The efficacy and safety of taxane therapy after discontinuation of nivolumab therapy in Japanese patients with advanced or recurrent esophageal cancer:a retrospective observational study (AFTER NIVO ESO Study) - AFTER NIVO ESO study

Start Date01 Jan 2021

Sponsor / Collaborator-

NCT04290793

/ Active, not recruitingPhase 2/3IIT

Pyrotinib Combined With Epirubicin and Cyclophosphamide Followed by Docetaxel Plus Trastuzumab in Neoadjuvant Therapy of HER2-positive Early Breast Cancer: a Single-arm, Open-label, Multicenter Phase II Clinical Trial

This is a prospective, open label, single-arm study to evaluate the efficacy and safety of neoadjuvant pyrotinib in HER2+ breast cancer patients

Start Date01 Mar 2020

Sponsor / Collaborator

The Fourth Hospital of Hebei Medical University

100 Clinical Results associated with Taxane

100 Translational Medicine associated with Taxane

100 Patents (Medical) associated with Taxane

6,205

Literatures (Medical) associated with Taxane

01 Dec 2026·JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Molecular simulations of paclitaxel binding to mutant β-tubulin: insights into chemotherapy resistance

Article

Author: Centroni, Martina ; Gitari, Ebenezea ; Winter, Philip ; Vottero, Paola ; Tuszynski, Jack ; Aminpour, Maral

Paclitaxel, a cornerstone in cancer chemotherapy, stabilizes microtubules by binding to the β-tubulin taxane site. However, resistance mechanisms, often driven by β-tubulin mutations, undermine its efficacy. While such mutations are known to alter drug sensitivity, their molecular impact on paclitaxel binding remains incompletely understood. Here, we employ molecular docking, molecular dynamics (MD) simulations, and Molecular Mechanics with Generalized Born Surface Area (MM/GBSA) calculations to quantify how clinically relevant β-tubulin mutations affect paclitaxel binding affinity. Root mean square fluctuation (RMSF) analysis was used to assess local structural dynamics near the binding site. Our results show that despite minor variations in docking scores, MM/GBSA analyses revealed significant mutation-induced shifts in binding free energy, particularly for residues near the M loop, H5-H6 helices, and S9-S10 region. Complementary RMSF analysis indicated altered flexibility in several of these regions, suggesting potential disruptions to local stabilization mechanisms. Differences between single- and two-dimer simulations highlight the importance of modeling lateral protofilament contacts when evaluating microtubule-targeting agents. These findings underscore the relevance of structure-based modeling for understanding drug resistance mechanisms and informing the development of mutation-aware taxane therapies.

01 Jul 2026·BIOMATERIALS

A nanosystem targeting genomic instability and mitochondrial damage to stimulate STING pathway for synergistic immunotherapy for advanced prostate cancer

Article

Author: Shen, Meifang ; Zhang, Hanchen ; Yu, Yingjie ; Gao, Li ; Zou, Jinhan ; Li, Yajian ; Xiao, Dongming ; Wang, Haiyang ; Xiao, Haihua

Taxane-based chemotherapy and immunotherapy are standard treatments for advanced prostate cancer, yet their efficacy is often limited by drug resistance and an immunosuppressive, "cold" tumor microenvironment (TME). To address these challenges, we develop a reactive oxygen species (ROS)-responsive nanoparticle, PTX-Zn NP, for the co-delivery of paclitaxel (PTX) and zinc ions (Zn²⁺). Within tumor cells, elevated ROS triggers the release of PTX, promoting micronuclei formation and cytosolic double-stranded DNA exposure. Concurrently, Zn²⁺ amplifies cGAS-STING signaling by enhancing cGAS-DNA binding and inducing mitochondrial damage. In vitro, PTX-Zn NP suppressed tumor cell proliferation, generated ROS and micronuclei, and activated the STING pathway to promote dendritic cell maturation. In vivo, PTX-Zn NP preferentially accumulated in prostate tumors, inhibited tumor growth, and reprogrammed the "cold" TME toward a "hot" phenotype. When combined with anti-PD-L1 therapy, PTX-Zn NP significantly improved antitumor efficacy and promoted long-term immune memory. Overall, this dual-action approach provides a promising strategy to overcome both chemoresistance and immune evasion in advanced prostate cancer.

01 Mar 2026·INTERNATIONAL JOURNAL OF CANCER

Chemotherapy as a double‐edged sword: Modulation of tumor‐associated cytokine and chemokine responses in ovarian cancer

Review

Author: Shen, Bairong ; Chen, Yongxiu ; Ullah, Amin ; Shen, Yuan

Abstract:

Ovarian cancer (OC) is one of the most lethal gynecological malignancies, with high recurrence rates and chemoresistance posing significant challenges to effective treatment. Platinum‐based agents, such as cisplatin and carboplatin, along with taxanes, including paclitaxel and docetaxel, represent fundamental therapies for OC. However, the immunomodulatory effects of these agents on the tumor microenvironment are multifaceted and can be perceived as a double‐edged sword. Chemotherapeutics not only trigger cytotoxic effects but also influence the networks of pro‐ and anti‐tumor cytokines, playing a role in both treatment efficacy and resistance. We specifically examine cytokine‐mediated mechanisms underlying both platinum‐based and taxane‐based chemoresistance in OC. In this review, we comprehensively examine how platinum and taxane chemotherapy modulate cytokine signaling in OC, focusing on key mediators like interleukin (IL) 6, IL‐8, transforming growth factor‐beta, and C‐X‐C motif ligand 2 that drive survival pathways and chemoresistance. Interestingly, these agents might enhance anti‐tumor immunity via interferon‐gamma and IL‐12, revealing the potential for synergistic chemoimmunotherapy. This research provides valuable insights for addressing resistance and improving combination therapies through the analysis of the dual roles of chemotherapy in modulating cytokine dynamics in OC.

201

News (Medical) associated with Taxane

26 Feb 2026

·www.prnewswire.com

Early study results from Johnson & Johnson show promising antitumor activity with combination of pasritamig and docetaxel in advanced prostate cancer

Combination demonstrates deep PSA responses and favorable safety profile with plans to advance into Phase 3 Data highlight the potential of this first-in-class next-generation T-cell engager to expand the role of immunotherapy in prostate cancer RARITAN, N.J., Feb. 26, 2026 /PRNewswire/ -- Johnson & Johnson (NYSE:JNJ) today announced preliminary results from a Phase 1b study evaluating pasritamig (JNJ-78278343), a first-in-class bispecific T-cell engaging antibody, in combination with docetaxel in patients with metastatic castration-resistant prostate cancer. The combination demonstrated a safety profile consistent with docetaxel alone, with no new or unexpected safety signals observed. The regimen also showed clinically meaningful efficacy, including high rates of prostate-specific antigen (PSA) responses and sustained PSA reductions, supporting continued development and advancement into Phase 3 studies. The results were presented for the first time at the 2026 American Society of Clinical Oncology (ASCO) Genitourinary Cancers Symposium (Abstract #171).1 Pasritamig is designed to engage the immune system through a novel mechanism of action, binding CD3 on T cells and human kallikrein 2 (KLK2). KLK2 is a novel, highly specific prostate cancer target with minimal expression outside prostate tissue. By both activating and directing T cells to KLK2-expressing tumor cells, pasritamig enables targeted immune engagement. This differentiated, prostate-specific approach was intentionally built to focus immune activity on prostate cancer cells, which may help limit effects on healthy tissue, and supports administration in a doctor's office rather than hospital setting. "These data represent an important step forward for patients with advanced prostate cancer," said Professor Shahneen Sandhu,* M.D., Ph.D., MBBS, FRACP, Associate Professor, Consultant Medical Oncologist and researcher at Peter MacCallum Cancer Centre, and study investigator. "In a disease where outcomes remain poor for many patients, seeing encouraging clinical activity alongside a favorable safety profile in combination with docetaxel reinforces the potential of this approach and supports further clinical development." "Based on these findings, we are increasingly confident in the potential of pasritamig to meaningfully improve outcomes for people with prostate cancer," said Charles Drake, M.D., Ph.D., Vice President, Prostate Cancer and Cross Cancer Immuno-Oncology, Johnson & Johnson. "The ability to combine pasritamig with docetaxel, where prior approaches in the field have fallen short, gives us a strong foundation for Phase 3 development. What we're seeing with this combination, including deep and durable PSA responses, underscores the promise of this combination immunotherapy approach and our commitment to advancing innovation that can make a difference for patients." Detailed Study Results In the study, pasritamig was evaluated in combination with docetaxel in an outpatient setting in patients with metastatic castration-resistant prostate cancer whose disease had progressed following androgen receptor pathway inhibitor therapy. Approximately half of the patients (45 percent) had received at least one prior taxane-based regimen. The primary endpoint was safety and identification of the recommended regimen for further development in Phase 2/3 studies, with secondary and exploratory endpoints assessing clinical activity, including PSA response rates.1 As of December 9, 2025, 51 patients had received pasritamig plus docetaxel, including patients who were pretreated with a median of three prior therapies (range, 1-9). Reductions of 50 percent or greater in PSA levels were achieved in 64.7 percent of patients overall and in 75.0 percent of taxane-naïve patients. Reductions of 90 percent or greater in PSA levels were achieved in 39.2 percent of patients overall and 53.6 percent of taxane-naïve patients. Among taxane-naïve patients with bone-only disease, confirmed PSA reductions of 50 percent or greater and 90 percent or greater were observed in 88.2 percent and 76.5 percent of patients, respectively. Patients were able to continue pasritamig beyond docetaxel discontinuation. Those patients received a median of six docetaxel doses every three weeks and eight pasritamig doses every six weeks, supporting the potential for sustained disease control over time.1 The safety profile of pasritamig plus docetaxel was consistent with the known safety profile of docetaxel in metastatic castration-resistant prostate cancer. The most common treatment-related adverse events (TRAEs) occurring in at least 20 percent of patients included fatigue (60.8 percent), alopecia (41.2 percent), diarrhea and nausea (31.4 percent each), peripheral edema (27.5 percent), peripheral sensory neuropathy (25.5 percent) and dysgeusia (23.5 percent). Pasritamig-related adverse events occurring in at least 10 percent of patients were fatigue (33.3 percent) and non-chronic diarrhea (11.8 percent). Grade 3 or higher TRAEs attributed to docetaxel were observed in 29.4 percent of patients, compared with only two percent attributed to pasritamig. No patients experienced cytokine release syndrome of any grade or treatment-related deaths.1 Two ongoing Phase 3 studies are evaluating pasritamig in the metastatic castration-resistant prostate cancer setting. KLK2-comPAS (NCT07164443) is evaluating pasritamig as monotherapy, and KLK2-PASenger (NCT07225946) is evaluating pasritamig in combination with docetaxel.2,3 Beyond these Phase 3 studies, pasritamig is also being evaluated in earlier-phase combination studies. Pasritamig monotherapy has received Breakthrough Therapy Designation in China and Fast Track designation from the U.S. Food and Drug Administration, supporting its continued clinical development. About the Study The Phase 1b study (NCT05818683) is an open-label trial evaluating the safety and clinical activity of pasritamig in combination with docetaxel in patients with metastatic castration-resistant prostate cancer (mCRPC) whose disease has progressed following treatment with an androgen receptor pathway inhibitor. The primary objective is to determine the recommended regimen for further development based on safety, with secondary and exploratory endpoints assessing clinical activity. Pasritamig was administered intravenously every six weeks, with initial step-up doses given during the first treatment cycle, in combination with docetaxel administered intravenously every three weeks. Treatment was delivered in an outpatient setting. Corticosteroids were used only as standard premedication for docetaxel, and hematopoietic growth factor support was permitted as needed.4 About Pasritamig (JNJ-78278343) Pasritamig (JNJ-78278343) is an investigational T-cell-redirecting bispecific antibody (bsAb) targeting human kallikrein 2 (KLK2) on prostate cancer cells and CD3 receptor complexes on T cells, leveraging the body's immune system to selectively target and eliminate cancer cells. This innovative approach is being evaluated in pretreated patients with metastatic castration-resistant prostate cancer (mCRPC), a patient population with limited treatment options. About Metastatic Castration-Resistant Prostate Cancer (mCRPC) Metastatic castration-resistant prostate cancer (mCRPC) is a challenging and aggressive stage of prostate cancer where the disease progresses despite androgen deprivation therapy.5 Patients often experience metastasis to bones and lymph nodes, leading to poor outcomes and limited treatment options, including chemotherapy and second-line hormone therapies.6 The median overall survival ranges from 13.5 to 31.6 months depending on the site of metastasis, with a typical range of 15 to 36 months across the broader population.7,8 Survival rates can vary significantly depending on factors such as prior treatment history, disease burden, and response to therapy. The need for more effective treatments is critical, as the disease continues to impact a large number of men globally, with metastatic castration-resistant prostate cancer (mCRPC) being responsible for a substantial number of prostate cancer-related deaths. About Johnson & Johnson At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for humanity. Learn more at or at . Follow us at @JNJInnovMed. Cautions Concerning Forward-Looking Statements This press release contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act of 1995 regarding product development and the potential benefits and treatment impact of pasritamig (JNJ-78278343). The reader is cautioned not to rely on these forward-looking statements. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or known or unknown risks or uncertainties materialize, actual results could vary materially from the expectations and projections of Johnson & Johnson. Risks and uncertainties include, but are not limited to: challenges and uncertainties inherent in product research and development, including the uncertainty of clinical success and of obtaining regulatory approvals; uncertainty of commercial success; manufacturing difficulties and delays; competition, including technological advances, new products and patents attained by competitors; challenges to patents; product efficacy or safety concerns resulting in product recalls or regulatory action; changes in behavior and spending patterns of purchasers of health care products and services; changes to applicable laws and regulations, including global health care reforms; and trends toward health care cost containment. A further list and descriptions of these risks, uncertainties and other factors can be found in Johnson & Johnson's most recent Annual Report on Form 10-K, including in the sections captioned "Cautionary Note Regarding Forward-Looking Statements" and "Item 1A. Risk Factors," and in Johnson & Johnson's subsequent Quarterly Reports on Form 10-Q and other filings with the Securities and Exchange Commission. Copies of these filings are available online at , or on request from Johnson & Johnson. Johnson & Johnson does not undertake to update any forward-looking statement as a result of new information or future events or developments. *Professor Shahneen Sandhu, M.D., Ph.D., MBBS, FRACP has provided consulting, advisory, and speaking services to Johnson & Johnson; she has not been paid for any media work. Source: Johnson & Johnson SOURCE Johnson & Johnson 21% more press release views with Request a Demo

Clinical ResultPhase 3ASCOFast TrackImmunotherapy

26 Feb 2026

·www.fiercebiotech.com

Bristol Myers\' $800M ADC hits primary survival endpoints in phase 3 breast cancer trial

In a Chinese phase 3 trial of a Bristol Myers Squibb antibody-drug conjugate, progression-free and overall survival were significantly better on izalontamab brengitecan than on chemotherapy.\n A Chinese phase 3 trial of Bristol Myers Squibb’s antibody-drug conjugate has hit its dual primary survival endpoints, providing further validation of the Big Pharma\'s $800 million bet on the candidate.BMS paid SystImmune $800 million upfront in 2023 for ex-China rights to the EGFR×HER3 bispecific ADC, izalontamab brengitecan (iza-bren). The deal, which marked BMS’ entry into the ADC space, covered a drug candidate with the potential to tackle cancer cell proliferation and survival by blocking EGFR and HER3 while simultaneously delivering a cytotoxic payload to tumor cells. Since then, phase 3 studies run by SystImmune’s parent company, Sichuan Biokin Pharmaceutical, have hit primary endpoints, leading to filings for approval in forms of esophageal and throat cancers in China. Biokin reported a third late-stage win Thursday.The latest data come from a phase 3 trial that gave iza-bren to people with unresectable locally advanced or metastatic triple-negative breast cancer (TNBC). Participants’ cancers had previously progressed after taxane therapy. TNBC patients who had previously received certain other drugs, including ADCs, were excluded from the trial. At a prespecified interim analysis, progression-free and overall survival were significantly better on iza-bren than on physician’s choice of chemotherapy, achieving the trial’s dual primary endpoints. No data from the trial are publicly available, with the companies holding the results back for an upcoming medical meeting. The implications of the phase 3 victory for BMS are unclear. While Biokin targeted the post-taxane population, BMS’ phase 2/3 TNBC trial is enrolling first-line patients who are ineligible for anti-PD-1/L1 checkpoint inhibitors such as Merck & Co.’s Keytruda. EGFR and HER3 are often overexpressed in TNBC, an aggressive tumor that lacks the receptors and proteins that enable treatment of other breast cancers. Merck is targeting some similar biology with its Daiichi Sankyo-partnered, HER3-directed ADC patritumab deruxtecan. The Big Pharma began a phase 3 study of the drug candidate in hormone receptor-positive, HER2-negative unresectable locally advanced or metastatic breast cancer last year. BioNTech started a phase 1/2 trial of an EGFR×HER3 bispecific ADC in advanced solid tumor patients in August.

$Bristol Myers\' $800M ADC hits primary survival endpoints in phase 3 breast cancer trial$

Phase 3ADCClinical ResultClinical Trial Termination

26 Feb 2026

·www.biospace.com

SystImmune and Bristol Myers Squibb Highlight Positive Phase III Interim Topline Results for izalontamab brengitecan (Iza-bren) in Previously Treated Unresectable Locally Advanced or Metastatic Triple-Negative Breast Cancer

Izalontamab brengitecan (Iza-bren) met its dual primary endpoints of progression free survival (“PFS”) and overall survival (“OS”) in an interim analysis of a Phase 3 trial (NCT06382142) conducted in China BL-B01D1-307 is the third Phase III study in which iza-bren has achieved its primary endpoint(s) REDMOND, Wash. & PRINCETON, N.J.--(BUSINESS WIRE)-- $BMY #Patients -- SystImmune, Inc . (SystImmune), a clinical-stage biotechnology company, and Bristol Myers Squibb (NYSE: BMY) today announced that SystImmune’s parent company, Sichuan Biokin Pharmaceutical Co., Ltd. (Biokin), reported positive topline results from a pre-specified interim analysis of a Phase III study (BL-B01D1-307) evaluating izalontamab brengitecan (iza-bren), an EGFR×HER3 bispecific antibody-drug conjugate (ADC), in patients with unresectable locally advanced or metastatic triple-negative breast cancer (TNBC) whose disease progressed following prior taxane therapy. In the pre-specified interim analysis, topline results showed that iza-bren demonstrated statistically significant and clinically meaningful improvement in both progression-free survival (PFS) and overall survival (OS) compared to chemotherapy of physician’s choice, meeting both dual primary endpoints. This Phase III study represents the third Phase III trial in which iza-bren has achieved its primary endpoint(s). It is the first bispecific ADC in a Phase III study to report dual positive PFS/OS results in the treatment of triple-negative breast cancer. “Patients with advanced triple-negative breast cancer who progress after standard therapies face an urgent need for more effective options,” said Dr. Yi Zhu, Chief Executive Officer of Biokin “These topline results further strengthen our confidence in iza-bren’s potential to deliver meaningful clinical benefit across multiple cancers.” “These results underscore the potential of bispecific ADC technology targeting both EGFR and HER3 to meaningfully change outcomes in difficult‑to‑treat cancers,” said Cristian Massacesi , Executive Vice President, Chief Medical Officer and Head of Development at Bristol Myers Squibb. “We look forward to advancing the science and development of ADCs, with the hope of uncovering new options for people living with cancer.” These data will be presented at an upcoming medical meeting. The BL-B01D1-307 study is sponsored by SystImmune’s parent company, Sichuan Biokin Pharmaceutical Co., Ltd. (Biokin), in Mainland China. Outside of China, iza-bren is jointly developed by SystImmune and Bristol Myers Squibb (BMS) under a collaboration and exclusive license agreement. The Center for Drug Evaluation (CDE) under China’s National Medical Products Administration (NMPA) granted Breakthrough Therapy Designation (BTD) to iza-bren for the treatment of seven indications, and the U.S. FDA has granted BTD to iza-bren for previously treated NSCLC patients with an EGFR mutation. The New Drug Applications (NDAs) for two indications of iza-bren, for the treatment of locally advanced or metastatic nasopharyngeal carcinoma and for the treatment of recurrent or metastatic esophageal squamous cell carcinoma, have been accepted by the CDE and included in the priority review process. About BL-B01D1-307 BL-B01D1-307 is a Phase III, randomized, open-label, multi-center clinical study in China, evaluating iza-bren in patients with unresectable locally advanced or metastatic triple-negative breast cancer whose disease progressed following prior taxane therapy. The study includes dual primary endpoints of progression-free survival (PFS) and overall survival (OS). For more detailed information, please visit clinical.trials.gov (NCT06382142). About iza-bren SystImmune, in collaboration with BMS outside of China, is developing iza-bren (BL-B01D1), a bispecific antibody-drug conjugate (ADC) that targets both EGFR and HER3, which are highly expressed in various epithelial cancers and are known to be associated with cancer cell proliferation and survival. Iza-bren's dual mechanism of action blocks EGFR and HER3 signals to cancer cells, reducing proliferation and survival signals. In addition, upon antibody mediated internalization, iza-bren's therapeutic novel Topo1i payload is released causing cytotoxic stress that leads to cancer cell death. About SystImmune SystImmune is a clinical-stage biopharmaceutical company located in Redmond, WA. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has several assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials, SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discovery or IND-enabling stages, representing cutting-edge biologics development. About Bristol Myers Squibb Bristol Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases. For more information about Bristol Myers Squibb, visit us at BMS.com or follow us on LinkedIn , X , YouTube , Facebook and Instagram . SystImmune Forward-Looking Statements This press release contains forward-looking statements, including statements regarding the potential clinical benefits of iza-bren, the timing and outcomes of regulatory interactions, and the future development and commercialization of iza-bren. Forward-looking statements are subject to risks and uncertainties that may cause actual results to differ materially. SystImmune undertakes no obligation to update any forward-looking statements contained herein, except as required by law. Bristol Myers Squibb Cautionary Statement Regarding Forward-Looking Statements This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 regarding, among other things, the research, development and commercialization of pharmaceutical products. All statements that are not statements of historical facts are, or may be deemed to be, forward-looking statements. Such forward-looking statements are based on current expectations and projections about Bristol Myers Squibb’s future financial results, goals, plans and objectives and involve inherent risks, assumptions and uncertainties, including internal or external factors that could delay, divert or change any of them in the next several years, that are difficult to predict, may be beyond our control and could cause our future financial results, goals, plans and objectives to differ materially from those expressed in, or implied by, the statements. These risks, assumptions, uncertainties and other factors include, among others, that the expected benefits of, and opportunities related to, the collaboration with SystImmune may not be realized by Bristol Myers Squibb or may take longer to realize than anticipated, that iza-bren (BL-B01D1) may not receive regulatory approval for the indications described in this release in the currently anticipated timeline or at all, any marketing approvals, if granted, may have significant limitations on their use and, if approved, whether such product candidates will be commercially successful. No forward-looking statement can be guaranteed. Forward-looking statements in this press release should be evaluated together with the many risks and uncertainties that affect Bristol Myers Squibb’s business and market, particularly those identified in the cautionary statement and risk factors discussion in Bristol Myers Squibb’s Annual Report on Form 10-K for the year ended December 31, 2025, as updated by our subsequent Quarterly Reports on Form 10-Q, Current Reports on Form 8-K and other filings with the Securities and Exchange Commission. The forward-looking statements included in this document are made only as of the date of this document and except as otherwise required by applicable law, Bristol Myers Squibb undertakes no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events, changed circumstances or otherwise. corporatefinancial-news Contacts Bristol Myers Squibb Media Inquiries: media@bms.com Investors: investor.relations@bms.com Media Contact SystImmune, Inc. media@systimmune.com

Phase 3License out/inPriority ReviewBreakthrough TherapyClinical Result

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Indication	Highest Phase	Country/Location	Organization	Date
Breast Cancer	Phase 3	Germany	Martin-Luther-Universität Halle-Wittenberg	31 Jan 2002
Brain metastases	Phase 2	China	Second Affiliated Hospital of Zhengzhou University	01 Oct 2021
Triple Negative Breast Cancer	Phase 2	Russia	Russian Academy of Medical Sciences	31 Aug 2011
HER2 Positive Breast Cancer	Phase 2	Australia	Hoffmann-La Roche, Inc.	13 Aug 2009
HER2 Positive Breast Cancer	Phase 2	Spain	Hoffmann-La Roche, Inc.	13 Aug 2009
HER2 Positive Breast Cancer	Phase 2	Sweden	Hoffmann-La Roche, Inc.	13 Aug 2009
HER2 Positive Breast Cancer	Phase 2	United Kingdom	Hoffmann-La Roche, Inc.	13 Aug 2009
Fallopian Tube Carcinoma	Phase 2	China	Shanghai Jiao Tong University	30 Apr 2009
Fallopian Tube Carcinoma	Phase 2	China	Fudan University	30 Apr 2009
Follicular Adenocarcinoma	Phase 2	China	Shanghai Jiao Tong University	30 Apr 2009

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


SABCS2023	Not Applicable	Triple Negative Breast Cancer Neoadjuvant HER2 expression	143	Anthracycline and Taxane-based chemotherapy	xkiedlaowi(gkaxnycknu) = qkhhnxfrqa woisjjyuca (dlhwczdveo ) View more	-	01 Mar 2023
				Anthracycline and Taxane-based chemotherapy + Carboplatin	legduahxbe(ydgawwhcey) = xdcpzeamvs uzptkmpljl (xamqnktyby ) View more
Pubmed \| Breast	Not Applicable	HER2-negative breast cancer First line HER2-negative \| hormone-receptor positive	1,057	Taxanes without bevacizumab	mfhsolaqjy(ggkaiwfaec): HZR = 1.3 View more	Negative	01 Oct 2022
				Other chemotherapies
ASTRO2017	Not Applicable	Esophageal Carcinoma	-	Platinum-based/5-fluorouracil (PF)	andeqznrkh(dqjesmlabf) = bnrlxiyeze kltdaradrd (llqhxongar ) View more	-	01 Oct 2017
				Taxane-based/5-fluorouracil (TF)	andeqznrkh(dqjesmlabf) = gplghlgfor kltdaradrd (llqhxongar ) View more
ASTRO2014	Not Applicable	Uterine Serous Carcinoma	-	Taxane (UPSC)	amufidxdrz(ztratlxltr) = lqpjhioxwn lqyxjbrkco (obaycpmcgf, 3 - 16)	-	01 Sep 2014
				Taxane (CS)	amufidxdrz(ztratlxltr) = hkiwvbqptg lqyxjbrkco (obaycpmcgf, 2 - 30)
Pubmed \| Clin Cancer Res	Phase 1	Neoplasms	30	Carboplatin	jdretcybfx(ryccltsldj) = bswxaawkus cecmrbrspm (jgrhierqkb )	-	15 Jan 2006

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