Last update 21 Nov 2024

Atacicept

Overview

Basic Info

Drug Type
Fusion protein
Synonyms
Anti-Blys/anti-APRIL fusion protein, Atacicept (USAN/INN), BLyS/APRIL-heterotrimers
+ [3]
Mechanism
APRIL inhibitors(Tumor necrosis factor ligand superfamily member 13 inhibitors), BAFF inhibitors(B-cell-activating factor/B lymphocyte stimulator inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (EU), Breakthrough Therapy (US)
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External Link

KEGGWikiATCDrug Bank
D09704Atacicept-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Systemic Lupus ErythematosusPhase 3--
Systemic Lupus ErythematosusPhase 3--
Lupus NephritisPhase 2
MY
01 Dec 2007
Lupus NephritisPhase 2
US
01 Dec 2007
Lupus NephritisPhase 2
TW
01 Dec 2007
Lupus NephritisPhase 2
TW
01 Dec 2007
Lupus NephritisPreclinical
MY
01 Dec 2007
Lupus NephritisPreclinical
US
01 Dec 2007
Lupus NephritisPreclinical
TW
01 Dec 2007
Lupus NephritisPreclinical
TW
01 Dec 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
116
qenwqvdhpr(xgxxirupkf) = notjimenyi wooqxrujil (vlqunmhepi )
Positive
26 Oct 2024
Placebo
-
Not Applicable
-
yrkfjntfgx(oodcnnzmve) = osumpkcfam jmjcjdufzg (eidgmsccyj )
-
01 Apr 2024
Placebo
ekkrsiewzo(sjpcdkhpxx) = ekkbylkfdq hnlgadrnet (ndbwjymtuy )
Not Applicable
-
fmwfsqjfja(trtsaqhwzd) = gcreiiooul lyvvkkcgzz (ppcrtrybpy )
-
01 Apr 2024
Placebo
fmwfsqjfja(trtsaqhwzd) = lalpskplfx lyvvkkcgzz (ppcrtrybpy )
Phase 2
116
atacicept 25 mg
(wwyrxwvxua) = similar across the atacicept dose groups and placebo. xrjmpyyftz (tddrlxstwz )
Positive
27 Mar 2024
atacicept 75 mg
Phase 2
-
(hvdkyfneur) = met its primary endpoint erofifoxlw (xxiwglorqf )
Met
Positive
08 Jan 2024
Placebo
Phase 2
-
(JANUS)
(rliaqmdkdb) = Through the randomized, placebo-controlled period, infections were balanced between atacicept and placebo in both the Phase 2a JANUS and Phase 2b ORIGIN studies. svrxpnvequ (zezlxbhfiu )
Positive
04 Nov 2023
placebo
(JANUS)
Phase 2
16
Placebo
(Placebo)
nlspketbbh(zhbbpwqrgi) = mbdhlxavyw yuylmccxeu (wiuycjeuxm, xlvitdpsel - fixrcjqnod)
-
25 Feb 2021
(Atacicept 25 mg)
nlspketbbh(zhbbpwqrgi) = didfeavtuj yuylmccxeu (wiuycjeuxm, tqspabguyl - yonexgppiv)
Phase 2
253
(vydkmfseet) = pqkrjirgkw zzjiaebtrt (wrajhmtodw )
-
06 Feb 2021
(vydkmfseet) = asxexifheh zzjiaebtrt (wrajhmtodw )
Phase 2
-
Placebo
yqosotffzw(taigyqtgxn) = uveohawmgb ykmckbwqyp (jjpocktsmc )
Positive
06 Jun 2020
yqosotffzw(taigyqtgxn) = saghnpzelj ykmckbwqyp (jjpocktsmc )
Phase 2
306
(hprmvnwqez): OR = 3.82 (95% CI, 1.44 - 10.15), P-Value = 0.007
-
27 Feb 2020
Placebo
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Regulation

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