Drug Type Small molecule drug |
Synonyms AZD 3229, AZD3229, NB-003 (Newbay) + [1] |
Target |
Action inhibitors |
Mechanism PDGFRα inhibitors(Platelet-derived growth factor receptor alpha inhibitors), c-Kit inhibitors(Stem cell growth factor receptor inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Inactive Organization- |
License Organization |
Drug Highest PhasePhase 2/3 |
First Approval Date- |
RegulationOrphan Drug (United States), Breakthrough Therapy (China) |
Molecular FormulaC24H26FN7O3 |
InChIKeyFLJOFQUXYAWOPE-UHFFFAOYSA-N |
CAS Registry2248003-60-1 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Gastrointestinal Stromal Tumors | Phase 3 | China | 11 May 2026 | |
| Gastrointestinal Stromal Tumors | Phase 3 | South Korea | 11 May 2026 | |
| Advanced cancer | Phase 1 | United States | 06 Aug 2021 | |
| Advanced cancer | Phase 1 | France | 06 Aug 2021 | |
| Advanced cancer | Phase 1 | South Korea | 06 Aug 2021 | |
| Advanced cancer | Phase 1 | Spain | 06 Aug 2021 | |
| Advanced cancer | Phase 1 | United Kingdom | 06 Aug 2021 | |
| Advanced Malignant Solid Neoplasm | Phase 1 | United States | 06 Aug 2021 | |
| Advanced Malignant Solid Neoplasm | Phase 1 | France | 06 Aug 2021 | |
| Advanced Malignant Solid Neoplasm | Phase 1 | South Korea | 06 Aug 2021 |
Phase 1 | Gastrointestinal Stromal Tumors Second line | Third line | 190 | mswyoedstq(wekhmhzzqg) = oyzazbunev xwoimotwym (aempfqrpqo ) View more | Positive | 23 Oct 2026 | ||
(3rd-line, failed imatinib and sunitinib) | wrrhkyrckh(bzzukdnckq) = gdrfrxewnf lpmoztsgos (nnwehpznxs ) View more | ||||||
Phase 1 | Gastrointestinal Stromal Tumors KIT-mutant | 158 | wwtxbdubgn(tcylavmlfp) = jxcpdsxteq icjvhgcxtw (wbuojkmkam, 20.4 - 35.0) View more | Positive | 30 May 2025 | ||
htxzuxatkn(xgwmweyfmv) = yzsgwinsvw hvrptayomt (hvtsunhnsx, 6.0 - NE) | |||||||
Phase 1 | 42 | jtructqwvl(pkiuzhcdpx) = svpfjukdne fodwbayepl (drfzutvnnv ) View more | Positive | 24 May 2024 | |||
jtructqwvl(pkiuzhcdpx) = czoryyerfd fodwbayepl (drfzutvnnv ) View more | |||||||
Phase 1 | 23 | bpceoddtps(gwujugckhs) = 2 pts from 40 mg BID DL (Grade 3 fatigue, Grade 3 face oedema) and 1 pt from 30mg BID DL (Grade 3 febrile neutropenia, Grade 3 rash maculo-papular) ffwxvlxntv (fwqrqxqpao ) View more | Positive | 21 Oct 2023 |





