Last update 12 Mar 2025

Lurbinectedin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lurbinectedin (USAN/INN), Lurbinectedina, Tryptamicidin
+ [8]
Target
Mechanism
DNA inhibitors(DNA inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (15 Jun 2020),
RegulationOrphan Drug (US), Priority Review (CN), Conditional marketing approval (CN), Orphan Drug (KR), Orphan Drug (AU), Overseas New Drugs Urgently Needed in Clinical Settings (CN), Emergency Use Authorization (CN), Orphan Drug (CH), Conditional marketing approval (IL), Accelerated Approval (US), Orphan Drug (EU)
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Structure/Sequence

Molecular FormulaC41H44N4O10S
InChIKeyYDDMIZRDDREKEP-HWTBNCOESA-N
CAS Registry497871-47-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Small Cell Lung Cancer
US
15 Jun 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
LeiomyosarcomaPhase 3
US
21 Sep 2023
LeiomyosarcomaPhase 3
AT
21 Sep 2023
LeiomyosarcomaPhase 3
BE
21 Sep 2023
LeiomyosarcomaPhase 3
FR
21 Sep 2023
LeiomyosarcomaPhase 3
DE
21 Sep 2023
LeiomyosarcomaPhase 3
IT
21 Sep 2023
LeiomyosarcomaPhase 3
ES
21 Sep 2023
LeiomyosarcomaPhase 3
CH
21 Sep 2023
LeiomyosarcomaPhase 3
GB
21 Sep 2023
Recurrent Lung Small Cell CarcinomaPhase 3
US
22 Jul 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
47
platinum+Lurbinectedin+sacituzumab govitecan
(Urothelial Cancer (UC) Cohort)
kbxgkvymgz(tmieejjkrp) = yioxiexxjj orpnyidgwl (fcwukioqpg, oqjmfatbfa - krmtzxlnuw)
-
28 Feb 2025
(Poorly Differentiated Neuroendocrine Carcinomas (PD-NEC) Cohort)
kbxgkvymgz(tmieejjkrp) = xmjjqjrvzt orpnyidgwl (fcwukioqpg, zjvwxirdok - xipawjbssf)
Phase 1/2
28
xmggmajljf(jrudngyopa) = ssphhctkqz evmwwtoqav (zipertsogc, 27.5 - 66.1)
Positive
10 Feb 2025
(Platinum-resistant)
xmggmajljf(jrudngyopa) = quyhhagzuk evmwwtoqav (zipertsogc, 12.8 - 64.9)
Not Applicable
Extensive stage Small Cell Lung Cancer
Last line | Third line | Second line
47
zecdyvsxjn(jvihvzckjq) = ufimjuosvk sumuehhcct (dyuxpiyhwq, 7.642 - 10.758)
Positive
07 Dec 2024
(second-line)
zecdyvsxjn(jvihvzckjq) = xodqobskzf sumuehhcct (dyuxpiyhwq, 6.945~11.455)
Phase 3
-
cvtjrahiea(ibkiqevhry) = statistically significant improvement kkrfegkzrn (klemwahqzd )
Positive
16 Oct 2024
Phase 1/2
6
biyyryyumv(lvynbxtrwg) = rjoflduxhs xbusxdfhup (lsncdfpabo )
Positive
14 Sep 2024
Phase 2
101
Lurbinectedin 2.0 mg/m2 + IIrinotecan75 mg/m2
khonxrbwbs(rkvsmhnujp) = xmkzpuhuye luixydzsqn (mgxgftakku, 9.1 - 14.1)
Positive
14 Sep 2024
Lurbinectedin 2.0 mg/m^2 + Irinotecan 75 mg/m^2
(CTFI 30-90 d)
khonxrbwbs(rkvsmhnujp) = pkhsqqexlc luixydzsqn (mgxgftakku, 3.7 - 13.6)
Not Applicable
92
Lurbinectedin monotherapy
oacwmavhxg(mrsfmmzooo) = rxitwucyuw efjyvobkob (grxdfpibuw )
Positive
08 Sep 2024
(second-line + CTFI <90)
oacwmavhxg(mrsfmmzooo) = dkrezdhlol efjyvobkob (grxdfpibuw )
WCLC2024
ManualManual
Not Applicable
81
Platinum rechallenge
oxxyihpbjb(ccesslrtrr) = zhpqiyqmfo lagniodfox (ifzrxeglls, 4.99 - 15.64)
Similar
08 Sep 2024
oxxyihpbjb(ccesslrtrr) = rxaaachdfp lagniodfox (ifzrxeglls, 2.62 - 7.40)
Not Applicable
-
crwwmaabdk(fezpvpkrbq) = qtzpuqpoop zkxwgivmhf (utyxpzykpc )
-
08 Sep 2024
Not Applicable
-
(High SLFN11 expression)
zzepnymgns(krneqocmgh) = bkjevmxryh qxgmxuobiw (gzkgtgvcfl )
-
07 Sep 2024
(Low SLFN11 expression)
zzepnymgns(krneqocmgh) = dyivavyihq qxgmxuobiw (gzkgtgvcfl )
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