Delving into the Latest Updates on Fibrin Sealant (Human)(Baxter) with Synapse

Overview

Basic Info

Drug Type

Non-recombinant coagulation factor

Synonyms

Artiss

Target-

Mechanism-

Therapeutic Areas

Other Diseases

Active Indication

Burns

Inactive Indication-

Originator Organization

Baxter Healthcare Corp.

Active Organization

Baxter Healthcare Corp.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

US (19 Mar 2008),

Burns

Regulation-

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Gene Sequence

Sequence Code 15023190L

Sequence Code 452991633γ

Sequence Code 157626H

Sequence Code 802074131β

Sequence Code 4698119α

BACKGROUNDTraditional fixation of autografts in the treatment of burns involves the use of sutures and staples. A novel fibrin sealant, Artiss, has been introduced as an alternate method of fixation and has shown promising safety and efficacy results in the adult population. Our study assessed the effectiveness of fibrin sealant to secure autologous split thickness skin grafts (ASTSG) in the pediatric burn population.METHODSWe performed a retrospective cohort study of pediatric patients under 18 years of age who received autografting for the treatment of burns at our institution between 2017 and 2023. We compared ASTSG secured with fibrin sealant to those managed traditionally with sutures or staples. Outcomes of interest include the need for return trips to the operating room (OR), time to wound healing, graft take, and total time in the operating room.RESULTS83 patients underwent a total of 142 individual ASTSGs for management of unique body area injuries. 66.3 % were male, median age was 79 months, and scald was the most common mechanism of injury (41.0 %). Forty-five (39.5 %) traditionally affixed ASTSG required at least one return to the OR while only one (3.6 %) ASTSG secured with fibrin sealant required an additional return to the OR (p < 0.001). Graft take was similar in both groups (92.9 % for fibrin sealant vs. 93.9 % for traditional methods, p = 1). Time to wound healing was also similar: 16 vs. 15 days for fibrin glue and traditional methods, respectively (p = 0.23).CONCLUSIONOutcomes from autograft fixation with fibrin sealant were comparable to those treated with traditional methods, with a reduction in the need for return trips to the operating room. These data suggest that fibrin sealant is a suitable alternative to traditional fixation methods in pediatric autografting.

01 May 2024·Head & Neck

Drainless, day‐case lateral neck dissection with Artiss™ fibrin sealant: A prospective cohort study

Article

Author: Tabaksert, Ayla ; Lester, Shane ; Walters, Holt ; James, Tobias ; Rusius, Christopher

AbstractObjectiveLateral neck dissection (LND) is performed for staging/treatment of head and neck lesions. This traditionally includes placement of a drain and inpatient admission. Drainless, day‐case head and neck surgery is attractive due to cost‐effectiveness and reduced length of stay, but evidence is lacking in LND. We aim to investigate Artiss™ as an alternative to drain placement, facilitating day‐case LND.MethodsA prospective review was conducted of patients who underwent LND in a UK hospital over a 22‐month period.ResultsThirty‐nine patients were identified (27 Artiss™ only; 12 Artiss™ with a drain). Eight Artiss™ only patients were day‐case. All drains were removed by post‐operative day 2. There was no statistically significant difference in the number of complications between the two groups.ConclusionThis observational study demonstrates that for selected patients, Artiss™ could facilitate drainless, day‐case LND. Further controlled studies with matched groups and larger numbers are required to validate this.

01 Aug 2021·Plastic SurgeryQ4 · MEDICINE

Fibrin Sealant Artiss Compared to Progressive Tension Sutures With Stratafix in the Management of Wound Drainage Following Post-Bariatric Body-Contouring Surgery

Q4 · MEDICINE

Article

Author: Schwarzenberger, Sarah ; Langer, Stefan ; Spindler, Nick ; Zeplin, Philip H.

Background: Post-bariatric body-contouring surgery is one of the most rapidly growing areas in plastic surgery. One of the most common complications following post-bariatric body-contouring surgery is seroma. There are a number of approaches to reducing wound drainage and seroma formation. A promising strategy to reduce these complications is to develop effective methods for reducing dead space between the tissue layers. Methods: We conducted a retrospective trial assessing the use of human fibrin sealant Artiss in comparison to progressive tension sutures (PTS) with Stratafix, a bidirectional barbed suture device in patients undergoing post-bariatric body-contouring surgery. Thirty-six patients for abdominoplasty or lower-body-lift were evaluated. Treatment patients underwent procedure with fibrin sealant applied to adapt the tissue layers. Control patients underwent an identical procedure but with PTS. Primary outcome measures included total wound drainage and time to drain removal. Results: The use of Artiss in abdominoplasty was associated with a mean drain volume that was significantly higher and more days that were needed to remove all drains compared to the PTS group. In body-lift, the mean drain volume and number of days needed to remove all drains tended to be higher when using Artiss compared to the PTS group. Conclusion: The use of Artiss in post-bariatric body-contouring surgery did not decrease the rate of seromas and the length of time required for post-surgical drains when compared to PTS.

100 Deals associated with Fibrin Sealant (Human)(Baxter)

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