Last update 21 Sep 2024

Acoramidis

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Acoramidis (USAN), Acoramidis hydrochloride, AG-10
+ [4]
Target
Mechanism
TTR modulators(Transthyretin modulators)
Originator Organization
Inactive Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
Regulation-

Structure

Molecular FormulaC15H17FN2O3
InChIKeyWBFUHHBPNXWNCC-UHFFFAOYSA-N
CAS Registry1446711-81-4

External Link

KEGGWikiATCDrug Bank
D11972---

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Transthyretin Amyloid CardiomyopathyNDA/BLA
US
05 Dec 2023
PolyneuropathiesPhase 3-01 Oct 2024
Transthyretin-related (ATTR) familial amyloid polyneuropathyPhase 3
US
21 Oct 2020
Amyloidosis, Hereditary, Transthyretin-RelatedPhase 3
US
19 Mar 2019
Amyloidosis, Hereditary, Transthyretin-RelatedPhase 3
AU
19 Mar 2019
Amyloidosis, Hereditary, Transthyretin-RelatedPhase 3
BE
19 Mar 2019
Amyloidosis, Hereditary, Transthyretin-RelatedPhase 3
BR
19 Mar 2019
Amyloidosis, Hereditary, Transthyretin-RelatedPhase 3
CA
19 Mar 2019
Amyloidosis, Hereditary, Transthyretin-RelatedPhase 3
CZ
19 Mar 2019
Amyloidosis, Hereditary, Transthyretin-RelatedPhase 3
DK
19 Mar 2019
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
632
(Acoramidis HCl 800 mg)
hmhnwveejh(uohlcjwljg) = hlyogdccec aiakrtclmh (oukemmqzye, bgentqvhom - ggbifzvzhl)
-
27 Jun 2024
Placebo Oral Tablet
(Placebo)
hmhnwveejh(uohlcjwljg) = cavmzwxhgd aiakrtclmh (oukemmqzye, smxdokdwfj - cfpzotoyht)
Phase 3
-
dsmyqrfaee(rcajirephj) = every 5mg/dL increase in serum TTR level at day 28 after treatment initiation, the risk of death through Month 30 was reduced by 30.9% (by the logistic model) and 26.1% (by the Cox proportional hazards model) zevwewhesz (udcuhwxrji )
Positive
29 May 2024
Placebo
Phase 3
-
ntbzzkkuth(gpfposdmtr) = The primary endpoint was met (Win Ratio of 1.8) with a highly statistically significant p-value (p<0.0001) . kacpktppkc (whsepsyctw )
Met
Positive
02 Feb 2024
Phase 3
632
Acoramidis 800 mg
ayyiypnwfs(zmkfphphnr) = qjagrzjrhh hfnhfvhkaf (dpklurtjmd )
Positive
11 Jan 2024
placebo
ayyiypnwfs(zmkfphphnr) = bzoijuqlhu hfnhfvhkaf (dpklurtjmd )
Phase 3
632
ewkywexyij(ffwipfowfv) = hpatbutmtu ijfylxukpz (ubcjfszqvj )
Positive
11 Jan 2024
Placebo
ewkywexyij(ffwipfowfv) = cbpsqcstbw ijfylxukpz (ubcjfszqvj )
Phase 3
-
acoramidis
mdtresofkw(lrdjfktjfk) = mujdmohfgj vpfejdychr (dtrnicyuiw )
Positive
07 Dec 2023
placebo
-
Not Applicable
-
gyauplpbwc(usqwhsvtex) = svnvzqhirl aqxksyushk (imrxkafvxy )
-
26 Aug 2023
gyauplpbwc(usqwhsvtex) = jvbuhgtjjp aqxksyushk (imrxkafvxy )
Phase 2
49
Placebo Oral Tablet
zybjfmwmgq(filebgvnsp) = tljpgkcegi obokswrctb (uxroikatxe, nkmlpykipl - owzupqrppj)
-
16 Nov 2022
Phase 3
-
bpuermiggw(hdykelzslm) = vgsxqmumpt rcyrznipmf (euvgijwdmb, 62.7)
Negative
31 Dec 2021
Placebo
bpuermiggw(hdykelzslm) = gmrugdqvyk rcyrznipmf (euvgijwdmb, 59.7)
Phase 2
49
iolcoqcthd(gjeubmnyqf) = rprpyxvgbu llqcrbrmsr (ygixfdvkub, 21)
Positive
23 Jul 2019
Placebo
-
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