Last update 20 Mar 2025

ONC-206

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Action
agonists, antagonists
Mechanism
CLPP agonists(caseinolytic mitochondrial matrix peptidase proteolytic subunit agonists), D2 receptor antagonists(Dopamine D2 receptor antagonists), D3 receptor antagonists(Dopamine D3 receptor antagonists)
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC23H22F2N4O
InChIKeyITMGVSSHWMTJRR-UHFFFAOYSA-N
CAS Registry1638178-87-6

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Choroid Plexus NeoplasmsPhase 1
United States
26 Oct 2020
Diffuse AstrocytomaPhase 1
United States
26 Oct 2020
Diffuse midline glioma, point mutation K27M in histone H3Phase 1
United States
26 Oct 2020
EpendymomaPhase 1
United States
26 Oct 2020
GlioblastomaPhase 1
United States
26 Oct 2020
GliosarcomaPhase 1
United States
26 Oct 2020
MedulloblastomaPhase 1
United States
26 Oct 2020
MeningiomaPhase 1
United States
26 Oct 2020
PinealomaPhase 1
United States
26 Oct 2020
GangliogliomaDiscovery
United States
26 Oct 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
Neoplasms
DRD2+ | DRD5-
-
inuwiihqpr(cqlydjbjqh) = wzzedbexxn nradzuwbsi (xmbsviovyh )
-
11 Nov 2019
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Clinical Trial

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Approval

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Regulation

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