Last update 23 Dec 2025

Amentoflavone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
穗花杉双黄酮
Target
ASICs x CLPP x GABAA receptor x TRPV1
Action
modulators, inhibitors, negative allosteric modulator
Mechanism
Acid-sensing (proton-gated) ion channels (ASICs) modulators, CLPP inhibitors(caseinolytic mitochondrial matrix peptidase proteolytic subunit inhibitors), GABAA receptor negative allosteric modulator(Gamma-aminobutyric acid A receptor negative allosteric modulator)
Therapeutic Areas
NeoplasmsInfectious DiseasesNervous System Diseases+ [3]
Active Indication
Neurodegenerative DiseasesMRSA - Methicillin resistant Staphylococcus aureus infectionPancreatic Cancer+ [1]
Inactive Indication-
Originator Organization
The University of Sydney
Active Organization
Dalian Medical UniversityDalian Medical UniversityUniversidade Estadual Do CearaUniversidade Estadual Do CearaChangchun University of Chinese MedicineChangchun University of Chinese Medicine
Inactive Organization-
License Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-

Related

100 Clinical Results associated with Amentoflavone
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100 Translational Medicine associated with Amentoflavone
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100 Patents (Medical) associated with Amentoflavone
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100 Deals associated with Amentoflavone
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Neurodegenerative DiseasesPreclinical--17 Nov 2025
MRSA - Methicillin resistant Staphylococcus aureus infectionPreclinical
China
Changchun University of Chinese MedicineChangchun University of Chinese Medicine
22 Oct 2025
Pancreatic CancerPreclinical
China
Dalian Medical UniversityDalian Medical University
14 Oct 2025
PainPreclinical
Brazil
Universidade Estadual Do CearaUniversidade Estadual Do Ceara
01 Oct 2025
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Clinical Result

Indication
Phase
Evaluation
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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