Delving into the Latest Updates on Chlordiazepoxide Hydrochloride/Clidinium Bromide with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Librax

Target

GABAA receptor

Action

agonists

Mechanism

GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists)

Therapeutic Areas

Digestive System Disorders

Active Indication

EnterocolitisIrritable Bowel SyndromePeptic Ulcer

Inactive Indication-

Originator Organization

Bausch Health Americas, Inc.

Active Organization

Bausch Health US LLC

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

United States (01 Sep 1966),

EnterocolitisIrritable Bowel SyndromePeptic Ulcer

Regulation-

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Structure/Sequence

Molecular FormulaC16H15Cl2N3O

InChIKeyDMLFJMQTNDSRFU-UHFFFAOYSA-N

CAS Registry438-41-5

View All Structures (2)

Non-cardiac chest pain is a common clinical problem encountered in our practice but at present, the results of treatments are unsatisfactory. The pathogenesis remains unknown but altered motility of the esophagus and psychological factors including anxiety have been implicated as important factors. Reports of the single use of anticholinergic drugs and anxiolytics have yielded conflicting results, has been demonstrated to yield marginal or of no value. However the use of the combination therapy, especially with a double blind fashion have not been reported. On that basis, we propose to use a combination of anti-cholinergic and tranquilliser for the symptomatic treatment of non-cardiac chest pain. The aim of this study is to evaluate the efficacy of combination therapy of anti-cholinergic and anxiolytic drugs in the treatment of non-cardiac chest pain.

Start Date01 Jun 2002

Sponsor / Collaborator

Hospital Authority (Hong Kong)

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100 Clinical Results associated with Chlordiazepoxide Hydrochloride/Clidinium Bromide

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100 Translational Medicine associated with Chlordiazepoxide Hydrochloride/Clidinium Bromide

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100 Patents (Medical) associated with Chlordiazepoxide Hydrochloride/Clidinium Bromide

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18

Literatures (Medical) associated with Chlordiazepoxide Hydrochloride/Clidinium Bromide

01 Oct 2013·Indian Journal of Clinical Biochemistry

The Impact of Digestive and Colon Drugs on the Human Hormones Profile

Article

Author: Ahmed, Hanaa H ; Abd-Rabou, Ahmed A ; Eskander, Emad F

Hormones play an important role in the digestive system. The main hormones that control digestion are gastrin, secretin, and cholecystokinin. Herein, the current study is concerned with assessing the effect of spasmo canulase and librax drugs on the human hormones profile. Blood samples were withdrawn from adult patients to measure serum FSH, E2, LH, prolactin, progesterone, DHEAS, testosterone, TSH, T3, T4, fasting insulin, and cortisol. All hormone concentrations were determined quantitatively using ELISA procedure. Intriguingly, the present study showed putative changes including thyroid and sex hormonal profiles. Eventually, we concluded that the prospective study could be important in drug dose optimization and providing new medical guidelines to avoid side effects that could harm patients.

01 Sep 2002·Saudi medical journalQ4 · MEDICINE

Spasmocanulase in irritable bowel syndrome.

Q4 · MEDICINE

Article

Author: Ghandour, Zuhal M ; Mohamed, Abdelrahman E ; Al-Karawi, Mohamed A

OBJECTIVESIrritable bowel syndrome is a functional gastro intestinal disorder, with various symptomatology and difficult to treat using several medications. Spasmocanulase, which has an anti-spasmodic and anti-flatulence effect and contains several ingredients, was tried in patients with irritable bowel syndrome, who had been on other medications previously without improvement.METHODSAt the gastroenterology out-patient clinic, Armed Forces Hospital, Riyadh, Kingdom of Saudi Arabia, 21 patients who were diagnosed with irritable bowel syndrome for more than 2 years on treatment and did not benefit from these medications, received spasmocanulase one tablet 3 times a day and followed in the gastroenterology out-patient clinic, every 6 weeks for 6 months. Their previous medications were discontinued which, had been used for different durations and in different combinations included Mebeverine, Colpermin, Normacol, Importal, Librax. The main symptoms were different types of abdominal pain, bloating, flatulence, diarrhea, constipation or both.RESULTSThere was improvement or disappearance of the symptoms in more than 50% of the patients who were not improved on previous medication used for more than 2 years. The overall improvement in symptoms ranged between 43-75% in these patients, when followed up in the clinic at 6 weeks and 3 months. Spasmocanulase caused improvement in abdominal pain, flatulence and bloating compared to their previous medications. Only 43% of patients with diarrhea, showed improvement on spasmocanulase.CONCLUSIONAlthough the number of patients, we studied is small, this study has shown that spasmocanulase is beneficial in improving symptoms of irritable bowel syndrome.

01 Dec 1996·Journal of Emergency NursingQ3 · MEDICINE

A 74-year-old woman with weakness, shortness of breath, head and neck pain, cloudy urine, and EKG with wide QRS complex

Q3 · MEDICINE

Article

Author: Alton, S A

A 74-year-old patient was transported to our facility by ambulance from a local nursing home. She had weakness, shortness of breath, and head and neck pain with a sudden change in mental status. The patient had a medical history of hypertension, asthma, chronic obstructive pulmonary disease, and recent hospitalization for deep venous thromboses. Her medications included warfarin (Coumadin), albuterol, prednisone, levothyroxine (Synthroid), methyldopa (Aldomet), potassium (Micro K), hydrochlorothiaz ide (Maxzide), chlordiazepoxide (Librax), ranitidine (Zantac), iron supplement (Niferex), beclomethasone dipropionate (Beconase), and diphenoxylate (Lomotil). During transport the paramedics noticed a wide QRS complex with stable vital signs (Figure 1). On arrival in the emergency department the patient, an obese, white woman, was awake but had difficulty speaking and shortness of breath. The patient managed to report profound weakness with head and neck pain. Vital signs were as follows: blood pressure, 154/90 mm Hg; pulse, 78 beats/min; respirations, 36 breaths/min and shallow; and temperature, 97.5 ~ F rectally. Oxygen was administered at a rate of 6 L/min by mask; pulse oximetry revealed oxygen saturation of 98%. Breath sounds were clear bilaterally. Cardiac monitoring showed a regular heart rate, wide QRS complex, and tall T waves. Pulses were present and palpable. Heart tones were distant with normal first and second heart sounds, no third and fourth heart sounds, and no murmurs, gallops, or rubs. An IV infusion of lactated Ringer's solution was initiated at a keep-open

100 Deals associated with Chlordiazepoxide Hydrochloride/Clidinium Bromide

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External Link

KEGG	Wiki	ATC	Drug Bank
-	Chlordiazepoxide Hydrochloride/Clidinium Bromide	A03CA02	-

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Enterocolitis	United States	Bausch Health US LLC	01 Sep 1966
Irritable Bowel Syndrome	United States	Bausch Health US LLC	01 Sep 1966
Peptic Ulcer	United States	Bausch Health US LLC	01 Sep 1966