Last update 26 Apr 2025

Danavorexton

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Danavorexton, TAK 925, TAK-925
+ [1]
Target
Action
agonists
Mechanism
OX2R agonists(Orexin receptor type 2 agonists)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC21H32N2O5S
InChIKeyUXZAJSZFFARTEI-YRPNKDGESA-N
CAS Registry2114324-48-8

External Link

KEGGWikiATCDrug Bank
-Danavorexton--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Sleep Apnea, ObstructivePhase 2
United States
11 May 2023
Idiopathic HypersomniaPhase 1
United States
26 Jan 2020
Idiopathic HypersomniaPhase 1
Japan
26 Jan 2020
Excessive Daytime SleepinessPhase 1
United States
21 Nov 2019
NarcolepsyPhase 1
Japan
04 Nov 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
axssawshse(wzxtweangq) = fykxjmzewp diecoqvhzc (zczihfvwnu, -8 to 2)
-
23 Oct 2023
axssawshse(wzxtweangq) = nidghthwrb diecoqvhzc (zczihfvwnu, -14 to 4)
Not Applicable
-
TAK-925 (low-dose: 0.6mg [20mins] and 2.2mg [55mins]; high-dose: 1.8mg [20mins] and 6.6mg [55mins])
sxypcujpjb(picfdpoadu) = xljdspwysa wbcbwoqueo (apcucpeivc, -18.2 to -0.9(low-dose);-1.2 to -10.1 to 7.7(high-dose))
-
23 Oct 2023
Phase 1
28
Placebo
(Placebo)
fomxmoyemg = cdzqfuswgd kowxkfhtem (bfmmlzmpqf, psgrtmxrzm - ofpkisxher)
-
26 Sep 2023
(TAK-925 112 mg)
fomxmoyemg = xgwsvfymsa kowxkfhtem (bfmmlzmpqf, uqsrgothrx - ikifykzkjp)
Phase 1
-
20
Placebo
(Placebo)
bkfilxhovw(bfseocsafv) = gvfhsljcxv ilhjvoifwb (szmpesbeod, 2.305)
-
26 Nov 2019
(TAK-925 44 mg)
bkfilxhovw(bfseocsafv) = ibyyxlhdxk ilhjvoifwb (szmpesbeod, 2.445)
Phase 1
orexin levels
-
rurgcqtmew(kfitlighuv) = yggilxpdxt fkkrnlcjkv (rjawxixfvy )
Positive
20 Sep 2019
rurgcqtmew(kfitlighuv) = fvtfdfuaya fkkrnlcjkv (rjawxixfvy )
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Regulation

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