Drug Type Small molecule drug |
Synonyms Donafenib, Donafenib tosilate, Zeprosen + [4] |
Target |
Action inhibitors, antagonists |
Mechanism CRAF inhibitors(C-Raf kinase inhibitors), PDGFR antagonists(Platelet-derived growth factor receptor antagonists), VEGFR antagonists(Vascular endothelial growth factor receptor antagonists) |
Therapeutic Areas |
Active Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date China (08 Jun 2021), |
RegulationPriority Review (China) |
Molecular FormulaC28H24ClF3N4O6S |
InChIKeyIVDHYUQIDRJSTI-NIIDSAIPSA-N |
CAS Registry1333386-17-6 |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Thyroid Cancer | China | 10 Aug 2022 | |
| Hepatocellular Carcinoma | China | 08 Jun 2021 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Refractory Differentiated Thyroid Gland Carcinoma | Phase 3 | China | 26 Jul 2018 | |
| Colorectal Cancer | Phase 3 | China | 23 Dec 2016 | |
| Metastatic Colorectal Carcinoma | Phase 3 | China | 23 Dec 2016 | |
| Advanced Hepatocellular Carcinoma | Phase 3 | China | 01 Mar 2016 | |
| Advanced Malignant Solid Neoplasm | Phase 2 | China | 10 May 2024 | |
| Intrahepatic Cholangiocarcinoma | Phase 2 | China | 19 Jan 2021 | |
| Advanced gastric carcinoma | Phase 2 | China | 11 Jan 2021 | |
| Bile Duct Neoplasms | Phase 2 | China | 11 Jan 2021 | |
| Nasopharyngeal Carcinoma | Phase 2 | China | 08 Feb 2017 | |
| Refractory Thyroid Gland Carcinoma | Phase 2 | China | 01 Sep 2016 |
Not Applicable | 40 | Donafenib + PD-(L)1 + TACE | ywoiytbovc(ganyslcfqa) = vjjlfbboac pegxaxvdae (gtxixypxss ) View more | Positive | 30 May 2025 | ||
Phase 2 | 30 | ericesqvrz(trgturqvfu) = ticextgrry goxcclqcxk (uiiexrptcd ) View more | Positive | 30 May 2025 | |||
Not Applicable | 199 | Donafenib monotherapy | ppkidruoas(byaodnxrzj) = 114 patients (57.3%) experienced treatment-related adverse events (TRAE) of any grade, with an incidence of grade 3 TRAE at 8.0% concluding with rash (5.5%), hand-foot syndrome (2.0%) and thrombocytopenia (0.5%); no patients experienced grade 4 or 5 TRAE roxgincxml (fmrrgtmmsa ) View more | Positive | 30 May 2025 | ||
Not Applicable | 76 | Donafenib + TACE + PD-1 inhibitors | urjncnznpn(pqgmedysny) = 65 patients (85.5%) maintained or improved ALBI grading at the end of treatment lexgmtbvpi (bffqnhgemr ) View more | Positive | 30 May 2025 | ||
Not Applicable | Hepatocellular Carcinoma Adjuvant preoperative AFP level | number of tumors | maximum diameter of tumors ... View more | 40 | cgzqylpwoc(nweyrchlkn) = iqhcmvfjgo vyrkbouetd (yhaebcysql ) View more | Positive | 30 May 2025 | ||
Not Applicable | Hepatocellular Carcinoma Adjuvant preoperative AFP level | number of tumors | maximum diameter of tumors ... View more | 44 | diytikfmor(wvqncdtmjh) = yptrvvqelm xpankpchsp (zsemtjtksi ) View more | Positive | 30 May 2025 | ||
Not Applicable | Unresectable Hepatocellular Carcinoma HBV infection | 64 | vqghkbzugl(vyebbyebbn) = fzynlmlctv gojfgsyvhp (knwluvtszl, 7.2 - 17.4) View more | Positive | 30 May 2025 | ||
Phase 2 | Neoplasms Adjuvant | 70 | cpefidyynl(zlmjdwjcbb) = iejfqchqci bhwkwebmob (rizkwlfmvu ) | Positive | 30 May 2025 | ||
cpefidyynl(zlmjdwjcbb) = cuwgdxasjs bhwkwebmob (rizkwlfmvu ) | |||||||
Not Applicable | Adjuvant AFP | 28 | Donafenib+PD-1 checkpoint inhibitor | sxucinieda(xaozybufww) = vyjsltvbnn luxcmqwghn (qfkhyjnzmr ) View more | Positive | 30 May 2025 | |
Not Applicable | 15 | oegbjcfimj(cvzcmsxsev) = hzyljfdlgt qdvemopnga (uifmjyowgb ) View more | Positive | 30 May 2025 |





