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Last update 16 May 2025
GC-008T
Last update 16 May 2025
Overview
Basic Info
Drug Type Autologous CAR-T |
Synonyms CRISPR-engineered CAR-T cells - Gracell Biotechnology, GC 008T, GC008T |
Target |
Action inhibitors |
Mechanism MSLN inhibitors(Mesothelin inhibitors), PD-1 inhibitors(Programmed cell death protein 1 inhibitors), Gene transference(Gene transference) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
License Organization- |
Drug Highest PhasePendingPhase 1 |
First Approval Date- |
Regulation- |
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Related
2
Clinical Trials associated with GC-008TNCT03747965
Phase I Study of CRISPR-Cas9 Mediated PD-1 Gene-knocked Out Mesothelin-directed CAR-T Cells With the Conditioning Regimen of Paclitaxel and Cyclophosphamide in Mesothelin Positive Multiple Solid Tumors
NCT03545815
Phase I Study to Evaluate Treatment of CRISPR-Cas9 Mediated PD-1 and TCR Gene-knocked Out Chimeric Antigen Receptor (CAR) T Cells in Patients With Mesothelin Positive Multiple Solid Tumors.
100 Clinical Results associated with GC-008T
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100 Translational Medicine associated with GC-008T
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100 Patents (Medical) associated with GC-008T
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100 Deals associated with GC-008T
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Solid tumor | Phase 1 | China | 13 Nov 2018 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Phase 1 | Mesothelin positive Solid Tumors MSLN Positive | 9 | mwdzwwbkcy(qzkptxmtxb) = two patients in cohort 3 developed grade 1 CRS with fever and rash owruxbgzdb (goeiwjzgmi ) View more | Positive | 29 May 2020 |
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