H18ClNO2

InChIKeyJHPHVAVFUYTVCL-UHFFFAOYSA-M

CAS Registry62-51-1

OBJECTIVETo evaluate the safety of an abbreviated methacholine challenge test (MCT) protocol in children.STUDY DESIGNThis prospective, observational study enrolled children aged 6 through 18 years referred for the MCT. The abbreviated protocol was initiated with a methacholine dose of 0.03 mg/ml and escalated in fourfold increments, unless the forced expiratory volume at 1 second decline exceeded 10%, at which point the next dose was only doubled. The safety of this abbreviated approach was assessed by monitoring adverse events, and specifically, decreases in forced expiratory volume at 1 second over 40%, hypoxemia, or uncontrollable cough. The number of methacholine doses and test duration were recorded and compared with estimated outcomes derived from the full-length MCT protocol.RESULTSOne hundred twelve participants, aged 13.7 years (±3.3), successfully completed the protocol. Fifty-seven (51%) presented a positive MCT response. No significant clinical adverse events were observed. Of all participants, 2.7% exhibited an exaggerated response, in line with previously reported findings for the full-length protocol. The abbreviated approach resulted in an estimated average time-savings of 18:19 minutes per participant, thus reducing test length by 22:47 minutes for a negative MCT and by 14:34 minutes for a positive outcome.CONCLUSIONSThis abbreviated MCT protocol is safe for children and effectively shortens the duration of the MCT.

01 Dec 2024·Biological Trace Element Research

Retraction Note: Effects of Cadmium Chloride and Sodium Selenite Alone or in Combination on the Liver of Male Sprague–Dawley Rats Assessed by Different Assays

Author: Jabeen, Farhat ; Chaudhry, Abdul Shakoor

01 Dec 2024·Applied Microbiology and Biotechnology

Distinction of chia varieties in vivo and in vitro based on the flow cytometry and rosmarinic acid production

Article

Author: Szopa, Agnieszka ; Motyka, Sara ; Ochatt, Sergio J

AbstractFlow cytometry has made a significant contribution to the study of several complex fundamental mechanisms in plant cytogenetics, becoming a useful analytical tool to understand several mechanisms and processes underlying plant growth, development, and function. In this study, the genome size, DNA ploidy level, and A-T/G-C ratio were measured for the first time for two genotypes of chia, Salvia hispanica, an herbaceous plant commonly used in phytotherapy and nutrition. This study also evaluated, for the first time by flow cytometry, the capacity to produce organic acids of tissues stained with LysoTracker Deep Red after elicitation with either yeast extract or cadmium chloride. Rosmarinic acid content differed between the two chia varieties treated with different elicitor concentrations, compared with non-elicited plant material. Elicited tissues of both varieties contained a higher content of rosmarinic acid compared with non-elicited cultures, and cadmium chloride at 500 μM was much better than that at 1000 μM, which led to plant death. For both genotypes, a dose-response was observed with yeast extract, as the higher the concentration of elicitor used, the higher rosmarinic acid content, resulting also in better results and a higher content of rosmarinic acid compared with cadmium chloride. This study demonstrates that flow cytometry may be used as a taxonomy tool, to distinguish among very close genotypses of a given species and, for the first time in plants, that this approach can also be put to profit for a characterization of the cytoplasmic acid phase and the concomitant production of secondary metabolites of interest in vitro, with or without elicitation.Key points• Genome size, ploidy level, A-T/G-C ratio, and cytoplasm acid phase of S. hispanica• Cytometry study of cytoplasm acid phase of LysoTracker Deep Red-stained plant cells• Yeast extract or cadmium chloride elicited rosmarinic acid production of chia tissuesGraphical Abstract

2

News (Medical) associated with Methacholine Chloride

09 Nov 2023

·www.kamada.com

All Our Products - Kamada Pharmaceuticals

AEROBIKA BRAMITOB Cytogam ELIGARD FOSTER Gammaplex Glassia HepaGam B Hepatect CP INTRATECT IXIARO KAM-RHO D I.M KAM-RHO D I.V KamRAB LAMZEDE Megalotect CP OPTIVATE 1000 Provocholine REPLENINE – VF 1000 Ruconest RUPAFIN Varitect CP Varizig WinRho ZENALB Zutectra

11 Jul 2018

·www.kamada.com

Distribution Products - Kamada Pharmaceuticals

AEROBIKA BRAMITOB ELIGARD FOSTER Gammaplex Hepatect CP INTRATECT IXIARO LAMZEDE Megalotect CP OPTIVATE 1000 Provocholine REPLENINE – VF 1000 Ruconest RUPAFIN Varitect CP ZENALB Zutectra

100 Deals associated with Methacholine Chloride

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External Link

KEGG	Wiki	ATC	Drug Bank
D04970	Methacholine Chloride	V04CX	DBSALT001175

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Diagnostic agents	JP	Santen Pharmaceutical Co., Ltd.	22 Jan 2016
Respiratory Hypersensitivity	JP	Santen Pharmaceutical Co., Ltd.	22 Jan 2016
Asthma	US	Methapharm, Inc.	31 Oct 1986

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Asthma	Preclinical	JP	Santen Pharmaceutical Co., Ltd.	01 Feb 2014

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01547286 (CTgov)	Not Applicable	Allergic asthma	7	Computed Tomography imaging, functional Positron Emission Tomography imaging+Nebulized methacholine inhalation	zmuctfuwiw(huojtqbyaq) = hfwnebamwn fbkkcohcal (rfozxncfas, hiaslsafvb - mjhqxzleso) View more	-	25 Apr 2017
NCT02097537 (CTgov)	Phase 3	Asthma	10	Methacholine Chloride (SK-1211)	ymmootposa(xhkgnrntvs) = lwlabskrfr jjqygpcsid (tbhawjbxhn, fpnolvvtgq - evrkmfxmbt) View more	-	14 Feb 2017