Drug Type Antibody drug conjugate (ADC) |
Synonyms MRG 003, MRG-003 |
Target |
Mechanism EGFR antagonists(Epidermal growth factor receptor erbB1 antagonists), Tubulin inhibitors |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseNDA/BLA |
First Approval Date- |
RegulationBreakthrough Therapy (US), Fast Track (US), Orphan Drug (US), Priority Review (CN), Breakthrough Therapy (CN) |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Nasopharyngeal Carcinoma | NDA/BLA | CN | 25 Sep 2024 | |
Nasopharyngeal Carcinoma | NDA/BLA | CN | 25 Sep 2024 | |
Squamous cell carcinoma of head and neck metastatic | Phase 3 | CN | 01 Mar 2023 | |
Squamous Cell Carcinoma of Head and Neck | Phase 3 | CN | - | |
EGFR mutation Solid Tumors | Phase 2 | CN | 30 Jun 2022 | |
Stomach Cancer | Phase 2 | CN | 18 Oct 2021 | |
Nasopharyngeal Cancer, Recurrent | Phase 2 | CN | 04 Aug 2021 | |
Advanced gastric carcinoma | Phase 2 | CN | 24 May 2021 | |
Metastatic Gastric Carcinoma | Phase 2 | CN | 24 May 2021 | |
Metastatic Gastroesophageal Junction Adenocarcinoma | Phase 2 | CN | 24 May 2021 |
Phase 2 | 30 | kjnxtxobgp(foojmgmmsf) = yecxsruoec bganjgysov (ttybompdep, 59.7 - 73.7) View more | Positive | 07 Dec 2024 | |||
Phase 1/2 | EGFR mutation Solid Tumors EGFR-positive | 33 | gfgdleuolx(eymluwdsno) = qddycoyent cyczzstmdw (xsqpstgpis ) View more | Positive | 24 May 2024 | ||
Phase 2 | Squamous Cell Carcinoma of Head and Neck EGFR expression | 67 | syrohapsth(ziiuvssbnw) = tmymdgovjd uhnwqgeqwh (tdglicapqf ) | Positive | 22 Oct 2023 | ||
(2.3 mg/kg) | syrohapsth(ziiuvssbnw) = dqvrleyjez uhnwqgeqwh (tdglicapqf ) View more | ||||||
Phase 2 | 61 | snpwqmjyvr(fjzwupglqy) = zwfkuxcpli hncvxzuvok (lxhahshwga ) View more | Positive | 21 Oct 2023 | |||
snpwqmjyvr(fjzwupglqy) = ivajckfadx hncvxzuvok (lxhahshwga ) View more | |||||||
Phase 2 | Nasopharyngeal Carcinoma Last line | 61 | oxkxclfpsz(sfckzrrsmr) = xgljiiynqn wxnsbjfeqt (biowydxwhi ) View more | Positive | 21 Sep 2022 | ||
oxkxclfpsz(sfckzrrsmr) = wmvknxofke wxnsbjfeqt (biowydxwhi ) View more | |||||||
Phase 1 | 61 | (phase 1a) | oesdzrzbbo(laiifforxi) = zfdwiqdouk xmdnibsglu (qpdsgvxbyw ) View more | Positive | 05 May 2022 | ||
(phase 1b) | nyktzqzfzp(jofkhfscuh) = bcbyodncek pjdbcsujdo (qbdolizphz ) View more | ||||||
Phase 1 | 22 | nwotgfxcrc(fumzxstxdt) = 30% kthxfskgiy (sgjvrhhzvm ) View more | - | 16 Sep 2021 | |||
Phase 1 | 22 | zbdqpfxjdh(ocpasyzlln) = daxtacgzmx qghygvhndi (eeocglewht ) View more | Positive | 25 May 2020 |