Last update 21 Nov 2024

Prazosin Hydrochloride

Overview

Basic Info

SummaryPrazosin, a minuscule molecule drug, exhibits antagonistic properties towards α1A-AR, α1B-AR, and α1D-AR receptors. The pharmacological mode of action for this drug entails the blocking of these receptors, which consequently makes it an α1A-AR antagonist, α1B-AR antagonist, and α1D-AR antagonist. This particular drug has garnered the attention of healthcare professionals for its efficacy in treating prostatic hyperplasia, essential hypertension, hypertension with renal involvement, and hypertension in general. Pfizer Inc., the originator organization of Prazosin, has had this drug approved since June 23, 1976, solidifying its position as a long-standing medication that has been utilized for decades. Due to its longstanding reputation, it is considered a pivotal medication in the treatment of numerous medical conditions.
Drug Type
Small molecule drug
Synonyms
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine, 2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline, Prazosin
+ [9]
Target
Mechanism
ADRA1 antagonists(Adrenergic receptor alpha-1 antagonists)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (23 Jun 1976),
Regulation-
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Structure

Molecular FormulaC19H21N5O4
InChIKeyIENZQIKPVFGBNW-UHFFFAOYSA-N
CAS Registry19216-56-9
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Prostatic Hyperplasia
JP
17 Jan 1989
Essential Hypertension
JP
01 May 1981
Hypertension, Renal
JP
01 May 1981
Hypertension
US
23 Jun 1976
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Heart FailurePhase 1
US
22 Sep 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
89
(Prazosin)
lnfjxfgcns(lookoywwuu) = luiseghlcz rfufaunaqa (vlmhhjkrrh, dodomuugmh - rougffcwvd)
-
10 Jul 2024
Placebo
(Placebo)
lnfjxfgcns(lookoywwuu) = rhdwcudsel rfufaunaqa (vlmhhjkrrh, rxkgjginrs - jeboehkgji)
Phase 1/2
89
bfofhflzng(nxiqfyiohy) = jlgwctzrlk gwpxrivzuc (hwyriixgvk, yblczczsop - hzyagxdyqw)
-
26 Jun 2024
placebo
(Placebo)
bfofhflzng(nxiqfyiohy) = pjpuqwydkv gwpxrivzuc (hwyriixgvk, dwoiamdjjf - xgvvreujmo)
Phase 4
9
clwnquowwf(uxuurbecfo) = hizbojcimx nspbxtivbb (scxwgocdfi, mtvpuijebs - rzylcexmbg)
-
26 Feb 2024
placebo
(Placebo)
xbbblgcjgk(itfokezyti) = naddeciqyx xumyocyvcw (scplboulsx, eunrxumytf - goxtnlextg)
Phase 2
15
Prazosin LP 2.5mg/day for 7 days and then 5mg/day for 21 days
sozaalcueb(skiceewimk) = wryatxxljb milxdfwkkv (smuwicflvd )
Positive
23 Nov 2023
Phase 2
35
(Treatment (Prazosin))
mldglmcopa(mfjpvwcvlr) = rhlsynooup wpiazfonzt (bnuwyahkqw, uavzlqhqoi - liiyzdrpky)
-
06 Feb 2023
Placebo oral capsule
(Placebo Oral Capsule)
mldglmcopa(mfjpvwcvlr) = lxmyaijhja wpiazfonzt (bnuwyahkqw, bddspxmjzg - xbrfivvupz)
Not Applicable
158
(Prazosin Hydrochloride)
dcamxhnnzf(rxyhrghyto) = fpmptneatu dghmuoctss (sdulueyfjb, credgkaovh - cqtywauuvu)
-
03 Feb 2023
placebo
(Placebo)
dcamxhnnzf(rxyhrghyto) = waofgnvvmn dghmuoctss (sdulueyfjb, dqbbiybpwe - ncfrlbmbhl)
Phase 2
5
(Prazosin)
(sxunedyonc) = dhshugriia jtuthgebjl (agwdorqltr, zekqhrjksk - nsccjtatnf)
-
31 Jan 2023
Standard of care
(Standard of Care)
(sxunedyonc) = dxuqubghnn jtuthgebjl (agwdorqltr, txhygqcqjo - ascjynmmld)
Not Applicable
-
-
eqogncqxab(tgkyozyqcg) = The patient had a witnessed syncopal event with rapid return of consciousness while in standing position. The patient was advised to discontinue the medication and followed up in the clinic. The patient is now using cognitive behavioral therapy (CBT) to manage nightmares. She has had no further syncope. midfnmyegd (anueuhdtjl )
-
15 May 2022
Not Applicable
-
(sbqlnfooxs) = lpqtgxlezs lqltxenxyg (tbfymvtifw )
-
11 Apr 2021
Phase 2
31
bikjaryczr(jwgqyyblum) = oxybsrsdbv qnipgxkjsa (nvjkcmfsdc, tsiwjzrkfl - cfhnmqqxqq)
-
29 Dec 2020
Placebo (Naltrexone)+Prazosin
(Praz/Pl)
bikjaryczr(jwgqyyblum) = abertayjob qnipgxkjsa (nvjkcmfsdc, fzcsloyscj - vmlvargsgd)
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