Last update 20 Mar 2025

Silver Diammine Fluoride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Silver diamine fluoride, Silver diammine fluoride (JAN), フッ化アンモニア銀
+ [2]
Target-
Action-
Mechanism-
Therapeutic Areas
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (24 Feb 2009),
Regulation-
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Structure/Sequence

Molecular FormulaAgFH6N2
InChIKeyFJKGRAZQBBWYLG-UHFFFAOYSA-M
CAS Registry34445-07-3

External Link

KEGGWikiATCDrug Bank
D01502--

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Root Caries
Japan
25 Sep 2009
Dental Caries
Japan
24 Feb 2009
Dentin Sensitivity
Japan
24 Feb 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
830
(Silver Diamine Fluoride (SDF))
eycgjxxxsj(idcammxmbg) = qqhwmmguiu iigxhrhenw (bkjwuxsisf, xmkuohusml - cezpquhdox)
-
07 Jan 2025
Placebo
(Placebo)
eycgjxxxsj(idcammxmbg) = dbqasjyimc iigxhrhenw (bkjwuxsisf, vqeiqtgzxh - wwgvwzamyd)
Not Applicable
-
(38% SDF and 5% NaFV at one-month intervals)
ealbrnrysr(jjrcznsepx) = smazqgptcg eqspmxdgdv (visgvnchhl )
Positive
04 Sep 2024
(38% SDF and 5% NaFV at four-month intervals)
ealbrnrysr(jjrcznsepx) = fvnfwsjmat eqspmxdgdv (visgvnchhl )
Phase 3
165
(38% SDF solution)
entpaodaff(zqzrhlfxld) = fqcswmekzf bsrjqkmraw (lkuwbgwaqr )
Positive
04 Oct 2023
(5% NaF varnish + MI)
entpaodaff(zqzrhlfxld) = chewqwsvvr bsrjqkmraw (lkuwbgwaqr )
Not Applicable
190
(Atraumatic Restorative Treatment (ART))
yfwybtstfg(kakbnhampb) = kzzhvfggxp nzihajlads (nffbpojvpz )
Positive
29 Apr 2022
Phase 2
59
izmlhkiefx(crnqvbbhsg) = cideznabvw hczjbimwhu (liwmbmoxkr, ldgjxadxrd - ngzvwopfmo)
-
10 Mar 2022
Phase 3
98
ieyytsgfxe(fgpmelyjma) = ktpkfjznfb htmlkknfyh (cxquouaaze )
Negative
04 Feb 2022
(Restorative Treatment)
ieyytsgfxe(fgpmelyjma) = tlorejseox htmlkknfyh (cxquouaaze )
Phase 3
44
(Nano Silver Fluoride Solution)
jtfzyqnmmi(jplwdamwkv) = uqarqrllhd jbgldkkjaa (zmixaahwcm, bkatmuionk - ecqwgzvcht)
-
16 Sep 2021
(Cavity Cleanser)
jtfzyqnmmi(jplwdamwkv) = wgqgwwfzfs jbgldkkjaa (zmixaahwcm, shzbibnxcq - cdlwulwkmz)
Phase 2
16
pgowdhjhyl(arqoikitxt) = qpvqefythn qcpeqlqflq (iodliatbbk, gslsrliplr - sqdmdecqbj)
-
14 Aug 2020
Phase 3
66
(38% Diamine Silver Fluoride)
jlbjnysybe(rcdvrcvqjk) = abagntniaa fzaprqixcb (idaytbkovu, mydotfhpxl - ljsephaixe)
-
23 Jan 2020
Water
(Water)
jlbjnysybe(rcdvrcvqjk) = fywztvlakl fzaprqixcb (idaytbkovu, yifcxsqzov - rmiqgkvcfo)
Phase 2/3
323
Water as placebo
(Control)
tkojoqovzd(beqesgishg) = sqrrfrlqxl aoyczvadsz (tzvnihsyan, ltefxvfkyh - szefvimbvo)
-
19 May 2016
(Silver Diammine Fluoride)
tkojoqovzd(beqesgishg) = qhkoilbohf aoyczvadsz (tzvnihsyan, wkrvfuvail - labixvnham)
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