Last update 21 Nov 2024

Rocbrutinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
+ [6]
Target
Mechanism
BTK inhibitors(Tyrosine-protein kinase BTK inhibitors)
Inactive Indication-
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationBreakthrough Therapy (CN)
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Structure

Molecular FormulaC42H51N9O5
InChIKeyOYJVFTNYBWVQHA-SANMLTNESA-N
CAS Registry2485861-07-0

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Mantle cell lymphoma refractoryPhase 2
CN
21 Feb 2023
Chronic Lymphocytic LeukemiaPhase 1
US
19 Jul 2021
Diffuse Large B-Cell LymphomaPhase 1
US
19 Jul 2021
Follicular LymphomaPhase 1
US
19 Jul 2021
Hairy Cell LeukemiaPhase 1
US
19 Jul 2021
Mantle-Cell LymphomaPhase 1
US
19 Jul 2021
Marginal Zone B-Cell LymphomaPhase 1
US
19 Jul 2021
Small Lymphocytic LymphomaPhase 1
US
19 Jul 2021
Waldenstrom MacroglobulinemiaPhase 1
US
19 Jul 2021
B-cell lymphoma refractoryPhase 1
CN
06 Jul 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
ymypqhxhjm(mxclivdbpx) = TEAE seen in >20% of pts included nausea, constipation, headache, abdominal pain, cough, diarrhea, dizziness, fatigue, petechiae; of those, grade 3 or higher AE included constipation and fatigue in 1 pt each. Serious AEs (scrotal infection, pneumonia, middle ear inflammation, altered state of consciousness) were seen in 4 pts, with dose interruption in one. No atrial fibrillation/flutter has been reported. No Grade 3 or higher hypertension has been reported in this GM cohort. Grade 3 or higher infection (scrotal infection and pneumonia) and neutropenia are seen in 3 pts (scrotal infection, neutropenia, neutropenia and pneumonia). 1 pt experienced low-grade bleeding and 4 pts experienced low-grade bruising. ubejvgmfno (dfzdcwnaqa )
-
09 Dec 2024
Not Applicable
-
mgnpcqcfvk(wgvpflbtmy) = ualfnbwese olgasaefri (wmwgqutcct )
-
08 Dec 2024
mgnpcqcfvk(wgvpflbtmy) = mgvsuoirti olgasaefri (wmwgqutcct )
Not Applicable
-
sdtdetvkxn(oxijnfinqo) = lung infection, not related to rocbrutinib scfultihyr (eyugsvuyiu )
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08 Dec 2024
Not Applicable
-
qvdghljvvj(chwgobvzdj) = 26.7% skjobxtscx (dmkcwkjfkh )
-
07 Dec 2024
Phase 1
68
(vgszrllkxh) = psugqfeueb lbsavebeys (kknekynorz )
-
11 Dec 2023
Phase 1
-
ofjpkhviqv(snlsjabjfj) = fewkdoiazr yhxfqzkqht (miauqxfrns )
-
10 Dec 2023
Phase 1
43
(sgnfpkonym) = dnjotvwqtd qnwtjgtdtr (vvtyvqaana )
-
09 Dec 2023
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Regulation

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