Case of the month from Lillebaelt hospital, University Hospital of South Denmark, Denmark: Renacidin^® – still a useful adjunct to endoscopic surgery for complex renal struvite stone disease

Article

Author: Jung, Helene ; Sloth Osther, Susanne ; Osther, Palle Jörn Sloth ; Øbro, Louise Faurholt

01 Jun 2016·UrolithiasisQ2 · MEDICINE

Irrigation with N,N-dichloro-2,2-dimethyltaurine (NVC-422) in a citrate buffer maintains urinary catheter patency in vitro and prevents encrustation by Proteus mirabilis

Q2 · MEDICINE

Article

Author: Debabov, Dmitri ; Najafi, Ron ; Rani, Suriani Abdul ; Celeri, Chris ; Bley, Keith

Long-term use of indwelling urinary catheters can lead to urinary tract infections and loss of catheter patency due to encrustation and blockage. Encrustation of urinary catheters is due to formation of crystalline biofilms by urease-producing microorganisms such as Proteus mirabilis. An in vitro catheter biofilm model (CBM) was used to evaluate current methods for maintaining urinary catheter patency. We compared antimicrobial-coated urinary Foley catheters, with both available catheter irrigation solutions and investigational solutions containing NVC-422 (N,N-dichloro-2,2-dimethyltaurine; a novel broad-spectrum antimicrobial). Inoculation of the CBM reactor with 10(8) colony-forming units of P. mirabilis resulted in crystalline biofilm formation in catheters by 48 h and blockage of catheters within 5 days. Silver hydrogel or nitrofurazone-coated catheters did not extend the duration of catheter patency. Catheters irrigated daily with commercially available solutions such as 0.25 % acetic acid and isotonic saline blocked at the same rate as untreated catheters. Daily irrigations of catheters with 0.2 % NVC-422 in 10 mM acetate-buffered saline pH 4 or Renacidin maintained catheter patency throughout 10-day studies, but P. mirabilis colonization of the CBM remained. In contrast, 0.2 % NVC-422 in citrate buffer (6.6 % citric acid at pH 3.8) resulted in an irrigation solution that not only maintained catheter patency for 10 days but also completely eradicated the P. mirabilis biofilm within one treatment day. These data suggest that an irrigation solution containing the rapidly bactericidal antimicrobial NVC-422 in combination with citric acid to permeabilize crystalline biofilm may significantly enhance catheter patency versus other approved irrigation solutions and antimicrobial-coated catheters.

01 May 2016·Seminars in DialysisQ3 · MEDICINE

An Unusual yet “Mg”nificent Indication for Hemodialysis

Q3 · MEDICINE

Article

Author: Bansal, Amar D. ; Warburton, Karen M. ; Negoianu, Dan

AbstractHypermagnesemia is an uncommon electrolyte abnormality, due to the fact that magnesium toxicity is only seen in the setting of a massive exposure to exogenous magnesium, often in the setting of renal insufficiency. Here, we report a case of severe hypermagnesemia that resulted in complete paralysis that was secondary to Renacidin administration, a rarely used agent used for intra‐renal pelvic or intra‐vesicular instillation dissolution of struvite stones. The patient also had concurrent acute kidney injury (AKI). The patient's magnesium was as high as 16.7 mg/dL, and he initially received hemodialysis followed by continuous venovenous hemodialysis. These therapies resulted in a rapid reduction in magnesium levels and eventual resolution of the muscular weakness. The case discussion highlights several key aspects of magnesium homeostasis, the limited mechanistic understanding of Renacidin‐induced hypermagnesemia, and the role of renal replacement therapies in the treatment of hypermagnesemia.

100 Deals associated with Citric Acid/Gluconolactone/Magnesium Carbonate

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Indication	Country/Location	Organization	Date
Urinary Bladder Calculi	US	United-Guardian, Inc.	02 Oct 1990

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


V05-04 (AUA2021)	Not Applicable	Calculi	-	Renacidin	(dfwdavxyat) = bednwggfuf cadxgivihs (hrormybijo ) View more	-	01 Sep 2021

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