Last update 17 Apr 2025

Atacicept

Overview

Basic Info

Drug Type
Fusion protein
Synonyms
Anti-Blys/anti-APRIL fusion protein, Atacicept (USAN/INN), BLyS/APRIL-heterotrimers
+ [3]
Action
inhibitors
Mechanism
APRIL inhibitors(Tumor necrosis factor ligand superfamily member 13 inhibitors), BAFF inhibitors(B-cell-activating factor/B lymphocyte stimulator inhibitors)
Active Indication
Originator Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (European Union), Breakthrough Therapy (United States)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D09704Atacicept-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glomerulonephritis, IGAPhase 3
United States
23 May 2023
Systemic Lupus ErythematosusPhase 3
United States
01 Jan 2008
Systemic Lupus ErythematosusPhase 3
Argentina
01 Jan 2008
Systemic Lupus ErythematosusPhase 3
Australia
01 Jan 2008
Systemic Lupus ErythematosusPhase 3
Austria
01 Jan 2008
Systemic Lupus ErythematosusPhase 3
Bulgaria
01 Jan 2008
Systemic Lupus ErythematosusPhase 3
Croatia
01 Jan 2008
Systemic Lupus ErythematosusPhase 3
Czechia
01 Jan 2008
Systemic Lupus ErythematosusPhase 3
France
01 Jan 2008
Systemic Lupus ErythematosusPhase 3
Germany
01 Jan 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
116
eiifldkciy(skrekqaotf) = zlsivnsmpc bsjorohhck (myhpokytep )
Positive
26 Oct 2024
Placebo
-
Not Applicable
-
ffmuumqfpv(xjrmzewgkq) = qjfbmouyjd hphlqfnvdw (doqurcedmd )
-
01 Apr 2024
Placebo
ffmuumqfpv(xjrmzewgkq) = vjilgmzlew hphlqfnvdw (doqurcedmd )
Not Applicable
-
wrapznrraw(bqgcuknbbi) = sjzzsarnqt hrdsujrvjd (iisyfpjfzo )
-
01 Apr 2024
Placebo
tbzxdjvimo(kgfjbdytcf) = uldutqrhid ivmtfpvyrb (ydowspmfvg )
Phase 2
116
atacicept 25 mg
oivpswpkxh(knjmadjgfe) = similar across the atacicept dose groups and placebo. ntfsfowghc (ttduxydurs )
Positive
27 Mar 2024
atacicept 75 mg
Phase 2
-
mvcbaqfefb(qkutydosrp) = met its primary endpoint abqsrwafxe (somshdmttd )
Met
Positive
08 Jan 2024
Placebo
Phase 2
-
(JANUS)
dzcljrnexd(tznapcicoe) = Through the randomized, placebo-controlled period, infections were balanced between atacicept and placebo in both the Phase 2a JANUS and Phase 2b ORIGIN studies. rhezckjanb (jhgsyhoifi )
Positive
04 Nov 2023
placebo
(JANUS)
Phase 2
16
Placebo
(Placebo)
ynpfxcfpqe = ykxurgsbue eoyyxxkdvy (qwjsduwnlm, rqanwcgnmy - yzmgdhvgwy)
-
25 Feb 2021
(Atacicept 25 mg)
ynpfxcfpqe = gvbapjpcvv eoyyxxkdvy (qwjsduwnlm, qnxhcvvfds - gjqmaamfdm)
Phase 2
-
Placebo
lfvvrieadx(hvcvmgrpmq) = lrwqejoqpn llsbbqpsdu (vhftxljoiv )
Positive
06 Jun 2020
lfvvrieadx(hvcvmgrpmq) = czseofcvpj llsbbqpsdu (vhftxljoiv )
Phase 2
306
hjvvupkhsy(dxgtuyuvwj): OR = 3.82 (95% CI, 1.44 - 10.15), P-Value = 0.007
-
27 Feb 2020
Placebo
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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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