Last update 24 Sep 2024
Nesuparib
Last update 24 Sep 2024
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms JPI 547, JPI-547, NOV 1402 + [4] |
Target |
Mechanism PARP inhibitors(Poly (ADP-Ribose) polymerase inhibitors), TNKS1 inhibitors(tankyrase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
Structure
Molecular FormulaC23H24N6O |
InChIKeyGRPXLKXGJAGYSD-UHFFFAOYSA-N |
CAS Registry2055357-64-5 |
Related
5
Clinical Trials associated with NesuparibPhase 2 Study of First-line Carboplatin and Paclitaxel in Combination With Pembrolizumab, Followed by Maintenance Pembrolizumab With or Without Nesuparib, in Patients With Newly Diagnosed Advanced or Recurrent MMR-proficient (pMMR) Endometrial Cancer
Phase 2 study of first-line carboplatin and paclitaxel in combination with pembrolizumab, followed by maintenance pembrolizumab with or without Nesuparib, in patients with newly diagnosed advanced or recurrent MMR-proficient (pMMR) endometrial cancer
A Multicenter, Open-label, Single-arm, Phase 2 Study to Evaluate the Efficacy and Safety of JPI-547, a PARP/TNKS Dual Inhibitor in Platinum-resistant, Advanced/Relapsed Ovarian Cancer Subjects Previously Treated With a PARP Inhibitor
100 Clinical Results associated with Nesuparib
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100 Translational Medicine associated with Nesuparib
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100 Patents (Medical) associated with Nesuparib
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100 Deals associated with Nesuparib
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Recurrent Endometrial Cancer | Phase 2 | - | 01 Aug 2024 | |
| Platinum-Resistant Ovarian Carcinoma | Phase 2 | KR | 31 Aug 2022 | |
| Pancreatic Cancer | Phase 2 | KR | - | |
| Pancreatic Ductal Adenocarcinoma | Phase 1 | KR | 30 Mar 2022 | |
| Secondary malignant neoplasm of pancreas | Phase 1 | KR | 30 Mar 2022 | |
| Advanced Malignant Solid Neoplasm | Phase 1 | KR | 06 Dec 2017 | |
| Advanced Malignant Solid Neoplasm | Phase 1 | KR | 06 Dec 2017 | |
| Colorectal Cancer | Phase 1 | - | - | |
| Colorectal Cancer | Phase 1 | - | - |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
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NCT04335604 (ASCO2021) Manual  | Phase 1 | 62 | (dose escalation) | vzoyejqkaa(zcitwsouse) = egjtpmvmoo oqajjkcbhp (ltmqwzlubo ) View more | Positive | 20 May 2021 | |
(dose escalation) | dmxnmineul(jicyuaivmm) = ytkbvfmghn knrknohquw (tqftidsxqh ) View more |
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