Trauma is the leading cause of death and disability in children in the United States. The objective of this study is to evaluate the benefits and harms of tranexamic acid (TXA; a drug that stops bleeding) in severely injured children with hemorrhagic brain and/or torso injuries. Using thromboelastography, we will measure baseline fibrinolysis to assess for treatment effects of TXA at different levels of fibrinolysis.

Start Date01 Oct 2025

Sponsor / Collaborator

University of California, Davis

NCT06718751

/ Not yet recruitingPhase 2IIT

Tranexamic Acid Therapy For The Treatment of Subdural Hematomas

This Phase II randomized, placebo-controlled, double-blinded trial is the first step in our endeavor to improve the clinical outcomes of patients with chronic subdural hematomas (cSDH). Patients who are deemed to not need surgery for their cSDH will be randomly assigned to either the treatment group or the placebo group. Both groups will take a 650mg tablet once daily for 21 weeks and follow the standard of care monitoring for cSDH which is neurological testing and imaging at 6 weeks, 12 weeks, and 21 weeks. With this study, we hope to establish the safety and efficacy of using TXA PO to resolve cSDH without the need for surgical intervention.

Start Date01 Oct 2025

Sponsor / Collaborator

Baylor College of Medicine

100 Clinical Results associated with Tranexamic Acid

100 Translational Medicine associated with Tranexamic Acid

100 Patents (Medical) associated with Tranexamic Acid

9,542

Literatures (Medical) associated with Tranexamic Acid

31 Dec 2025·Journal of Maternal-Fetal & Neonatal Medicine

Accordance between weight-based and calculated blood loss for obstetric hemorrhage: a pre-study to a randomized controlled trial

Article

Author: Skogvard, Linnea ; Endler, Margit ; Strindfors, Gita

OBJECTIVE:

Postpartum hemorrhage (PPH) is the leading cause of maternal death. Identifying excessive bleeding is crucial, but there is no gold standard for its measurement. We aimed to assess accordance between two formulas for calculated blood loss (CBL) and weight-based blood loss (WBBL) to determine if CBL has a place in either the clinical or research obstetric context.

METHOD:

This was a pre-posttest study nested in a pilot study. Women ≥ 18years and ≥ 36 gestational weeks with uncomplicated pregnancies and planned vaginal birth were included at a tertiary hospital in Stockholm, Sweden from December 2022 to February 2023. Hematocrit (Erythrocyte Volume Fraction, EVF) and hemoglobin (Hb) were taken at admission and 24 h postpartum. Blood loss was calculated in three ways: weighing blood collected in drapes and blood-soaked material; Gross's formula based on pre-postpartum EVF; and pre-postpartum Hb difference, assuming a 10 mg/L difference equivalent to 500 ml. We compared median blood loss between these methods using Related-samples Wilcoxon Signed-Rank Test, correlations using Spearman's Rho, and prediction of PPH (≥500 ml) using McNemar's test.

RESULTS:

Out of 51 women included in the pilot, 37 and 36 had data for each CBL method respectively. Median blood loss was 350 ml for WBBL, 649 ml for Gross's formula (p = 0.008) and 750 ml for pre-postpartum Hb difference (p < 0.001). For the diagnosis PPH, WBBL and Gross's formula were concordant in 61% of cases (p = 0.002), compared to 43% for WBBL and pre-postpartum Hb difference (p = 0.001). There was a moderate positive correlation between WBBL and both CBL methods (p = 0.001). Excluding women who received intravenous fluids did not improve agreement between WBBL and CBL methods.

DISCUSSION:

Both CBL methods significantly differ from, and overestimate bleeding compared to WBBL. There is a correlation between WBBL and CBL, but the estimates differ to the extent that CBL methods do not seem relevant for clinical obstetric practice or research.

01 Dec 2025·LUNG

Effectiveness of Inhalational Tranexamic Acid in Patients with Nonmassive Hemoptysis–A Systematic Review and Meta-Analysis

Review

Author: Krishnamoorthy, Yuvaraj ; Salih, Anas ; Elanjeran, Rajkumar ; Rajendran, Gunaseelan ; Dinesh, Vasudha ; Ramkumar, Anitha ; Kannan, Rahini ; Mahalingam, Sasikumar ; Thirthar Palanivelu, Elamurugan ; Ponnaeasu, Sathya Prakasham

BACKGROUND:

Hemoptysis, the expectoration of blood from the lower respiratory tract, varies in severity and necessitates effective management to mitigate morbidity. Traditional treatments include bronchial artery embolization and pharmacological approaches. Tranexamic acid (TXA), an antifibrinolytic agent known for its efficacy in reducing bleeding during surgery and trauma, is being explored for its efficacy in treating Hemoptysis via both intravenous and inhalational routes. Inhalational administration has garnered interest because of its targeted action and minimal systemic effects. This study aimed to assess the effectiveness of inhalational TXA in nonmassive hemoptysis.

METHODS:

A systematic literature search encompassing PubMed Central, EMBASE, SCOPUS, and ProQuest was conducted. Randomized controlled trials (RCTs) and observational studies assessing the effectiveness of inhalational tranexamic acid for nonmassive hemoptysis were included. Comparative intervention effect estimates from meta-analyses are reported as pooled odds ratios and pooled mean differences with 95% confidence interval (CI).

FINDINGS:

Analysis of three RCTs and two observational studies, comprising 351 patients (192 cases and 159 controls), revealed varying risk levels of bias across the studies. Nebulized tranexamic acid was 3.85 times more likely to achieve hemoptysis cessation than alternative treatments across all RCTs. Moreover, patients receiving nebulized tranexamic acid required fewer (43%) pulmonary interventional procedures than those receiving other treatments. Despite showing a trend towards reducing posttherapy bleeding (20 ml less), conclusive results were hindered by wide CI, necessitating further investigation.

INTERPRETATION:

Nebulized tranexamic acid may be a potential therapeutic option for nonmassive hemoptysis. While our analysis suggests its potential benefits in halting bleeding and reducing the need for invasive procedures, the quality of the available evidence is limited due to the risk of bias and study limitations. This underscores the necessity for additional randomized controlled trials with larger sample sizes and rigorous study designs to strengthen evidence and optimize clinical utility.

PROSPERO REGISTRATION:

The registration for this systematic review and meta-analysis was completed through Prospero on January 30, 2024, with the registration number CRD42024501624.

01 Dec 2025·European Journal of Trauma and Emergency Surgery

Tranexamic acid: single topical application for femoral neck fractures treated with arthroplasty results in lowest blood loss

Article

Author: Lisitano, Leonhard ; Fenwick, Annabel ; Förch, Stefan ; Koenemann, Nora ; Anna, Kurnoth ; Röttinger, Timon ; Mayr, Edgar

Abstract:

Purpose:

Tranexamic acid is widely accepted for hip fractures but there is no agreement about dose or application method and the use is still off label for hip fractures. The aim of our study was to find the best application method of tranexamic acid in patients with femoral neck fractures comparing total blood loss, hemoglobin and transfusion rate.

Methods:

A retrospective single centre cohort study (level I trauma centre) with 2008 patients treated operatively for a proximal femur fracture between January 2016 and January 2022 was performed. 1 g of tranexamic acid was applied in 314 cases (systemic, topic or combined application) if patients consented. Patient data, surgical procedure, complications, and mortality were assessed. Haemoglobin levels, blood loss and transfusion rates were compared amongst application methods.

Results:

For 884 femoral neck fractures treated with arthroplasty blood loss was significantly reduced by tranexamic acid which 314 had received in total (1151.0 ml vs 738.28 ml; p < 0.001). 151 patients received 1 g of tranexamic acid systemically which reduced blood loss from 1151 to 943.25 ml. Combined application of 1 g i.v. and 1 g topically reduced blood loss even further to 869.79 ml and topical application achieved the lowest total blood loss at 391.59 ml (average reduction of 759.41 ml compared to without tranexamic acid), p < 0.001. Transfusion rate and amount of RBC units transfused were the lowest for topical use and showed the highest hemoglobin levels postoperatively. Complication rates did not differ for adverse vascular events.

Conclusion:

Tranexamic acid effectively reduces blood loss and transfusion rates and shows higher hemoglobin levels postoperatively, without increasing the risk of thromboembolic events after proximal femoral fractures. Single topic application of 1 g for arthroplasty treatment of femoral neck fractures has better results for blood loss reduction than single i.v. or combined application.

107

News (Medical) associated with Tranexamic Acid

10 Jul 2025

·www.einpresswire.com

Antifibrinolytic Drugs Market to Hit $19.3 Billion by 2026 Amid Rising Demand for Hemorrhage Control

North America accounted for majority of the market share in 2018 and is anticipated to continue this trend during the forecast period. PORTLAND, OR, UNITED STATES, July 10, 2025 / EINPresswire.com / -- The Antifibrinolytic Drugs Market size was estimated at $13.59 billion in 2018 and is expected to hit at $19.33 billion by 2026, registering a CAGR of 4.5% from 2019 to 2026. The report provides a detailed analysis of the market size & estimations, top investment pockets, top winning strategies, drivers & opportunities, competitive scenario, and wavering market trends. ► Don't Miss Out “Download Your Exclusive Sample PDF Report” Now: https://www.alliedmarketresearch.com/request-sample/6279 Antifibrinolytics are one of the most commonly used drugs to prevent fibrinolysis by blocking the activation of plasminogen proenzyme and plasmin. This intervention is critical to avoid clotting in areas that are prone to fibrinolysis such as the oral cavity, nasal cavity and female genitalia. Recommended antifibrinolytic drugs include Epsilon aminocaproic acid, tranexamic acid, Amicar, aminocaproic acid, aprotinin, and Cyklokapron. Also, these drugs find their application in surgery such as heart surgery, neurosurgeries and dental surgery. In addition, women use antifibrinolytic drugs to control heavy menstruation. Major market players covered in the report, such as - Akorn Inc., Aurobindo Pharma Limited, Bayer AG, Ferring Holding SA, Mylan N.V., Novartis International AG (Sandoz), Pfizer Inc., Sanofi S.A., Takeda Pharmaceutical Company Limited, Vitruvias Therapeutics Inc. Key Benefits for Stakeholders - • The report provides quantitative analysis of market segments, current trends, strategies and potential of antifibrinolytic drugs market research to identify potential antifibrinolytic drugs market opportunities in genetics. • In-depth analysis of this sector helps identify current market opportunities. • Market analysis and information related to key drivers, restraints and opportunities are provided. • Porter's Five Forces Analysis identifies the capabilities of buyers and suppliers to enable stakeholders to make profitable business decisions and strengthen the network of buyers. • The largest countries in each region are listed according to their contribution to the global market. • Focusing on market players makes benchmarking easier and provides a clear understanding of the current market situation. • The report includes regional and global antifibrinolytic drugs market analysis, key players, market segments, application areas and Market growth strategies. ★ Procure Complete Report [ 220 Pages PDF with Insights, Charts, Tables, and Figures ] @ https://www.alliedmarketresearch.com/request-for-customization/6279 Antifibrinolytic drugs or agents are used in specific situations or in combination with clotting factor replacement to treat hemophilia. These prevent the breakdown of blood clots by counteracting chemicals in the mucous membrane. Antifibrinolytics are increasingly being used in operations associated with high risk of bleeding. These drugs are useful in the management of optimal coagulation. TABLE OF CONTENT - CHAPTER 1 - INTRODUCTION: 1.1. Report description 1.2. Key market segments 1.3. List of key players profiled in the report 1.4. Research methodology 1.4.1. Secondary research 1.4.2. Primary research 1.4.3. Analyst tools & models CHAPTER 2 - EXECUTIVE SUMMARY: 2.1. Key findings of the study 2.2. CXO Perspective CHAPTER 3 - MARKET OVERVIEW: 3.1. Market Definition and Scope 3.2. Key Findings 3.2.1. Top investment pockets 3.2.2. Top winning strategies 3.3. Market Share Analysis/Top Player Positioning 3.4. Porter’s Five Forces Analysis 3.5. Market Dynamics 3.5.1. Drivers 3.5.2. Restraints 3.5.3. Opportunities… 3.6. COVID-19 Impact Analysis on the market North America accounted for the largest share of the antifibrinolytic drugs market in 2018 and is expected to continue this trend during the forecast period. This is due to the increasing number of women using these drugs to control heavy periods. Additionally, a significant increase in surgeries in this region is driving the market growth. However, the Asia-Pacific region is expected to experience rapid growth due to the rise in road accidents and the increase in the use of these drugs by women to control menstrual cycle. 👉 For Purchase Inquiry of Report: https://www.alliedmarketresearch.com/purchase-enquiry/6279 The antifibrinolytic drugs market is expected to witness a significant growth in the coming years. This market has gained interest of the healthcare and medical sectors owing to increased prevalence of hypertension throughout the globe. Furthermore, the global antifibrinolytic drugs market is segmented on the basis of product type, end user, and region. leading market players have been introducing various strategies to help enterprises move their on-premise models to on-demand models. Frequently Asked Questions? Q1. What is the total market value of antifibrinolytic drugs market report? Q2. Which are the top companies holding the market share in antifibrinolytic drugs market? Q3. Which are the largest regions for this Market? Q4. What is the leading technology of antifibrinolytic drugs market? Q5. What are the major drivers for this specific Market? Q6. What are the upcoming key trends in the antifibrinolytic drugs market report? About Us - Allied Market Research (AMR) is a full-service market research and business-consulting wing of Allied Analytics LLP based in Portland, Oregon. Allied Market Research provides global enterprises as well as medium and small businesses with unmatched quality of "Market Research Reports" and "Business Intelligence Solutions." AMR has a targeted view to provide business insights and consulting to assist its clients to make strategic business decisions and achieve sustainable growth in their respective market domain. Pawan Kumar, the CEO of Allied Market Research is leading the organization toward providing high-quality data and insights. We are in professional corporate relations with various research data tables and confirms utmost accuracy in our market forecasting. Each and every us companies and this helps us in digging out market data that helps us generate accurate y data presented in the reports published by us is extracted through primary interviews with top officials from leading companies of domain concerned. Our secondary data procurement methodology includes deep online and offline research and discussion with knowledgeable professionals and analysts in the industry. David Correa Allied Market Research + +1 800-792-5285 email us here Visit us on social media: LinkedIn Facebook YouTube X Legal Disclaimer: EIN Presswire provides this news content "as is" without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.

19 Mar 2025

·www.pharmaindustrial-india.com

Nexus Pharmaceuticals Launches Tranexamic Acid

Nexus Pharmaceuticals, a US-based healthcare company, has introduced Tranexamic Acid. This milestone is another step for Nexus in its mission to provide life-saving medication to those who need it most. “We are very excited to be adding Tranexamic Acid to our product portfolio. Antifibrinolytic Agents, such as Tranexamic Acid, are crucial to have available in operating rooms and we are proud to contribute to the supply,” said Vince LoPiccolo, Vice President of Sales at Nexus. Tranexamic Acid is now available in cartons of 10 bags. Nexus Pharmaceuticals, LLC., a US-based healthcare company, specializes in innovative processes to make difficult-to-manufacture specialty and generic drugs that are easier to use, less labor intensive, and more streamlined in practice. Nexus ensures that its high-quality drug products fulfill a critical unmet medical need and deliver dependable life-saving treatment options when and where they’re needed most.

13 Mar 2025

·www.pharmaceutical-technology.com

Gedeon Richter’s once-daily endometriosis pill approved for NHS use

Endometriosis can cause severe pain, heavy periods, fatigue, and fertility issues. Credit: LaylaBird via Getty Images. The UK’s National Institute for Health and Care (NICE) has approved Gedeon Richter’s Ryeqo (relugolix–estradiol–norethisterone), a once-daily oral treatment for endometriosis, for use on the National Health Service (NHS). The drug works by blocking gonadotrophin releasing hormone (GnRH) that contributes to endometriosis while simultaneously providing necessary hormone replacement. Unlike traditional GnRH agonists – such as Takeda’s Prostap (leuprorelin) and AstraZeneca’s Zoladex (goserelin) – which are limited to six months of use, Ryeqo can be taken until menopause. NICE estimates that around 1,000 women per year could benefit from the treatment, which has a list price of £72 per 28-day pack. Helen Knight, director of medicines evaluation at NICE, highlighted the benefits of a pill-based treatment: “Instead of travelling to clinics for injections, there is now a daily tablet that can be taken at home. The treatment can also be stopped and started more easily, which is particularly important for those planning to have children and for managing side effects.” Endometriosis, a condition where tissue similar to the womb lining grows outside the uterus, causes severe pain, heavy periods, fatigue and fertility issues. Current treatment options include pain relief, hormonal therapy, and surgery. Ryeqo is now an option for those who have previously undergone medical or surgical treatments but found alternatives like tranexamic acid, hormonal contraceptives, and intrauterine delivery systems ineffective or unsuitable. NICE’s final draft guidance emphasised the need for non-invasive, long-term treatment options for endometriosis symptoms, as there is no cure. Charities, including Endometriosis UK, welcomed the news, but noted that Ryeqo induces a state of “medical menopause” alongside hormone replacement therapy (HRT), meaning it may only be suitable for “a small proportion of the 1.5 million with the disease”. NICE reversed its previous negative stance on the drug after Gedeon Richter provided additional evidence on the drug’s effectiveness and cost-effectiveness. Ryeqo improved endometriosis-associated pain and was well tolerated compared to placebo in the Phase III SPIRIT 1 (NCT03204318) and SPIRIT 2 (NCT03204331) clinical studies, which enrolled over 1,200 women. Beyond the approval of new treatments, Endometriosis UK has called for greater investment in research to find the root cause of the disease, improve management strategies, and to develop a cure. At the Royal Society of Medicine’s Innovation in Women’s Health and Femtech meeting on 3 March 2025, McKinsey partner Anouk Petersen pointed out that despite affecting a similar proportion of the population as diabetes (about 10%), endometriosis receives eight to ten times less funding. A report from McKinsey & Company and the World Economic Forum underscored the economic impact of conditions like endometriosis, finding that while women live longer than men, they spend 25% more of their lives in debilitating health conditions. This has direct productivity consequences, with 60% of the gender health gap occurring during prime working years, contributing to 80% of the economic burden on gross domestic product (GDP). According to GlobalData’s Pharma Intelligence Center, Ryeqo is forecast to generate up to $775m in sales in 2030. GlobalData is the parent company of Pharmaceutical Technology.

Clinical ResultDrug ApprovalPhase 3

100 Deals associated with Tranexamic Acid

External Link

KEGG	Wiki	ATC	Drug Bank
D01136	Tranexamic Acid	B02AA02	DB00302

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Menorrhagia	United States	Amring Pharmaceuticals SA	13 Nov 2009
Hemophilia	United States	Pfizer Inc.	30 Dec 1986
Hemophilia	United States	Pharmacia & Upjohn, Inc.	30 Dec 1986
Erythema	Japan	Nipro Pharma Corp.	16 Jan 1969
Pruritus	Japan	Nipro Pharma Corp.	16 Jan 1969
Tumescence	Japan	Nipro Pharma Corp.	16 Jan 1969
Drug Eruptions	Japan	Daiichi Sankyo Co., Ltd.	31 Aug 1965
Hemorrhage	Japan	Daiichi Sankyo Co., Ltd.	31 Aug 1965
Pharyngolaryngitis	Japan	Daiichi Sankyo Co., Ltd.	31 Aug 1965
Stomatitis	Japan	Daiichi Sankyo Co., Ltd.	31 Aug 1965
Tonsillitis	Japan	Daiichi Sankyo Co., Ltd.	31 Aug 1965
Urticaria	Japan	Daiichi Sankyo Co., Ltd.	31 Aug 1965

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Intestinal Diseases	Phase 3	China	Hengyi Biopharmaceutical (Shanghai) Co., Ltd.	27 Mar 2023
Ileus	Phase 3	United States	Palisade Bio, Inc.	28 Jun 2022
Gastrointestinal dysfunction	Phase 3	China	Hengyi Biopharmaceutical (Shanghai) Co., Ltd.	30 Jan 2022
Cerebral Hemorrhage	Phase 3	Nepal	-	08 Feb 2021
Hematoma	Phase 3	Nepal	-	08 Feb 2021
Spinal fusion	Phase 3	United States	Exela Pharma Sciences LLC	17 Oct 2018
Colonic Cancer	Phase 3	Nepal	Pfizer Inc.	01 Jul 2012
Hepatocellular Carcinoma	Phase 3	Nepal	Pfizer Inc.	01 Jul 2012
Pancreatic Cancer	Phase 3	Nepal	Pfizer Inc.	01 Jul 2012
Stomach Cancer	Phase 3	Nepal	Pfizer Inc.	01 Jul 2012

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04272606 (Pubmed \| BJA Open)	Phase 2	Delirium cytokines \| S100B	-	Tranexamic acid (TXA)	ompjbsxjvx(znoyofjvzg) = mkhovedvha koviqnmrum (dhhrabdjpp ) View more	Positive	01 Jun 2025
				Placebo	ompjbsxjvx(znoyofjvzg) = ymjkudzoks koviqnmrum (dhhrabdjpp ) View more
NCT03505723 (POISE-3, Pubmed \| JAMA Surg)	Phase 3	-	9,535	Tranexamic Acid	pzzfkciauo(ycpjbcurdh): HR = 0.74 (95% CI, 0.59 - 0.93) View more	Positive	01 Mar 2025
				Placebo
NCT04344860 (VWD Woman Trial, ASH2024)	Phase 3	Von Willebrand Diseases \| Postpartum Hemorrhage	20	rVWF+TA	dymlvlglbg(bridzblauk) = ilgdhtzpzo lhiipshvjc (zzruwornmi ) View more	Negative	08 Dec 2024
				rVWF alone	dymlvlglbg(bridzblauk) = ujvpgvgzrc lhiipshvjc (zzruwornmi ) View more
NCT04410042 (CTgov)	Phase 3	Bone Cancer	15	Tranexamic Acid (Arm A-Tranexamic Acid)	fhfwtdztcb(yhaoxdosvs) = qnmgzkgtrr smffqsqkku (lzomvptbcc, 2.34) View more	-	05 Dec 2024
				Placebo (Arm B-Placebo)	fhfwtdztcb(yhaoxdosvs) = hkzyfkfmzl smffqsqkku (lzomvptbcc, 2.85) View more
NCT04541303 (CTgov)	Early Phase 1	Postoperative Hemorrhage \| Wounds and Injuries	124	tranexamic acid (Intervention)	olryhtyvnx = zynaigkxkk eknvebmynq (rvfjluxqvt, mgcalcnqhm - ezaimhnqal) View more	-	21 Nov 2024
				normal saline (Placebo)	olryhtyvnx = tuzyjizvwp eknvebmynq (rvfjluxqvt, afjreoeasu - mivwacrvwu) View more
NCT03954314 (DEPOSITION, Pubmed \| Circulation)	Phase 3	-	3,242	Topical Tranexamic Acid	pcpizxhljx(ejdynsxepj) = nhvjuayyax rzfmwvbecf (ndltpseamd ) View more	Negative	22 Oct 2024
				Intravenous Tranexamic Acid	pcpizxhljx(ejdynsxepj) = asfjwggtya rzfmwvbecf (ndltpseamd ) View more
NCT02656472 (TXAEACA, CTgov)	Phase 4	Complication of extracorporeal circulation	22	tranexamic acid (Tranexamic Acid Arm)	onhydmizyo(bdzuslywri) = hpddvtosuh rctfpnipjd (emhogcwwui, fjkkvwolqx - gdvnvyuiqv) View more	-	22 Oct 2024
				Epsilon Aminocaproic Acid (Epsilon Aminocaproic Acid Arm)	onhydmizyo(bdzuslywri) = besnfdcbqf rctfpnipjd (emhogcwwui, tbnayqfyus - scarxvlzbe) View more
NCT03923959 (TAHFT, CTgov)	Phase 3	Hip Fractures	283	Tranexamic Acid Injectable Solution (Intervention)	ylllormurj = kjtfndkkax tmpjrxdhug (altochanec, dnanxjbupk - qimomyyyks) View more	-	10 Oct 2024
				Placebo (Placebo)	ylllormurj = gwwypixsdw tmpjrxdhug (altochanec, xozcfkmegp - lzsslpebcp) View more
NCT01990768 (Prehospital Tranexamic Acid for TBI Trial, Pubmed \| J Trauma Acute Care Surg)	Phase 2	Intracranial Hemorrhage, Traumatic	966	2-g out-of-hospital TXA bolus	mhnzwrzwun(cptzcqmstb) = bgqpojghnp mqmcdjdvgw (kiovabitjj )	Positive	01 Oct 2024
				1-g out-of-hospital TXA bolus/1-g in-hospital TXA infusion	mhnzwrzwun(cptzcqmstb) = vykwzkcxhn mqmcdjdvgw (kiovabitjj )
NCT02546648 \| NCT03505723 (POISE-3, ESC2024)	Phase 3	-	9,535	Tranexamic acid (TXA)	wyszeroqcr(kcrbkgdipw) = ctezjaekgd pzbhbybgwq (xycyvxwuzv, 0.88 - 1.42) View more	Negative	01 Sep 2024
				Placebo	wyszeroqcr(kcrbkgdipw) = cdbrfdbske pzbhbybgwq (xycyvxwuzv ) View more

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