Effects of educational technology on the knowledge, attitude and practice of caregivers of beed-bed children and adolescents at home: an almost experimental study

Start Date15 Jan 2024

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Universidade Estadual Do Ceara

100 Clinical Results associated with Universidade Estadual Do Ceara

0 Patents (Medical) associated with Universidade Estadual Do Ceara

9,822

Literatures (Medical) associated with Universidade Estadual Do Ceara

01 Jul 2025·Journal of Molecular Structure

A phenolic ether 2-methoxy-carvacrol isolated from Rhabdocaulon lavanduloides (Benth) Epling. (Lamiaceae): New crystal structure, Hirshfeld surface, quantum chemical calculation, anxiolytic and anticonvulsant potential in zebrafish, and molecular docking of GABAA receptor

Author: Rebelo, Ricardo Andrade ; Begnini, Ieda Maria ; Silva dos Santos, Helcio ; de Menezes, Ramon Roseo Paula Pessoa Bezerra ; Magalhaes, Emanuel Paula ; Barreto, Antonio Cesar Honorato ; Deschamps, Cicero ; Marinho, Emmanuel Silva ; Mendes, Francisco Rogenio da Silva ; Ayala, Alejandro Pedro ; Boyen, Adriana Daniel ; Amancio Ferreira, Maria Kueirislene ; Amaral, Wanderlei do ; da Silva, Luiz Everson ; de Menezes, Jane Eire Silva Alencar ; Rocha, Moises Bruno Marinho ; Marinho, Marcia Machado ; Teixeira, Alexandre Magno Rodrigues

The drugs that treat anxiety disorder have variable efficacy and associated side effects.This study evaluated the anxiolytic and anticonvulsant potential of natural product 2-methoxy-carvacrol isolated from Rhabdocaulon lavanduloides, its resp. mechanism of action in adult zebrafish (ZFa), in addition to an in silico.Each animal (n=6/group) was treated i.p. (i.p.; 20μL) with the natural product (4, 20 and 40 mg/Kg) and with the vehicle (DMSO 3%; 20μL), being submitted to the tests of locomotor activity and 96 h acute toxicity.The study showed that 2-methoxy-carvacrol was not toxic in the assessment of locomotion behavior of adult zebrafish at all doses evaluated.The two highest doses displayed anxiolytic effect, and when examining the mechanism of action, it was found that this effect is neuromodulated by the GABAergic pathway.Furthermore, the sample was able to reverse the convulsive behavior of the animals in the early stage of anal. (Stage I).Mol. docking simulations indicate that 2-methoxy-carvacrol has a distinct affinity from that of the co-crystallized inhibitor, suggesting allosteric activity.Furthermore, its interactions with the GABAAR receptor are like those of DZP, highlighting potential anxiolytic effects.The pharmacokinetic test showed that PAMPA suggests high cellular permeability for potential intestinal absorption.

01 Jul 2025·Microbial Pathogenesis

Evaluation of the intrinsic antibacterial and antibiotic potentiating activity against antibiotic resistance in Staphylococcus aureus and inhibition of the NorA and MepA efflux pumps by a hydrazone derivative of isoniazid

Article

Author: Guedes, Jesyka Macedo ; de Freitas, Thiago Sampaio ; de Lima, Luciene Ferreira ; Melo Coutinho, Henrique Douglas ; Rodrigues Teixeira, Alexandre Magno ; Silva Pereira, Raimundo Luiz ; de Oliveira, Victor Moreira ; Marinho, Márcia Machado ; Dos Santos, Hélcio Silva ; Costa, Wégila Davi ; Marinho, Emmanuel Silva ; de Souza, Mikael Amaro ; Maria Lima Dias, Jaiza ; Rocha, Janaina Esmeraldo

Hydrazones are organic compounds with promising antimicrobial properties, particularly in the fight against resistant microorganisms. The aim of this study was to synthesize and evaluate the antibacterial activity of the hydrazone derivative of isoniazid N'-[[4-({[(pyridin-4-yl)formamido]imino] methyl)phenyl]methylidene]pyridine-4 carbohydrazide (BISHDZHI) against Staphylococcus aureus overexpressing NorA and MepA efflux pumps. The broth microdilution methodology was used in the microbiological tests to evaluate the antibacterial potential of the BISHDZHI compound and its ability to inhibit efflux pump resistance mechanisms. To elucidate the mechanism of action, molecular docking simulations were conducted to assess the binding affinity of BISHDZHI to the NorA and MepA efflux pumps. Minimum inhibitory concentration (MIC) tests showed that BISHDZHI in association with norfloxacin moderately reduced the MIC of the antibiotic, indicating the enhancement of its efficacy. However, an antagonistic effect was observed in combination with ethidium bromide, suggesting that the compound does not directly inhibit bacterial efflux pumps, but may act on other intracellular targets, such as the enzyme topoisomerase IV. The docking studies revealed strong interactions between BISHDZHI and key amino acid residues within the efflux pumps, particularly Tyr225, Val302, and Phe306 in NorA and Leu59, Phe280, and Tyr276 in MepA. The docking scores indicated favorable binding energies, suggesting potential inhibitory effects on efflux activity. This study highlights the potential of the hydrazone BISHDZHI as a promising candidate for treating infections caused by the bacterium Staphylococcus aureus.

01 Jun 2025·The Journal of Steroid Biochemistry and Molecular Biology

Modifying-antibiotic action of Hecogenin Acetate as an alternative to combat bacterial infections

Article

Author: Filho, José Maria Barbosa ; Felix, Franceildo Jorge ; Araújo, Nara Juliana Santos ; Paulo, Cícera Laura Roque ; Da Silva, Ana Raquel Pereira ; Coutinho, Henrique Douglas Melo ; Do Socorro Costa, Maria ; Andrade-Pinheiro, Jacqueline Cosmo ; Silva, Camila Aparecida Pereira

Bacterial infections are pathologies with specific morbidity and mortality that disrupt a high level of care in health systems. These diseases are treated using antibacterial drugs. Antibiotics are drugs that act by inhibiting bacterial growth or promoting the death of microorganisms. Their indiscriminate use is considered one of the main factors in the emergence of bacterial resistance, which is currently a major public health problem. Among the alternatives for controlling resistance is the search for new drugs, which are mainly based on the use of natural products with known bioactivity. These include Hecogenin Acetate, a sapogenin with significant anti-inflammatory, antifungal and antimicrobial activity. In order to evaluate HA's ability to modulate the antimicrobial activity of commonly used antibiotics, tests were carried out using the microdilution technique with bacterial strains of clinical interest. Hecogenin Acetate was found to be predominantly potentiating the antibiotic action, demonstrating that the association of Hecogenin Acetate with antibiotics presents a potential for innovative treatment, requiring further evaluation for the probable development of new antibacterial drugs. This action could classify the natural product as an important alternative for the pharmaceutical industry in the treatment of bacterial infections, reducing bacterial resistance and increasing the range of therapeutic possibilities, indirectly contributing to improvements in the public health scenario.

100 Deals associated with Universidade Estadual Do Ceara

100 Translational Medicine associated with Universidade Estadual Do Ceara

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