ALK2 inhibitors(Activin receptor type-1 inhibitors), CSF-1R antagonists(Colony stimulating factor 1 receptor antagonists), FLT3 inhibitors(Tyrosine-protein kinase receptor FLT3 inhibitors)

Therapeutic Areas

Hemic and Lymphatic DiseasesOther DiseasesNeoplasms+ [1]

Active Indication

Primary MyelofibrosisThrombocytopeniaPost-essential thrombocythemia myelofibrosis+ [4]

Inactive Indication

Acute Myeloid LeukemiaAdult Acute Myeloblastic LeukemiaB-Cell Lymphoma+ [12]

Originator Organization

CTI BioPharma Corp.

Active Organization

Swedish Orphan Biovitrum AB

Swedish Orphan Biovitrum Ltd.Sobi, Inc.

+ [1]

Inactive Organization

S*BIO Pte Ltd.

Baxalta, Inc.

Drug Highest PhaseApproved

First Approval Date

US (28 Feb 2022),

Primary MyelofibrosisThrombocytopenia

RegulationPriority Review (US), Fast Track (US), Accelerated Approval (US), Orphan Drug (US)

Structure

Molecular FormulaC28H32N4O3

InChIKeyHWXVIOGONBBTBY-ONEGZZNKSA-N

CAS Registry937272-79-2

Clinical Trials associated with Pacritinib

NCT06675123 / Not yet recruitingPhase 1IIT

A Pilot Study of Pacritinib Combined With a BTK Inhibitor in Patients With Relapsed/Refractory Mantle Cell Lymphoma

This phase I trial tests the safety and side effects of pacritinib in combination with a Bruton's tyrosine kinase (BTK) inhibitor and how well it works in treating patients with mantle cell lymphoma that has come back after a period of improvement (relapsed) or that has not responded to previous treatment (refractory). Pacritinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. BTK inhibitors block a protein called BTK which is present on B-cell (a type of white blood cell) cancers such as mantle cell lymphoma at abnormal levels. This may help keep tumor cells from growing and spreading. Giving pacritinib in combination with a BTK inhibitor may be safe, tolerable and/or effective in treating patients with relapsed or refractory mantle cell lymphoma.

Start Date01 Nov 2025

Sponsor / Collaborator

City of Hope National Medical Center

[+1]

NCT06538181 / Not yet recruitingPhase 1IIT

A Phase 1 Study of Pacritinib in Vacuoles, E1 Ubiqutin-activating Enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) Syndrome

VEXAS (vacuoles, E1 ubiqutin-activating enzyme, X-linked, autoinflammatory, somatic syndrome) is a recently described disorder with severe hematologic and rheumatologic manifestations caused by somatic variants in the ubiquitin- activating enzyme gene, UBA1, that is acquired in hematopoietic progenitor cells. Patients are often debilitated by autoinflammatory symptoms and there is currently no standard of care available. There is a clinically unmet need for better therapies in VEXAS Syndrome. There have been no prospective clinical trials of JAK-I in VEXAS syndrome. The investigators hypothesize that pacritinib, as a JAK2/IRAK1 inhibitor with a manageable safety profile in myelofibrosis patients with thrombocytopenia, will improve the autoinflammatory and hematologic manifestations of VEXAS syndrome with a tolerable toxicity profile.
The investigators propose a single arm, pilot Phase 1 study evaluating the safety and tolerability of pacritinib in patients with VEXAS syndrome with an initial safety run-in phase of 6 patients treated with pacritinib 200mg twice daily (BID) on days 1-28 of a continuous 28 day cycle. If no more than 1 patient experiences a dose-limiting toxicity (DLT), the investigators will enroll an expansion cohort to gain additional toxicity and efficacy data, for a total enrollment of 15 patients. If more than 1 patient experiences a DLT during the safety run-in phase, the investigators will decrease the dose to 100 mg BID, and if no more than 1 of 6 patients experiences a DLT, the investigators will complete the expansion cohort as above for up to a total enrollment of 15 patients. If more than 1 patient experiences a DLT at 100 mg BID, the investigators will discontinue the study. Patients will be treated for up to 12 cycles.

Start Date31 Jan 2025

Sponsor / Collaborator

Washington University School of Medicine

[+1]

NCT06516887 / Not yet recruitingPhase 1/2IIT

A Phase Ib/II Open-Label, Dose-Escalation, Safety, Pharmacokinetic, Pharmacodynamic and Efficacy Study of Bemcentinib Plus Pacritinib In Patients With Advanced Lung Adenocarcinoma

This is a Phase Ib/II, open-label, single institution dose-escalation, safety, pharmacokinetics, pharmacodynamic and efficacy study.

Start Date01 Jan 2025

Sponsor / Collaborator

University of Texas Health Science Center At San Antonio

[+1]

100 Clinical Results associated with Pacritinib

100 Translational Medicine associated with Pacritinib

100 Patents (Medical) associated with Pacritinib

157

Literatures (Medical) associated with Pacritinib

01 Dec 2024·BIOORGANIC CHEMISTRY

Muti-target rationale design of novel substituted N-phenyl-2-((6-phenylpyridazin-3-yl)thio)acetamide candidates as telomerase/JAK1/STAT3/TLR4 inhibitors: In vitro and in vivo investigations

Article

Author: Alzahrani, Abdullah Yahya Abdullah ; Al-Karmalawy, Ahmed A. ; Al-Karmalawy, Ahmed A ; El-Dessouki, Ahmed M ; Moussa, Sana Ben ; El-Dessouki, Ahmed M. ; Tawfik, Haytham O ; Tawfik, Haytham O. ; Shaldam, Moataz A. ; Sharaky, Marwa ; Saleh, Mohamed M ; Mousa, Mai H.A. ; Saleh, Mohamed M. ; Mousa, Mai H A ; Shaldam, Moataz A

In this work, additional effort was applied to design new BIBR1532-based analogues with potential inhibitory activity against telomerase and acting as multitarget antitumor candidates to overcome the resistance problem. Therefore, novel substituted N-phenyl-2-((6-phenylpyridazin-3-yl)thio)acetamide candidates (4a-n) were synthesized. Applying the lead optimization strategy of the previously designed compound 8e; compound 4l showed an improved telomerase inhibition of 64.95 % and a superior growth inhibition of 79 % suggesting its potential use as a successful "multitarget-directed drug" for cancer therapy. Accordingly, compound 4l was further selected to evaluate its additional JAK1/STAT3/TLR4 inhibitory potentials. Compound 4l represented a very promising JAK1 inhibitory potential with a 0.46-fold change, compared to that of pacritinib reference standard (0.33-fold change). Besides, it showed a superior STAT3-inhibitory potential with a 0.22-fold change compared to sorafenib (0.33-fold change). Additionally, compound 4l downregulated TLR4 protein expression by 0.81-fold change compared to that of resatorvid (0.29-fold change). Also, molecular docking was performed to investigate the binding mode and affinity of the superior candidate 4l towards the four target receptors (telomerase, JAK1, STAT3, and TLR4). Furthermore, the therapeutic potential of compound 4l as an antitumor agent was additionally explored through in vivo studies involving female mice implanted with Solid Ehrlich Carcinoma (SEC). Remarkably, compound 4l led to prominent reductions in tumor size and mass. Concurrent enhancements in biochemical, hematologic, histopathologic, and immunohistochemical parameters further confirmed the suppression of angiogenesis and inflammation, elucidating additional mechanisms by which compound 4l exerts its anticancer effects.

01 Dec 2024·JOURNAL OF ONCOLOGY PHARMACY PRACTICE

Pacritinib and concurrent azole antifungal therapy is deliverable in patients with hematologic malignancies

Article

Author: Ali, Haris ; Tinajero, Jose ; Ngo, Dat ; Trang, Dina

Objective:

Pacritinib is a novel kinase inhibitor approved for the treatment of adults with intermediate or high-risk primary or secondary myelofibrosis. Strong and moderate CYP3A4 inhibitors, such as some azole antifungals, are contraindicated or recommended to be avoided in combination with pacritinib, respectively. We aim to report our experience in patients who received pacritinib with concurrent azole antifungal therapy.

Data Sources:

We queried for patients with hematologic malignancies in the electronic medical record who received concurrent pacritinib and azole antifungal therapy.

Data Summary:

There were five cases of concurrent pacritinib and azole antifungal therapy in which none of the patients experienced grade 3 or higher non-hematologic toxicities. Some patients required dose modifications and/or interruptions in pacritinib therapy.

Conclusion:

This is the first clinical experience describing concurrent pacritinib and azole antifungals. Our experience shows that in the setting where this interaction cannot be avoided, concurrent administration is feasible with close monitoring and possible empiric dose reductions in select patients.

01 Dec 2024·BIOMEDICINE & PHARMACOTHERAPY

Pacritinib prevents inflammation-driven myelofibrosis-like phenotype in a miR-146a murine model

Article

Author: Martínez, Constantino ; López-Poveda, María José ; Vidal-Garrido, Natalia ; Ferrer-Marín, Francisca ; Gonzalez-Conejero, Rocío ; Lozano, María Luisa ; Alcolea-Guardiola, Carlos ; Teruel-Montoya, Raúl ; Cuenca-Zamora, Ernesto José ; Guijarro-Carrillo, Pedro Jesús ; Morales, María Luz

Chronic proinflammatory signaling is a characteristic trait in myeloproliferative neoplasms (MPN), particularly myelofibrosis (MF). Aberrant inflammatory signaling, particularly from NF-κB pathway, exacerbates the progression of MPN. Previously, we identified a critical role of miR-146a, a negative regulator of the TLR/NF-κB axis, in MF development. MPN patients carrying the miR-146a rs2431697-TT genotype, associated with lower miR-146a expression levels, have a higher risk of progression to overt-MF from chronic-phase disease. Using miR-146a^-/- (KO) mice, a MF-like model lacking MPN driver mutations, we here investigate whether pacritinib, a dual JAK/NF-κB pathways inhibitor (via JAK2/IRAK1, respectively), prevents the age-associated myelofibrotic phenotype of these mice. Young miR-146a^-/- mice were treated either with or without pacritinib, for 3 or 6 months. Notably, pacritinib prevented the splenomegaly, reticulin fibrosis and osteosclerosis observed in untreated KO mice. Pacritinib also avoided the myeloproliferation, loss of splenic architecture, and extramedullary hematopoiesis observed in age-matched untreated KO mice. Pharmacological targeting of IRAK1/JAK2 attenuated the pro-inflammatory environment, preventing the increase of inflammatory cytokines, particularly CXCL1 and TNF-α, without inducing cytopenias but rather the opposite. Compared to age-matched untreated KO mice, treated mice showed higher platelet counts irrespective of treatment duration, and higher erythrocyte counts with the longer treatment. Additionally, pacritinib preventive treatment reduced COL1A1 production in an in vitro model mimicking JAK2-driven fibrosis. These findings highlight that dual inhibition of JAK2/IRAK1 with pacritinib, by delaying or attenuating the myelofibrotic progression, could be a potential modifier of the natural course of MPN.

News (Medical) associated with Pacritinib

03 Dec 2024

·www.prnewswire.com

Sobi's strength in haematology to be showcased at ASH 2024

STOCKHOLM, Dec. 3, 2024 /PRNewswire/ -- New data from Sobi® and partners will be presented at the 66th Annual Meeting of the American Society of Hematology (ASH) in San Diego, CA (USA) from the 7th - 10th of December 2024. During the meeting several analyses will be presented on haemophilia A, haemophagocytic lymphohistiocytosis (HLH), myelofibrosis, paroxysmal nocturnal haemoglobinuria (PNH), and immune thrombocytopenia (ITP). "Haemophilia A has a lasting impact on joint health and quality of life. At ASH 2024, three oral presentations will reveal important new data about long-term outcomes with ALTUVOCT® prophylaxis," said Lydia Abad-Franch, MD, MBA, Head of Research, Development, and Medical Affairs (RDMA), and Chief Medical Officer at Sobi. "We will also present new data spanning different severe and debilitating rare diseases, including an oral presentation on the real-world effectiveness of Doptelet® in treating people with ITP, demonstrating our broader commitment to advancing innovative treatments for people with rare haematological diseases. We look forward to sharing these findings in San Diego." Key data to be presented at ASH 2024 About ALTUVOCT® ALTUVOCT® (efanesoctocog alfa) [Antihemophilic Factor (Recombinant), Fc-VWF-XTEN Fusion Protein] (formerly BIVV001) is the first high-sustained FVIII replacement therapy with the potential to deliver near-normal factor activity levels for a significant part of the week, improving bleed protection in a once-weekly dose for people with haemophilia A. ALTUVOCT builds on the established Fc fusion technology by innovatively adding a region of von Willebrand factor and XTEN® polypeptides to extend its time in circulation. It is the only therapy that has been shown to break through the von Willebrand factor ceiling, which imposes a half-life limitation on current factor VIII therapies. The European Commission granted Orphan Drug designation in June 2019. It is approved and marketed as ALTUVOCT by Sobi in Europe. It is approved and marketed as ALTUVIIIO™ [Antihemophilic Factor (Recombinant), Fc-VWF-XTEN Fusion Protein-ehtl] by Sanofi in the United States, Japan, and Taiwan. About the Sanofi and Sobi collaboration Sobi and Sanofi collaborate on the development and commercialisation of Alprolix® and Elocta®/Eloctate®. The companies also collaborate on the development and commercialisation of ALTUVOCT® (efanesoctocog alfa), or ALTUVIIIO™ in the US. Sobi has final development and commercialisation rights in the Sobi territory (essentially Europe, North Africa, Russia, and most Middle Eastern markets). Sanofi has final development and commercialisation rights in North America and all other regions in the world excluding the Sobi territory. About Gamifant® Gamifant (emapalumab) is an anti-interferon gamma (IFNγ) monoclonal antibody that binds to and neutralises IFNγ. In the USA, Gamifant is indicated for the treatment of adult and paediatric (newborn and older) patients with primary haemophagocytic lymphohistiocytosis (HLH) with refractory, recurrent or progressive disease or intolerance with conventional HLH therapy. Primary HLH is a rare syndrome of hyperinflammation that usually occurs within the first year of life and can rapidly become fatal unless diagnosed and treated. The FDA approval is based on data from the phase 2/3 studies (NCT01818492 and NCT02069899). Gamifant is indicated for administration through intravenous infusion over one hour twice per week until haematopoietic stem cell transplantation (HSCT). About Vonjo® Vonjo (pacritinib), a JAK-1 sparing JAK2/IRAK1/ACVR1 inhibitor, is approved for the treatment of adults with intermediate- or high-risk primary or secondary (post-polycythemia vera or post-essential thrombocythemia) myelofibrosis with a platelet count below 50 × 109/L in the United States. This indication is approved under FDA accelerated approval based on spleen volume reduction. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial(s). Currently, a Phase 3 study (PACIFICA) is being conducted to assess pacritinib in patients with myelofibrosis and severe thrombocytopenia as a post-marketing requirement. About Aspaveli®/ Empaveli® Aspaveli/Empaveli (pegcetacoplan) is a targeted C3 and C3b inhibitor designed to regulate excessive activation of the complement cascade, part of the body's immune system, which can lead to the onset and progression of many serious diseases. Pegcetacoplan is approved for the treatment of paroxysmal nocturnal haemoglobinuria (PNH) as Aspaveli/Empaveli in the United States, European Union, and other countries globally. Currently, a Phase 3 trial (VALIANT) is being conduted to assess the efficacy and safety of pegcetacoplan in patients with C3G and primary IC-MPGN. Aspaveli/Empaveli is also under investigation for several other rare diseases across haematology and nephrology. About the Sobi and Apellis collaboration Sobi and Apellis have global co-development rights for systemic pegcetacoplan. Sobi has exclusive ex-U.S. commercialisation rights for systemic pegcetacoplan, and Apellis has exclusive U.S. commercialisation rights for systemic pegcetacoplan and worldwide commercial rights for ophthalmological pegcetacoplan, including for geographic atrophy. About Doptelet® Doptelet (avatrombopag) is an orally administered thrombopoietin receptor agonist (TPO-RA) that mimics the biologic effects of TPO in stimulating the development and maturation of megakaryocytes, resulting in increased platelet count. It is approved in over 30 countries worldwide, including the EU and the US, for the treatment of severe thrombocytopenia in adult patients with chronic liver disease who are scheduled to undergo an invasive procedure, and for the treatment of thrombocytopenia in adult patients with primary chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment. Chronic ITP is a rare autoimmune bleeding disorder characterised by low number of platelets. The incidence of primary ITP in adults is 3.3/100,000 adults per year with a prevalence of 9.5 per 100,000 adults. About Sobi® Sobi® is a specialised international biopharmaceutical company transforming the lives of people with rare and debilitating diseases. Providing reliable access to innovative medicines in the areas of haematology, immunology, and specialty care, Sobi has approximately 1,800 employees across Europe, North America, the Middle East, Asia, and Australia. In 2023, revenue amounted to SEK 22.1 billion. Sobi's share (STO:SOBI) is listed on Nasdaq Stockholm. More about Sobi at sobi.com and LinkedIn. Contacts For details on how to contact the Sobi Investor Relations Team, please click here. For Sobi Media contacts, click here. This information was brought to you by Cision The following files are available for download: WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Drug ApprovalPhase 3ASHOrphan DrugLicense out/in

24 Oct 2024

·www.prnewswire.com

Sobi Q3 2024 report: Strong growth and significant pipeline momentum

STOCKHOLM, Oct. 24, 2024 /PRNewswire/ -- Swedish Orphan Biovitrum AB (publ) (Sobi®) today announced its report for the third quarter 2024 Third Quarter 2024 Total revenue increased 33 per cent, 39 per cent at constant exchange rates, (CER)1, to SEK 6,894 M (5,168) Haematology revenue increased 18 per cent at CER to SEK 4,000 M (3,484), mainly driven by strong sales of Doptelet® of SEK 1,039 M (650), sales of Aspaveli®/Empaveli® of SEK 270 M (169) and launch sales of Altuvoct® of SEK 129 M (—) Immunology revenue increased 96 per cent at CER to SEK 2,583 M (1,400), driven by strong Beyfortus® royalty of SEK 1,478 M (263) and sales of Kineret® of SEK 699 M (600) Revenue from medicines in the strategic portfolio* grew by 113 per cent at CER to SEK 3,830 M (1,924) The adjusted EBITA margin1,2 was 43 per cent (30), excluding items affecting comparability (IAC)2. EBITA was SEK 2,923 M (1,443), corresponding to a margin of 42 per cent (28). EBIT was SEK 2,038 M (547) Earnings per share (EPS) before dilution was SEK 4.27 (0.30). Adjusted EPS before dilution1 was SEK 4.36 (0.54). Cash flow from operating activities was SEK 1,201 M (1,058) In August, Sobi and Apellis Pharmaceuticals announced positive topline results from the Phase 3 VALIANT study of pegcetacoplan in C3G and primary IC-MPGN Outlook 2024 - Updated Revenue is anticipated to grow by a mid-teens percentage at CER (previously low double-digit) The adjusted EBITA margin is anticipated to be in the mid-30s percentage of revenue (unchanged) Click here for the Financial Summary. Alternative Performance Measures (APMs). Items affecting comparability (IAC). * The strategic portfolio includes Sobi's medicines Altuvoct, Aspaveli/Empaveli, Doptelet, Gamifant®, Vonjo® and Zynlonta®, and royalty on Sanofi's sales of Altuviiio® and Beyfortus. Investors, analysts, and the media are invited to a conference call on the same day at 14:00 CEST, 13:00 BST, and 08:00 EDT. The call will include a presentation of the results and a Q&A session. The presentation can be followed live here or afterwards on sobi.com. The slides will be made available on sobi.com before the conference call. To participate in the conference call, please use the following dial-in details: Sweden: +46 8 5051 0031 United Kingdom: +44 207 107 06 13 United States: +1 631 570 56 13 For other countries, please find the details here. Sobi Sobi® is a specialised international biopharmaceutical company transforming the lives of people with rare and debilitating diseases. Providing reliable access to innovative medicines in the areas of haematology, immunology and specialty care, Sobi has approximately 1,800 employees across Europe, North America, the Middle East, Asia and Australia. In 2023, revenue amounted to SEK 22.1 billion. Sobi's share (STO:SOBI) is listed on Nasdaq Stockholm. More about Sobi at sobi.com and LinkedIn. For details on how to contact the Sobi Investor Relations Team, please click here. For Sobi Media contacts, click here. This information is information that Sobi is obliged to make public pursuant to the EU Market Abuse Regulation. The information was submitted for publication, through the agency of the contact person set out below, at 08:00 CEST on 24 October 2024. Gerard Tobin Head of Investor Relations This information was brought to you by Cision The following files are available for download: SOURCE Swedish Orphan Biovitrum AB WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Financial StatementClinical ResultPhase 3Biosimilar

16 Jul 2024

·www.prnewswire.com

Sobi Q2 2024 report: Strong delivery driven by robust portfolio performance

Swedish Orphan Biovitrum AB (publ) (Sobi®) today announced its report for the second quarter 2024 STOCKHOLM, July 16, 2024 /PRNewswire/ -- Second Quarter 2024 Total revenue increased 12 per cent, 11 per cent at constant exchange rates, (CER), to SEK 5,442 M (4,872) Haematology revenue increased 13 per cent at CER to SEK 3,866 M (3,430), reflecting growth in all medicines, mainly driven by strong sales of Doptelet® excluding sales to China of SEK 928 M (567), sales of Vonjo® of SEK 347 M (36) and sales of Aspaveli®/Empaveli® of SEK 251 M (144) Immunology revenue increased 7 per cent at CER to SEK 1,277 M (1,179), driven by strong sales of Kineret® of SEK 745 M (661) and Gamifant® of SEK 522 M (491) Revenue from medicines in the strategic portfolio grew by 74 per cent at CER to SEK 2,219 M (1,258) The adjusted EBITA margin was 28 per cent (26), excluding items affecting comparability (IAC). EBITA was SEK 1,486 M (1,009), corresponding to a margin of 27 per cent (21). EBIT was SEK 612 M (413) Earnings per share (EPS) before dilution was SEK 0.66 (0.71). Adjusted EPS before dilution was SEK 0.72 (1.41). Cash flow from operating activities was SEK 2,329 M (357) Altuvoct® (efanesoctocog alfa) was EU approved for once-weekly treatment of haemophilia A Aspaveli was EU approved for use among treatment naïve adult patients with PNH Biologics license application to FDA initiated for SEL-212 for the potential treatment of chronic refractory gout Outlook 2024 - updated Revenue is anticipated to grow by low double-digit percentage at CER (previously high single-digit) The adjusted EBITA margin is anticipated to be in the mid-30s percentage of revenue (unchanged) The strategic portfolio includes Sobi's medicines Aspaveli/Empaveli, Doptelet excluding China, Gamifant, Vonjo and Zynlonta®, and royalty on Sanofi's sales on Altuviiio® and Beyfortus®. Investors, analysts and media are invited to participate in a conference call, which will include a presentation of the results and a Q&A session on the same day at 14:00 CEST. The presentation can be followed live here or afterwards on sobi.com. The slides will be made available on sobi.com before the conference call. To participate in the conference call, please use the following dial-in details: Sweden: +46 8 5051 0031 United Kingdom: +44 207 107 06 13 United States: +1 631 570 56 13 For other countries, please find the details here. Sobi Sobi® is a specialised international biopharmaceutical company transforming the lives of people with rare and debilitating diseases. Providing reliable access to innovative medicines in the areas of haematology, immunology and specialty care, Sobi has approximately 1,800 employees across Europe, North America, the Middle East, Asia and Australia. In 2023, revenue amounted to SEK 22.1 billion. Sobi's share (STO:SOBI) is listed on Nasdaq Stockholm. More about Sobi at sobi.com and LinkedIn. Contacts For details on how to contact the Sobi Investor Relations Team, please click here. For Sobi Media contacts, click here. This information is information that Sobi is obliged to make public pursuant to the EU Market Abuse Regulation and the Swedish Securities Markets Act. The information was submitted for publication, through the agency of the contact person set out below, on 16 July 2024 at 08:00 CEST. Gerard Tobin Head of Investor Relations This information was brought to you by Cision The following files are available for download:

Drug ApprovalBiosimilarFinancial Statement

100 Deals associated with Pacritinib

External Link

KEGG	Wiki	ATC	Drug Bank
D11768	Pacritinib	-	DB11697

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Primary Myelofibrosis	US	Swedish Orphan Biovitrum Ltd.	28 Feb 2022
Thrombocytopenia	US	Swedish Orphan Biovitrum Ltd.	28 Feb 2022

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Post-essential thrombocythemia myelofibrosis	Phase 3	BE	CTI BioPharma Corp.	01 Jan 2013
Post-essential thrombocythemia myelofibrosis	Phase 3	NL	CTI BioPharma Corp.	01 Jan 2013
Post-essential thrombocythemia myelofibrosis	Phase 3	NZ	CTI BioPharma Corp.	01 Jan 2013
Post-polycythemia vera myelofibrosis	Phase 3	BE	CTI BioPharma Corp.	01 Jan 2013
Post-polycythemia vera myelofibrosis	Phase 3	NL	CTI BioPharma Corp.	01 Jan 2013
Post-polycythemia vera myelofibrosis	Phase 3	NZ	CTI BioPharma Corp.	01 Jan 2013
COVID-19	Phase 2	US	CTI BioPharma Corp.	22 May 2020
Graft vs Host Disease	Phase 2	US	CTI BioPharma Corp.	08 Jun 2017
Refractory Colorectal Carcinoma	Phase 2	US	CTI BioPharma Corp.	22 Sep 2015
Leukemia	Phase 2	US	S*BIO Pte Ltd.	01 Dec 2011

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01773187 \| NCT02055781 \| NCT04884191 (PERSIST-1, PERSIST-2, PAC203, ASH2024)	Phase 2/3	serum albumin \| cholesterol	484	Pacritinib 400 mg QD	fdqftfvsne(pqnnhxsmcb) = tviiadrvkx hgkyinregu (kkcbddvaeh, -1.3 to +3.14)	Positive	08 Dec 2024
ASH2024	Not Applicable	Myelofibrosis	-	Pacritinib	daecuzulrk(udzpcpwpnc) = lihhdlwpdx anzxooysbr (fxqpyhcpoj, 63.2 - 99.0) View more	-	08 Dec 2024
SOHO2024	Not Applicable	Myelofibrosis	-	Pacritinib	lmbnopukjz(ffpoivacoc) = fwtmjnnxts mwuiopnffa (vyutgwnefg, 7.9 - 10.3) View more	-	04 Sep 2024
NCT02055781 (PERSIST-2, SOHO2024)	Phase 3	Anemia \| Thrombocytopenia \| Myelofibrosis	-	Pacritinib 200 mg twice daily	wfbcsecfuh(pvuunctdll) = ejdxzwcvds yeqryubyqz (nlvisfhgzq ) View more	Positive	04 Sep 2024
				Best Available Therapy (BAT)	wfbcsecfuh(pvuunctdll) = vxdprgpyux yeqryubyqz (nlvisfhgzq ) View more
SOHO2024	Not Applicable	Myelofibrosis	-	Pacritinib 200 mg twice daily	ypetegcbzw(ryzlkmeuvv) = oovmbnieih mmwakcjflx (gkrylkusoj ) View more	-	04 Sep 2024
				Best Available Therapy (BAT)	ypetegcbzw(ryzlkmeuvv) = yyrrfzfaly mmwakcjflx (gkrylkusoj ) View more
NCT02807207 (MPN-302, SOHO2024)	Phase 1	-	42	Moxifloxacin 400 mg	rsbsqqvlvw(qroamymnjd) = 29.3% bytnswvzut (mtypxtllan ) View more	Positive	04 Sep 2024
NCT04404361 (PRE-VENT, CTgov)	Phase 2	COVID-19 \| Neoplasms	200	Pacritinib (Pacritinib and SOC)	bhftzboftm(rybmmjlyts) = gexzcwtjic gfpiuxmics (kqrzijsnzi, nftpkwtlrd - yrqbcqnmtd) View more	-	05 Jun 2024
				Placebo (Placebo and SOC)	bhftzboftm(rybmmjlyts) = xllunevcoh gfpiuxmics (kqrzijsnzi, ehullscrdf - pnqpfidsnb) View more
NCT02055781 (PERSIST-2, ASCO2024) Manual	Phase 3	Myelofibrosis	93	Pacritinib 200 mg twice daily	(boxpjnqmad) = hyxtbppmrt aueotgebbq (mbzbzirleb ) View more	Positive	24 May 2024
				Best Available Therapy (BAT)	(boxpjnqmad) = aipvigqqth aueotgebbq (mbzbzirleb ) View more
ASCO2024 Manual	Not Applicable	Myelofibrosis Third line	142	Pacritinib	tuetmfayvh(zguetrhpmo) = diaancxtid gqxazwapnc (nuvzgsbtuo, 56.8 - 79.0) View more	Positive	24 May 2024
NCT02055781 (PERSIST-2, ASCO2024) Manual	Phase 3	Thrombocytopenia \| Myelofibrosis	92	Pacritinib 200 mg twice daily	nenbcbqnuo(xfshkwsdoz) = xsefmotxfz juyysiesun (fiworkmvts ) View more	Positive	24 May 2024
				Best Available Therapy (including Ruxolitinib)	nenbcbqnuo(xfshkwsdoz) = imfkhuddfr juyysiesun (fiworkmvts ) View more

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