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Last update 10 May 2025
LAM-003
Last update 10 May 2025
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms LAM 003 |
Target |
Action inhibitors |
Mechanism HSP90B inhibitors(Heat shock protein HSP 90-beta inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
License Organization- |
Drug Highest PhasePendingPhase 1 |
First Approval Date- |
Regulation- |
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Related
1
Clinical Trials associated with LAM-003NCT03426605
A Phase 1 Dose-Escalation Study of LAM-003 in Patients With Acute Myeloid Leukemia
100 Clinical Results associated with LAM-003
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100 Translational Medicine associated with LAM-003
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100 Patents (Medical) associated with LAM-003
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1
Literatures (Medical) associated with LAM-00326 Nov 2019Blood advancesQ2 · MEDICINE
LAM-003, a new drug for treatment of tyrosine kinase inhibitor–resistant FLT3-ITD–positive AML
Q2 · MEDICINE
Article
Author: Halene, Stephanie ; Zhang, Xuan ; Landrette, Sean ; Grotzke, Jeff E. ; Rothberg, Jonathan ; Beckett, Paul ; Young, Peter R. ; Andreeff, Michael ; Hernandez, Marylens ; Xu, Tian ; Carter, Bing Z. ; Gayle, Sophia ; Lichenstein, Henri ; Beeharry, Neil
Key Points:
The heat shock protein 90 inhibitor LAM-003 displays potent in vitro and in vivo activity as a single agent and combined with venetoclax. LAM-003 retains antileukemic activity against AML cells rendered resistant to FLT3 kinase inhibitors by mutation or stromal signaling.
100 Deals associated with LAM-003
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Acute Myeloid Leukemia | Phase 1 | United States | 16 Jan 2018 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Phase 1 | 17 | (LAM-003 200 mg QD) | maufogbohp = evmaevcxmc rguojnanrr (hrdavaumzq, vftffgjeuq - tzbilpvmht) View more | - | 03 May 2024 | ||
(LAM-003 300 mg QD) | maufogbohp = evqzfuzovi rguojnanrr (hrdavaumzq, jznzfwxbpt - jdkqvabdgz) View more |
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