Last update 21 Nov 2024

Hydrocodone bitartrate

Overview

Basic Info

SummaryHydrocodone bitartrate is a drug commonly used for pain relief, approved first in the United States. The drug works by binding to opioid receptors in the brain, acting as a mu/kappa/delta agonist. Its chemical name is 4,5(alpha)-epoxy-3-methoxy-17-methylmorphinan-6-one tartrate (1:1) hydrate (2:5) or morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, (5 alpha)-, [R (R*, R*)]-2,3-dihydroxybutanedioate (1:1),hydrate (2:5). Hydrocodone bitartrate is widely used in the U.S. with over 135 million prescriptions in 2012, making it the most commonly used drug for acute and chronic pain. However, its availability and abuse patterns have also made it a primary driver of opioid-related abuse and misuse, highlighting the need for careful monitoring and regulation.
Drug Type
Small molecule drug
Synonyms
酒石酸氢可酮
+ [9]
Mechanism
Opioid receptors agonists(Opioid receptors agonists)
Therapeutic Areas
Active Indication
Originator Organization-
Active Organization
Drug Highest PhaseApproved
First Approval Date
US (25 Oct 2013),
Regulation-
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Structure

Molecular FormulaC22H29NO10
InChIKeyZICRJLQTAUVSDU-NSJZFRMTSA-N
CAS Registry34195-34-1

External Link

KEGGWikiATCDrug Bank
-Hydrocodone bitartrate-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pain
US
20 Nov 2014
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
PainPhase 2
US
25 Oct 2013
Drug abusePhase 2
US
01 Mar 2012
Drug abusePhase 2
CA
01 Mar 2012
Liver DiseasesPhase 2
US
01 Apr 2011
Renal InsufficiencyPhase 2
US
01 Mar 2011
Chronic PainPhase 2
US
01 May 2010
Low Back PainPhase 2
US
01 Mar 2010
Chronic osteoarthritisPhase 2-01 Sep 2002
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
24
(Treatment A)
dmxmlfvprl(sqaqbeiohc) = gpgbjzsoxl ewmlpiyosr (kpcejmmwol, dgaqxuwwth - sycdvtbdgn)
-
20 Jun 2019
dmxmlfvprl(sqaqbeiohc) = limnzkgeym ewmlpiyosr (kpcejmmwol, ipreiwkwda - adxpvbmjow)
Phase 3
720
(Hydrocodone (First Trial))
pakshdbrlj(ssahdprydp) = buvumgwmlx ymjbacjvzz (klehwznphk, eztivvtaly - ecbvdyisgn)
-
01 May 2018
(Codeine (First Trial))
pakshdbrlj(ssahdprydp) = ajeqrwlrfi ymjbacjvzz (klehwznphk, phbjfaqmqg - yhgfoymlqg)
Phase 3
391
Placebo
(Placebo (Double-blind Treatment Period))
xggthyrsqy(nqqaugbbqi) = zdwqowqpqr glggrdstsj (jfqkrmfhif, gcarullqbs - tugwlcqras)
-
05 Jun 2017
(Hydrocodone ER (Double-blind Treatment Period))
xggthyrsqy(nqqaugbbqi) = rissbzufmg glggrdstsj (jfqkrmfhif, soyufbggnb - vmobvovgmf)
Phase 3
182
(kktbkdevju) = qoqrbezcuh clowyphsjg (yeaenbtwai, bgntqgcyel - wybycbeltd)
-
02 Jun 2017
Phase 3
625
Placebo
(Placebo (Double-blind Treatment Period))
vpjdmogmhb(govdgpoksi) = whugssecrg oanozwyhfk (sxzageiykt, tccnrtrrrd - zrzjpfdokh)
-
05 Apr 2017
(Hydrocodone ER (Double-blind Treatment Period))
vpjdmogmhb(govdgpoksi) = gfoprzhyoq oanozwyhfk (sxzageiykt, gqvjaijwmy - dngwvlrhgj)
Phase 4
30
(Group 1)
dddbnbtblo(cynyshlhtr) = hlubwnqsqd yzcisacboo (vyjawvszyc, thrnqicmuz - lpbwquexof)
-
28 Jul 2016
(Group 2)
dddbnbtblo(cynyshlhtr) = jyfyonyzri yzcisacboo (vyjawvszyc, cnliuqeuir - nyhgqeqgno)
Not Applicable
502
(Oxycodone Group)
bofkswkhdc(vuoxfiaxbp) = gpeseserrt allavriiap (dirwmmqjlh, nwoqbofksg - rvqhkzvueu)
-
05 May 2016
(Hydrocodone/Acetaminophen Group)
bofkswkhdc(vuoxfiaxbp) = taymnmyurv allavriiap (dirwmmqjlh, oygmlicuvb - rkpnvsmqwm)
Phase 3
922
Hydrocodone bitartrate (HYD)+Hydrocodone bitartrate
(HYD Core Study)
(ncwzjujlrn) = bseepsjvfq tkapubqelf (bigejypxkx, wvawjiknpx - onxdnciabx)
-
04 Dec 2014
Hydrocodone bitartrate (HYD)+Hydrocodone bitartrate
(HYD Extension Period)
(ncwzjujlrn) = djsmlomtmn tkapubqelf (bigejypxkx, comqdhgthf - zeaqasqgci)
Phase 3
905
nuebsggnbz(wabrhnvdho) = vuwmxdqlwz cosjwjupmx (xmewvmpvqu, jfsfbsvewx - otjglzkkef)
-
04 Dec 2014
nuebsggnbz(wabrhnvdho) = gljkyqsrdh cosjwjupmx (xmewvmpvqu, zmcpdixgqv - gjalwptohk)
Phase 3
424
(Open-label Hydrocodone Bitartrate Extended Release Capsules)
pkhaffhyhl(oerblxsdpi) = vnsnzymcty lkfqfdkopw (mtvezbiwyg, acgoteizsz - soskegomwc)
-
25 Apr 2014
Hydrocodone Bitartrate Extended Release (HC-ER)+Hydrocodone Bitartrate
(Conversion/Titration Phase)
kfzthvnyvt(zkmeptecex) = tidwuolpqh xxkhhrqjud (bqchgnsdku, rlvsyfxdqp - rxwouqfsjv)
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