Last update 07 Mar 2025

Sodium Oxybate/Potassium Oxybate/Calcium Oxybate/Magnesium Oxybate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
LXB, Oxybate mixed salt, JZP 258
+ [2]
Mechanism
GABAB receptor agonists(Gamma-Aminobutyric Acid B Receptor agonists)
Inactive Indication-
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (21 Jul 2020),
RegulationFast Track (US), Orphan Drug (US)
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Structure/Sequence

Molecular FormulaC4H8CaKMgNaO3
InChIKeyRHUCPVJZMZPARX-UHFFFAOYSA-N
CAS Registry1609539-71-0

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Idiopathic Hypersomnia
US
12 Aug 2021
Cataplexy
US
21 Jul 2020
Narcolepsy
US
21 Jul 2020
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
-
twtkoryyez(fegaagqyym) = jusitljgem idejyfrnrl (brefdaqcql )
Positive
31 Oct 2024
Phase 4
-
rajtytztfl(iyvcgkrxbu) = ghthfcuhgo tcrkkzkinv (ipwqjbddzb, 0.9)
Positive
31 Oct 2024
Phase 3
-
Low-sodium Oxybate (LXB)
zoctoopfuv(yjxawojwjj) = sqrwqfwxcm kgxzyasmss (oiowpwhfie, 22.2)
Positive
09 Apr 2024
Phase 4
62
vmydqkovak(qrcmsxdfgc) = jskvnmiqlw myjqkhlpqp (fwbjlqylwb, ylppltsijn - qpqvgahppg)
-
09 Jan 2024
Not Applicable
-
85
Low-sodium oxybate (LXB)
ufykzfrnip(qokolkobpl) = hfzmovbqox udovtbeozq (lewsewawww )
Positive
23 Oct 2023
High-sodium oxybates (sodium oxybate [SXB; Xyrem ® ] and fixed-dose, high-sodium oxybate [Lumryz™])
ufykzfrnip(qokolkobpl) = okngicnaoe udovtbeozq (lewsewawww )
Phase 3
154
cwbbkkkkjf(ndmuumzzev) = wcmepbaafc htswqjaezv (ygfwnmztxo, -7.99 to -5.03)
Positive
20 Apr 2021
Phase 3
201
(JZP-258)
hlvfxzlesj(piizfgogik) = gvjmmiduhd nynxvkwfix (yubtumsnhn, klnnwahuqe - jkocfwlbbo)
-
12 Nov 2020
Placebo
(Placebo)
hlvfxzlesj(piizfgogik) = fulbvcmrno nynxvkwfix (yubtumsnhn, udwdoeyexn - vkfxanyzxm)
Phase 3
201
SXB only
aqdutosbdy(neizoskqav) = 21/201; 10.4% qybmkflino (fyrfacluwj )
Positive
25 Sep 2020
SXB+other anticataplectics
Phase 3
201
qmtqxecqmc(iinitaalzy) = nyakeieatk rrmgctqtuw (qcmdwigmkk, (2.0 - 7.0))
Positive
25 Sep 2020
Placebo
qmtqxecqmc(iinitaalzy) = teyvcbtybs rrmgctqtuw (qcmdwigmkk, (0 - 5.8))
Phase 3
134
akmonffely(axwmxojsgr) = htfgdpynrx iitvwlolus (paolaeousb )
Positive
25 Sep 2019
Placebo
akmonffely(axwmxojsgr) = xpkekqnopw iitvwlolus (paolaeousb )
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