Last update 14 Dec 2024

CCT-245737

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
PNT-737, SRA 737, SRA-737
+ [1]
Target
Mechanism
Chk1 inhibitors(Checkpoint kinase 1 inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC16H16F3N7O
InChIKeyYBYYWUUUGCNAHQ-LLVKDONJSA-N
CAS Registry1489389-18-5

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Solid tumorPhase 2
US
30 Jan 2022
Advanced cancerPhase 2
ES
01 Jul 2016
Advanced cancerPhase 2
GB
01 Jul 2016
Advanced Malignant Solid NeoplasmPhase 2
ES
01 Jul 2016
Advanced Malignant Solid NeoplasmPhase 2
GB
01 Jul 2016
Non-Hodgkin LymphomaPhase 2
GB
01 Jul 2016
genital cancerPhase 1
GB
30 Jan 2023
Prostatic CancerPreclinical
GB
01 Mar 2024
Breast CancerPreclinical
GB
30 Jan 2022
Colonic CancerPreclinical
GB
30 Jan 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
137
(dose escalation cohorts)
fyyyfkkvtu(xmptltxwsq) = 3550 ng∙h/mL at 150 mg SRA737 nbulfybjvb (xjpoiiiqnn )
Positive
01 Jun 2019
(expansion cohorts)
Phase 1/2
18
xfgtemrrhf(ywmxqruspc) = 1000 mg QD or 500 mg BID ezudroavut (nwxsskelrr )
Positive
01 Jun 2019
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Core Patent

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Approval

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Regulation

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