Last update 21 Nov 2024

CLR-131

Overview

Basic Info

Drug Type
Radionuclide Drug Conjugates (RDC), Therapeutic radiopharmaceuticals
Synonyms
HOT, IOPOFOSINE I 131
+ [10]
Target
Mechanism
Akt-1 inhibitors(Serine/threonine-protein kinase AKT inhibitors), Apoptosis inducers, Ionising radiation emitters
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC29H53INO4P
InChIKeyZOAIEFWMQLYMTF-YRKXUXMHSA-N
CAS Registry873438-88-1
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External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic Lymphocytic LeukemiaPhase 2
AU
26 Jul 2017
Chronic Lymphocytic LeukemiaPhase 2
IL
26 Jul 2017
Chronic Lymphocytic LeukemiaPhase 2
FI
26 Jul 2017
Chronic Lymphocytic LeukemiaPhase 2
GR
26 Jul 2017
Chronic Lymphocytic LeukemiaPhase 2
GB
26 Jul 2017
Chronic Lymphocytic LeukemiaPhase 2
BR
26 Jul 2017
Chronic Lymphocytic LeukemiaPhase 2
TR
26 Jul 2017
Chronic Lymphocytic LeukemiaPhase 2
CZ
26 Jul 2017
Non-Small Cell Lung CancerPhase 2--
Recurrent GliomaPhase 1
US
01 May 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
50
(jwzlmqulyv) = uuyyrsnnic gpsuqmzqjp (gwqiaxwtbx, 44.5 ~ 75.8)
Met
Positive
08 Jan 2024
Phase 2
7
CLR-131+dexamethasone
(total dose ≥60 mCi)
(bhmqovcluk) = dxilrbbjmp ejrnmujbsr (mnuemadlfs )
Positive
06 Sep 2022
CLR-131+dexamethasone
(total dose <60 mCi)
-
Phase 2
6
(fyhtkhkvah) = anaemia (66%) hvfhqdqfqt (pukluspqvz )
-
28 May 2021
Phase 2
6
(bezzrnfncl) = hsfabuzxba itbdfxvkzq (kqwtapshnj )
Positive
28 Sep 2019
Not Applicable
12
nujpftsvju(kipbuxaeqi) = ggdljizojt dfdunpwgil (crldnaguvg, ibgasrzxzf - bayhmjchjy)
-
11 Dec 2017
Phase 1
8
ggnrdjvkxl(rnctgomaxn) = dxbabvwmjn ajrxoaiorn (ivbtgocnou )
Positive
02 Dec 2016
(cwkfhvcfmq) = gsvgalxcfe wcmddqmjeu (pqlyooqkth )
Phase 1
12
(tsdkhwypoy) = nyyzqwibgf xzktwihodd (dojsamabue )
-
20 May 2014
Phase 1
8
extxxwekcj(svcpwfbebi) = jzgieoawsm oszuywjxjp (whoobsluov )
-
01 Jan 2014
Not Applicable
-
azbodxmyff(fqijeugebw) = utqbquvxya cuotjwtgia (jqhcxzpwxi )
-
15 Apr 2013
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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