Drug Type Small molecule drug |
Synonyms OFC, Olanzapine/fluoxetine, Symbyax + [2] |
Mechanism D1 receptor antagonists(Dopamine D1 receptor antagonists), D2 receptor antagonists(Dopamine D2 receptor antagonists), SERT inhibitors(Serotonin transporter inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date US (24 Dec 2003), |
Regulation- |
Molecular FormulaC34H39ClF3N5OS |
InChIKeyNEXXMCBZLDDQNK-UHFFFAOYSA-N |
CAS Registry250603-12-4 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Fluoxetine Hydrochloride/Olanzapine | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Bipolar and Related Disorders | CN | 30 Jun 2023 | |
Bipolar I disorder | US | 19 Mar 2009 | |
Depressive Disorder, Treatment-Resistant | US | 19 Mar 2009 | |
Depressive Disorder | US | 24 Dec 2003 |
Phase 3 | 892 | Olanzapine+Fluoxetine (OFC (SPIV)) | zecgekkbdk(fvgevisnxe) = iuluzlphvx syrnqvvram (bmwucriqjs, qjtvbplqqn - dytrwdgztk) View more | - | 01 Apr 2014 | ||
Fluoxetine (Flu) (Flu (SPIV)) | zecgekkbdk(fvgevisnxe) = rwjkfcqtbf syrnqvvram (bmwucriqjs, yguytmbzvl - mthonytpqh) View more | ||||||
Phase 4 | 291 | (Olanzapine/Fluoxetine Combination) | pheezhmtrl(gcsshfkwcj) = lwfggzlqio ffpbvzqbmv (cslszetnez, eezdgqbnjc - feuztazeji) View more | - | 18 Feb 2013 | ||
Placebo (Placebo) | pheezhmtrl(gcsshfkwcj) = guvxziqybg ffpbvzqbmv (cslszetnez, ftirlbhnnd - cewlhfnupl) View more |