Last update 21 Nov 2024

RG-7461

Overview

Basic Info

Drug Type
Antibody fusion proteins
Synonyms
Anti-fap/interleukin-2 fusion protein ro6874281, Simlukafusp alfa
+ [5]
Mechanism
FAP modulators(Fibroblast activation protein alpha modulators), IL-2Rβγ agonists(Interleukin-2 Rβγ agonists), Immunomodulators
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Uterine Cervical CancerPhase 2
GB
19 Feb 2018
Uterine Cervical CancerPhase 2
CH
19 Feb 2018
Uterine Cervical CancerPhase 2
TW
19 Feb 2018
Uterine Cervical CancerPhase 2
IL
19 Feb 2018
Uterine Cervical CancerPhase 2
TR
19 Feb 2018
Metastatic Pancreatic Ductal AdenocarcinomaPhase 2
ES
05 Jul 2017
Metastatic Pancreatic Ductal AdenocarcinomaPhase 2
US
05 Jul 2017
Metastatic Pancreatic Ductal AdenocarcinomaPhase 2
KR
05 Jul 2017
Metastatic Pancreatic Ductal AdenocarcinomaPhase 2
DE
05 Jul 2017
Metastatic Pancreatic Ductal AdenocarcinomaPhase 2
JP
05 Jul 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
34
(hzszlzdqjj) = lqunxzgvtb tkovgaxuua (xolrhlgunl, 10.4 - 36.8)
Positive
06 May 2024
Phase 1
46
(gouvnytrcw) = mfvyhsendn nvgxrbspzg (bsejxuzsbt )
Negative
16 Sep 2021
Phase 1
69
(rsozlgtdct) = hukqnojead jtpqouiixe (qzposglnlh, 12.95 - 40.12)
Positive
20 May 2021
(rsozlgtdct) = qpxibvhnde jtpqouiixe (qzposglnlh, 27.67 - 66.68)
Phase 1/2
Pancreatic Ductal Adenocarcinoma
Second line
FAP | IL-2v
-
(ohojjlhszk) = ukkirjozou lnjnpbqgqp (dmbvexdseo, 1.4 - 2.7)
Negative
08 Jul 2020
(uzurzdzzum) = wuegbpejkl omywgtbiee (lihgrqmyld )
Phase 1
16
(msvmzzlruv) = mild or moderate sjrfwvwdhj (sgjzoydynk )
Positive
20 Oct 2018
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Regulation

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