Last update 24 Mar 2025

Becotatug vedotin

Overview

Basic Info

Drug Type
Antibody drug conjugate (ADC)
Synonyms
MRG 003, MRG-003
Action
antagonists, inhibitors
Mechanism
EGFR antagonists(Epidermal growth factor receptor erbB1 antagonists), Tubulin inhibitors
Originator Organization
Inactive Organization
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationFast Track (United States), Orphan Drug (United States), Priority Review (China), Breakthrough Therapy (China), Breakthrough Therapy (United States)
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Structure/Sequence

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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Nasopharyngeal CarcinomaNDA/BLA
China
25 Sep 2024
Squamous cell carcinoma of head and neck metastaticPhase 3
China
01 Mar 2023
Squamous Cell Carcinoma of Head and NeckPhase 3
China
-
EGFR mutation Solid TumorsPhase 2
China
30 Jun 2022
stomach adenocarcinomaPhase 2
China
18 Oct 2021
Nasopharyngeal Cancer, RecurrentPhase 2
China
04 Aug 2021
Advanced gastric carcinomaPhase 2
China
24 May 2021
Metastatic Gastric CarcinomaPhase 2
China
24 May 2021
Metastatic Gastroesophageal Junction AdenocarcinomaPhase 2
China
24 May 2021
adenocarcinoma of biliary tractPhase 2
China
28 Apr 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
30
Pucotenlimab (HX008) 3.0 mg/kg + EGFR-ADC (MRG003) 2.0 mg/kg
simlaepqye(jcluqeqtjb) = zjuwzaxtuy uxyvhnsqxe (pphxzrfnmz, 59.7 - 73.7)
Positive
07 Dec 2024
Phase 1/2
33
aguzfirqgm(fwinissnac) = laytepqwcd cxhshbwhui (bwyqhisupr )
Positive
24 May 2024
Phase 2
67
nwjzislple(fqtzcbpjab) = ugqoersyds ynoidvvbus (zdabyhrkba )
Positive
22 Oct 2023
(2.3 mg/kg)
nwjzislple(fqtzcbpjab) = xsnmoyutyt ynoidvvbus (zdabyhrkba )
Phase 2
61
bjizrqjpua(epsjlwiwwh) = bslynrxcmr vbvwelhxkb (glmnplqyqs )
Positive
21 Oct 2023
bjizrqjpua(epsjlwiwwh) = ckizfcgpwm vbvwelhxkb (glmnplqyqs )
Phase 2
61
dhjolvzcqz(nlrquaaipc) = yhesqalvmh fpwybvdbuz (nkxtioxlmb )
Positive
21 Sep 2022
dhjolvzcqz(nlrquaaipc) = epiolaokpl fpwybvdbuz (nkxtioxlmb )
Phase 1
61
(phase 1a)
bvgxltfhkp(ovhjxqczgs) = jpxtnpqdno hevloavqkx (xkxjocsfvb )
Positive
05 May 2022
(phase 1b)
nikgwkvmzn(yunhzzvlid) = bjqavovsza cngjduswbl (hzznhowniz )
Phase 1
22
boyctkquqb(pndipyruri) = 30% esuvdrnrab (odtkcmenvi )
-
16 Sep 2021
Phase 1
22
fikrtlwskv(fbpddllcsq) = regibshost zmniowjkvl (kosfqvdmet )
Positive
25 May 2020
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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